3,266 results match your criteria: "The Second Military Medical University.[Affiliation]"

Chinese guidelines for the diagnosis and treatment of rheumatoid arthritis: 2024 update.

Rheumatol Immunol Res

December 2024

Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Beijing, China.

Rheumatoid arthritis (RA) is an autoimmune disease with destructive arthritis as its main clinical manifestation, which is a major cause of disability. It is very important to formulate and update a guideline for the diagnosis and treatment of RA that adhere to international guideline development standards and can be applied to clinical practice in China. This guideline is endorsed and developed by the National Clinical Research Center for Dermatologic and Immunologic Diseases, collaborated with Rheumatologists Branch of Chinese Medical Doctor Association, Rheumatology Rehabilitation Branch of Chinese Association of Rehabilitation Medicine, Rheumatology Branch of Chinese Research Hospital Association, and Rheumatology Branch of Beijing Association of Holistic Integrative Medicine, based on grading of recommendations assessment, development and evaluation (GRADE) and reporting items for practice guidelines in healthcare (RIGHT).

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Background: Chronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGVHD after allogenic hematopoietic cell transplantation (HCT) has become a major challenge.

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Prediction of pulmonary embolism by an explainable machine learning approach in the real world.

Sci Rep

January 2025

Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, People's Republic of China.

In recent years, large amounts of researches showed that pulmonary embolism (PE) has become a common disease, and PE remains a clinical challenge because of its high mortality, high disability, high missed and high misdiagnosed rates. To address this, we employed an artificial intelligence-based machine learning algorithm (MLA) to construct a robust predictive model for PE. We retrospectively analyzed 1480 suspected PE patients hospitalized in West China Hospital of Sichuan University between May 2015 and April 2020.

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Context: AMD3100, a CXCR4 antagonist, has beneficial effects immaculate in the treatment of acute lung injury (ALI).

Objective: ALI is a severe inflammatory condition associated with poor prognosis and limited treatment options. AMD3100, has therapeutic effects that reduce ALI.

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Sintilimab Plus Lenvatinib with or Without Radiotherapy for Advanced Hepatocellular Carcinoma with Pulmonary Metastasis.

J Hepatocell Carcinoma

November 2024

Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, People's Republic of China.

Background: Hepatocellular carcinoma (HCC) with pulmonary metastasis (PM) significantly worsens prognosis, and current treatment options remain limited.

Methods: A retrospective study was conducted on HCC patients treated with sintilimab combined with lenvatinib at three hospitals in China between 2020 and 2021. Progression-free survival (PFS), overall survival (OS), and tumor response based on RECIST 1.

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Article Synopsis
  • Increased levels of ROCK1 in the brains of Alzheimer's disease (AD) patients correlate positively with lysosomal dysfunction and Aβ accumulation, suggesting its role in AD pathogenesis.
  • The study demonstrates that knocking down ROCK1 enhances lysosomal function and promotes the clearance of Aβ by facilitating TFEB's nuclear distribution.
  • Targeting ROCK1 may provide a potential therapeutic strategy to restore lysosomal homeostasis and mitigate cognitive decline in AD models.*
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  • - NOX2 is an important molecule found mainly in neutrophils, and its deficiency is linked to several immune disorders like lupus, chronic granulomatous disease, and rheumatoid arthritis.
  • - The study investigated how NOX2 affects the process of neutrophil apoptosis and found that its deficiency leads to a type of cell death called pyroptosis.
  • - The findings suggest that lacking NOX2 increases certain reactive oxygen species and leads to the activation of specific proteins, revealing NOX2's crucial role in regulating neutrophil death and its potential implications in autoimmunity.
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  • - This study investigated the impact of phosphoglucomutase-1 (PGM1) expression on prognosis in hepatocellular carcinoma (HCC) patients, using immunohistochemistry to assess PGM1 levels in tumor tissues.
  • - Findings revealed that low levels of nuclear PGM1 in HCC tissues were linked to poor patient outcomes and that it served as an independent prognostic factor alongside other risk indicators like serum α-fetoprotein and TNM staging.
  • - The research concluded that combining nuclear PGM1 expression with other independent factors improved prognostic predictions, highlighting its potential as a useful biomarker for HCC patient prognosis.
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Characteristics and patient-reported outcomes of long-term cancer survivors after apatinib-based therapy: an online survey.

BMC Cancer

August 2024

Department of Oncology, Peking University International Hospital, 1 Life Park Road, Life Science Park of Zhongguancun, Changping District, Beijing, 102206, China.

Article Synopsis
  • * 436 patients who had been on apatinib for at least 5 years completed an online survey, revealing high satisfaction rates—over 96% were pleased with the drug's efficacy and safety.
  • * Most participants reported minimal issues with depression (97.0%) and insomnia (97.9%), and the treatment had a negligible negative effect on their daily lives, despite some common side effects like hand-foot syndrome and hypertension.
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Exploring the anti-ovarian aging mechanism of He's Yangchao formula: Insights from multi-omics analysis in naturally aged mice.

Phytomedicine

November 2024

Department of TCM Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310000, PR China; Research Institute of Women's Reproductive Health, Zhejiang Chinese Medical University, Hangzhou 310053, PR China; Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Hangzhou 310016, PR China. Electronic address:

Article Synopsis
  • - The study investigates the effects of He's Yangchao formula (HSYC), a compound made of eight herbs, on enhancing ovarian function and combating female reproductive aging, a growing public health concern.
  • - Researchers conducted experiments on naturally aged mice, assessing ovarian aging through various biological techniques and analyzing gut microbiota, metabolome, and transcriptome to uncover HSYC's mechanisms.
  • - Results showed HSYC improved follicular development and mitigated age-related dysfunctions by enhancing glutathione metabolism, which is crucial for countering ovarian aging, and enriching beneficial gut bacteria.
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  • * Tyrosine kinase inhibitors (TKIs) are a key treatment for advanced RCC, but some patients develop resistance, prompting research into combining TKIs with targeted metabolic therapies.
  • * The study identified DEPDC1 as a significant factor in promoting RCC progression and resistance, suggesting it could be a new target for improved treatment strategies in resistant cases.
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  • Long-term muscle atrophy and fibrosis from denervation hinder proper muscle recovery, with the TGF-β1-Smad signaling pathway playing a key role in these processes.
  • Research focused on microRNAs, particularly miR-21, reveals its increased expression during muscle atrophy and its involvement in inflammation and fibrosis responses.
  • Inhibiting miR-21 led to reduced muscle fibrosis and atrophy, indicating its role in regulating muscle degeneration, thus suggesting potential therapeutic strategies for muscle recovery.
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Assessment of Global and Regional Lung Compliance in Pulmonary Fibrosis With Hyperpolarized Gas MRI.

J Magn Reson Imaging

June 2024

Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.

Article Synopsis
  • Hyperpolarized Xe gas MRI can assess lung compliance both globally and regionally, providing insights into pulmonary fibrosis development in a rat model.
  • This study involved 20 Sprague-Dawley male rats, with 10 having induced fibrosis and 10 serving as controls, to evaluate the effectiveness of the MRI technique.
  • Results indicated significant differences in lung compliance between the groups, and the measurements correlated well with traditional pulmonary function tests, validating the MRI method for studying lung conditions.
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  • This study investigates tertiary lymphoid structures (TLSs) and tumor-infiltrating lymphocytes (TILs) in clear cell renal cell carcinoma (ccRCC), highlighting their roles in the tumor microenvironment.
  • The analysis of 754 ccRCC patients revealed that the presence of mature TLSs is linked to better overall survival, while a high number of scattered TILs is associated with poor prognosis.
  • Findings indicate that abundant and mature TLSs correlate with improved therapy response and decreased risk of relapse, underlining the complex relationship between immune structures and cancer progression.
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The combination of endoscopic ultrasound with endoscopic treatment of type 1 gastric variceal hemorrhage may improve the robustness and generalizability of the findings in future studies. Moreover, the esophageal varices should also be included in the evaluation of treatment efficacy in subsequent studies to reach a more convincing conclusion.

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The TRIM28/miR133a/CD47 axis acts as a potential therapeutic target in pancreatic necrosis by impairing efferocytosis.

Mol Ther

September 2024

Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225000, China. Electronic address:

Article Synopsis
  • - Efferocytosis is an important process where macrophages clear dying cells, helping to control inflammation and prevent further cell death, but its role in acute pancreatitis (AP) is not well understood.
  • - The study found that injured pancreatic tissues from humans and mice showed increased levels of CD47, a molecule that signals cells not to be eaten, and identified its regulation by the transcription factor TRIM28 and the microRNA miR-133a.
  • - Using gene editing and other techniques, the research demonstrated that CD47's role in efferocytosis is key to preventing pancreatic cell death in AP, suggesting that targeting the TRIM28-miR133a-CD47 pathway might be a promising treatment strategy. *
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Article Synopsis
  • * A 56-year-old man initially diagnosed with MLPS in his left calf developed a painless mass in his left parotid gland two months post-surgery, leading to a misdiagnosis of pleomorphic adenoma.
  • * The mass was ultimately confirmed as a metastasis of MLPS through advanced testing methods, highlighting the complexities and challenges in diagnosing this rare lesion.
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Article Synopsis
  • * Results showed that 90% of the patients had disease control, with a median overall survival of 14 months and a median progression-free survival of 9 months.
  • * Most patients experienced adverse events (AEs) related to the treatment, primarily from targeted therapy, but severe AEs (grade 4 or 5) were not reported, indicating low incidence of serious side effects.
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Assessment of pulmonary physiological changes caused by aging, cigarette smoking, and COPD with hyperpolarized Xe magnetic resonance.

Eur Radiol

November 2024

Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430071, China.

Article Synopsis
  • The study investigates how aging, cigarette smoking, and chronic obstructive pulmonary disease (COPD) affect lung function using xenon magnetic resonance (Xe MR) imaging.
  • It involved 90 participants divided into four groups: healthy young, age-matched controls, asymptomatic smokers, and COPD patients, measuring various lung parameters.
  • Results showed significant differences in lung function metrics across groups, highlighting that both smoking and COPD lead to worsening lung conditions, emphasizing the need for advanced imaging techniques for better patient understanding.
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  • - The study investigated the effectiveness of dexmedetomidine (DEX) in reducing postoperative delirium (POD) and inflammatory markers among elderly patients after thoracolumbar surgery, comparing it to a normal saline control in a randomized trial.
  • - Results showed that DEX lowered the incidence of POD to 18.2% versus 30.6% in the control group and reduced the levels of pro-inflammatory cytokines IL-6 and TNF-α by postoperative day 3, indicating a beneficial effect on inflammation.
  • - The research concluded that DEX is a safe and effective option for managing early POD and postoperative inflammatory responses in elderly patients, with no significant adverse effects reported between the treatment and control groups.
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Function and regulation of Rab GTPases in cancers.

Cell Biol Toxicol

May 2024

National Clinical Research Center for Child Health of the Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.

Article Synopsis
  • Rab small GTPases are crucial for regulating various cellular transport pathways and act as connectors between signaling and membrane trafficking by recruiting diverse effectors.
  • In cancer, Rab proteins can have dual roles, either promoting tumor growth as onco-proteins or inhibiting it as tumor suppressors, depending on specific contexts.
  • Research suggests that targeting Rab GTPases to correct disrupted vesicle transport may be a promising strategy to slow cancer progression, and these proteins could also serve as potential prognostic indicators in different types of cancer.
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Simple, ultrasensitive detection of superoxide anion radical mutations in melanoma mice with SERS microneedles.

Spectrochim Acta A Mol Biomol Spectrosc

August 2024

Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

Elevated levels of superoxide anion radicals (O) have been implicated in the pathogenesis of a variety of diseases, such as cancer, inflammatory diseases and autoimmune diseases. To determine the O concentration for assisting disease detection, a method based on surface-enhanced Raman scattering (SERS) combined with transparent polymer microneedles has been developed. Photocrosslinked NOA61 is used to prepare microneedles with sulfhydryl group, which can contribute to anchor gold nanoparticles (Au NPs) functionalized by p-mercaptobenzoic acid (PATP).

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