antibacterial effect of vancomycin hydrogel on methicillin-resistant Staphylococcus aureus.

Objective: To evaluate the antibacterial effect of vancomycin hydrogel on methicillin-resistant Staphylococcus aureus (MRSA).

Methods: We used polylactide glycolide-polyethylene glycol-polylactide glycolide (PLGA-PEG-PLGA) copolymer as a carrier of vancomycin to prepare vancomycin hydrogel. A vancomycin hydrogel group, a PLGA-PEG-PLGA copolymer group, a phosphate-buffered saline (PBS) negative control group and a vancomycin group were set for comparison.

Correlation analysis of miRNA-124, miRNA-210 with brain injury and inflammatory response in patients with craniocerebral injury.

Objective: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage.

Material And Methods: Clinical data of 105 patients with CI (case group) admitted to our hospital from January 2018 to January 2020 were retrospectively analyzed. The other 60 non-CI healthy patients underwent physical examination were selected as the healthy group.

Clinical effects of insulin glargine combined with repaglinide in the treatment of type 2 diabetes.

Objective: To analyze the clinical effects of insulin glargine combined with repaglinide on the treatment of type 2 diabetes (T2D).

Methods: One hundred and twelve T2D patients were divided into two groups based on the treatment strategy, the control group (N=56) receiving insulin glargine and the experimental group (N=56) receiving insulin glargine combined with repaglinide. Clinical effects were analyzed and compared between the two groups.

Comparison of clinical effects of general anesthesia and intraspinal anesthesia on total hip arthroplasty.

Objective: To evaluate the clinical effects of general anesthesia and intraspinal anesthesia on total hip arthroplasty.

Methods: A total of 110 patients who underwent unilateral total hip arthroplasty in our hospital were randomly divided into the observation group and the control group, with 55 patients in each group. The observation group was given intraspinal anesthesia, while the control group was given general anesthesia.

Diagnostic value of nuclear medicine imaging and ultrasonography in subacute thyroiditis.

Objective: To analyze and compare the diagnostic value of nuclear medicine and ultrasonography in subacute thyroiditis.

Methods: Sixty patients with subacute thyroiditis admitted to our hospital were included into the observation group, and 60 healthy controls who underwent physical examination in our hospital during the same period were enrolled into the control group. Examinations of nuclear medicine and ultrasonography were performed in the neck, and the results were compared between the two groups.

The changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and analysis of their correlation with inflammatory factors and prognosis.

Objective: To explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis.

Methods: A total of 122 subjects with coronary heart disease who underwent interventional therapy in our hospital from January 2017 to January 2019 were chosen as the observation group, and 122 healthy people during the same period were chosen as the control group. We retrospectively analyzed the levels of serum miR-221, miR-222, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6).

Analysis of effect of high-quality nursing on pain of emergency orthopedic trauma patients and related factors affecting postoperative pain.

Objective: The purpose of this study is to analyze the influencing factors of postoperative pain in patients presenting with emergency orthopedic trauma, and to determine the effect of high-quality nursing on pain.

Methods: In this prospective study, 78 emergency orthopedic trauma patients were randomized into the research group for high-quality nursing and the control group for routine emergency nursing. The two groups were compared with respect to pain degree, pain resolution time, related clinical indexes, pre- and post-treatment joint range of motion (ROM) and psychological state, as well as nursing satisfaction and complications.

An effect analysis of vestibular rehabilitation training in vertigo treatment.

Objective: This study aimed to explore the clinical safety and effectiveness of vestibular rehabilitation training in the treatment of vertigo.

Methods: Patients with vertigo were randomly divided into an experimental group (51 cases) or a control group (51 cases) and were treated for 4 weeks. The Berg balance scale scores (BBS), the vestibular symptom index (VSI) scores, the balance experiment scores, the UCIA vertigo scores, and the vertigo symptom changes before and after the treatment were recorded, and the treatment success was investigated.

Research and application of KABP nursing model in cardiac rehabilitation of patients with acute myocardial infarction after PCI.

Objective: To investigate the effect of a nursing protocol based on the KABP (Knowledge, Attitude, Belief and Practice) model in the cardiac rehabilitation (CR) of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).

Methods: In this prospective study, a total of 76 patients with AMI who underwent PCI were selected as the research objects. Through random number table, the participants were divided into 41 cases in the KABP group (cardiac rehabilitation nursing based on KABP model) and 35 cases in the control group (conventional rehabilitation nursing).

MicroRNA-497-5p attenuates IL-1β-induced cartilage matrix degradation in chondrocytes via Wnt/β-catenin signal pathway.

Osteoarthritis (OA) is a degenerative joint disease. Degradation of extracellular matrix (ECM) in chondrocytes is closely related to joint destruction in OA progression. MicroRNAs (miRNAs) have been reported to play important roles in progression of OA.