The functional polymorphisms linked with interleukin-1β gene expression are associated with bipolar disorder.

Background: Bipolar disorder (BD) is a severe psychiatric illness attributable to multifactorial risk components (e.g. environmental stimuli, neuroinflammation, etc.

Intelligence quotient level and treatment of obsessive-compulsive disorders: Meta-analyses.

Background: Obsessive-compulsive disorder (OCD) is a highly heterogeneous mental disorder that could affect mental capacity and requires different treatment methods. The purpose of this meta-analysis study was to evaluate the OCD subjects' intelligence quotient (IQ) and the effect of different treatments on OCD.

Methods: Through a systematic literature search up to December-2019, 108-studies were identified, with 8049-subjects with 6719-OCD subjects.

Further evidence of VRK2 rs2312147 associated with schizophrenia.

Objectives: Previous genome-wide association studies (GWAS) have reported that rs2312147 near the VRK2 gene was significantly associated with schizophrenia in populations of European descent, but negative results have also been observed.

Methods: To perform a systematic meta-analysis, we collected statistical data of rs2312147 from both GWAS and individual replication samples in European and Asian populations, which finally included up to 30,867 schizophrenia patients and 59,863 healthy controls.

Results: The VRK2 rs2312147 was genome-wide significantly associated with schizophrenia in combined populations (P = 1.

[Association of RELN SNP rs7341475 with schizophrenia in the Chinese population].

Schizophrenia is a common and complex psychiatric disorder. Significant evidence has suggested that genetic factors play pivotal roles in the etiology of schizophrenia. More than 100 schizophrenia candidate genes have been reported; however, many of them do not have satisfactory replications among different populations.