1 results match your criteria: "The Second Xiangya Hospital of Central South Unniversity[Affiliation]"
The role of disulfidptosis-associated LncRNA-LINC01137 in Osteosarcoma Biology and its regulatory effects on macrophage polarization.
Funct Integr Genomics
November 2024
Orthopaedic Department, The Second Xiangya Hospital of Central South Unniversity, Hunan Province, Changsha, China.
Article Synopsis
- The research focuses on the role of long non-coding RNA (lncRNA) LINC01137 in osteosarcoma (OS) and its effects on macrophage polarization and the tumor immune microenvironment (TME), aiming to find new biomarkers and treatment targets.
- By analyzing transcriptome data, the study identified LINC01137 as highly expressed in OS and linked to disulfidptosis, and demonstrated that knocking it down reduced cell proliferation, migration, and invasiveness while enhancing cell death.
- In vivo experiments confirmed that silencing LINC01137 significantly inhibited tumor growth, indicating its critical role in OS development and suggesting its potential as a prognostic marker and therapeutic target.