4 results match your criteria: "The Second People's Hospital of Hefei Hefei 230011[Affiliation]"
Down-regulation of FOS-like antigen 1 enhances drug sensitivity in breast cancer.
Int J Clin Exp Pathol
August 2020
Department of Pathology, The Second People's Hospital of Hefei Hefei 230011, Anhui, P. R. China.
Objective: Multidrug resistance (MDR) to chemotherapeutic drugs is an important reason for clinical chemotherapy failure. So far, the relationship between FOS-like antigen1 (FOSL1) and chemotherapy sensitivity of breast cancer remains unclear. This study investigates the relationship between FOSL1 and chemotherapy sensitivity of breast cancer and its molecular mechanism.
View Article and Find Full Text PDFMicroRNA-130a reduces drug resistance in breast cancer.
Int J Clin Exp Pathol
July 2019
Department of Pathology, The Second People's Hospital of Hefei Hefei 230011, Anhui, China.
Objective: Although the advent of chemotherapy has made some progress in the comprehensive treatment of breast cancer, drug resistance of tumor cells remains to be one of the main challenges for the treatment of breast cancers. Several microRNAs have been implicated in the resistant process, but the role of miR-130a in drug resistance in breast cancer remains unclear. The present study aims to investigate the role and mechanisms of miR-130a in drug resistance in breast cancer cells and tissues.
View Article and Find Full Text PDFWhole grain and cereal fiber intake and the risk of type 2 diabetes: a meta-analysis.
Int J Mol Epidemiol Genet
June 2019
Department Epidemiology and Biostatistics, School of Public Health, Wannan Medical College Wuhu 241002, Anhui, China.
Article Synopsis
- Cardiovascular diseases (CVDs) are a growing global concern, prompting investigations into the links between whole grain or cereal fiber intake and type 2 diabetes risk.
- A review of relevant literature from various databases revealed eight studies involving 14,728 cases of type 2 diabetes among 434,903 participants.
- The findings indicated an inverse relationship, showing that higher whole grain and cereal fiber intake is associated with a reduced risk of developing type 2 diabetes (overall relative risk of 0.68).
Cardiac myocyte-protective effect of microRNA-22 during ischemia and reperfusion through disrupting the caveolin-3/eNOS signaling.
Int J Clin Exp Pathol
April 2016
Deparment of Vasculocardiology, The Second People's Hospital of Hefei Hefei 230011, Anhui, China.
MicroRNA-22 (miR-22) was previously reported to elicit cardiac myocyte hypertrophy and had an anti-apoptotic effect on neurons. However, its effects on cardiac myocyte apoptosis and cardiac function during ischemia and reperfusion (I/R) are not clear. In the present study, we demonstrate that pre-administration of miR-22 mimic reduced I/R-induced cardiac dysfunction significantly in a rat model.
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