8 results match your criteria: "The Second Military Medical University of China[Affiliation]"
Sleep quality and gestational diabetes in pregnant women: a systematic review and meta-analysis.
Sleep Med
March 2020
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Poor sleep quality is very common among pregnant women. Gestational diabetes mellitus (GDM) has been related to various adverse maternal and neonatal outcomes. The aim of this systematic review was to examine the association between poor sleep quality and gestational diabetes risk.
View Article and Find Full Text PDFAbsence of VEGFR-1/Flt-1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model.
J Cell Physiol
June 2020
Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois.
Although degenerative disc disease (DDD) and related low back pain (LBP) are growing public health problems, the underlying disease mechanisms remain unclear. An increase in the vascular endothelial growth factor (VEGF) levels in DDD has been reported. This study aimed to examine the role of VEGF receptors (VEGFRs) in DDD, using a mouse model of DDD.
View Article and Find Full Text PDFIntra-individual variability in sleep is related to glycaemic control in adults with type 2 diabetes.
J Adv Nurs
April 2020
College of Nursing, The University of Illinois at Chicago, Chicago, IL, USA.
Article Synopsis
- The study aimed to explore differences in sleep patterns between weekdays and weekends in patients with type 2 diabetes, and how these patterns relate to glycaemic control.
- Results indicated that there were no significant differences in overall sleep parameters between the two timeframes, although participants slept slightly longer and went to bed later on weekends.
- It was found that greater variability in sleep duration and timing was associated with higher levels of haemoglobin A1C, suggesting the importance of stable sleep habits for managing diabetes.
Metformin promotes differentiation of human bone marrow derived mesenchymal stem cells into osteoblast via GSK3β inhibition.
Eur Rev Med Pharmacol Sci
November 2018
Department of Orthopedics, ChangZheng hospital, The Second Military Medical University of China, Shanghai, China.
Article Synopsis
- Metformin, a common diabetes medication, may promote bone formation by affecting mesenchymal stem cells (MSCs), although the exact mechanisms were not fully understood.
- The study measured key osteoblast markers and proteins in MSCs treated with metformin, revealing that metformin significantly enhances osteogenic differentiation and involves the GSK3β and Wnt signaling pathways.
- Inhibiting GSK3β phosphorylation blocked the osteogenic effects of metformin, indicating that metformin promotes MSC differentiation into osteoblasts by inhibiting GSK3β and that AMPK is crucial in this process.
Effect of continuous positive airway pressure on glucose metabolism in adults with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
Sleep Breath
May 2018
Department of Orthopedics, Changzheng Hospital, The Second Military Medical University of China, Shanghai, China.
Article Synopsis
- Obstructive sleep apnea (OSA) may worsen type 2 diabetes, prompting a review of the effects of continuous positive airway pressure (CPAP) on glucose metabolism.
- A systematic search of multiple databases identified six studies with 496 participants to evaluate the impact of CPAP on glucose metrics, showing no significant changes in A1C, fasting insulin, or glucose levels.
- While CPAP effectively reduces daytime sleepiness, the analysis indicates it does not improve glucose metabolism in individuals with type 2 diabetes and OSA, highlighting the need for larger studies with better compliance.
MiR-101 Targets the EZH2/Wnt/β-Catenin the Pathway to Promote the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.
Sci Rep
November 2016
Departmentof Orthopaedics, Changzheng Hospital, The Second Military Medical University of China, 415 Fengyang Road, Shanghai 200003, P.R. China.
Article Synopsis
- miRNA-101 (miR-101) plays a crucial role in the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) by promoting this process when overexpressed and suppressing it when depleted.
- The expression of miR-101 increases during osteogenic differentiation, and it targets enhancer of zeste homolog 2 (EZH2), whose activity can reverse the effects of miR-101 on osteogenic differentiation.
- Additionally, miR-101 enhances the expression of Wnt genes and activates the Wnt/β-catenin signaling pathway, contributing to in vivo bone formation by hBMSCs.
Glucocorticoid inhibits cell proliferation in differentiating osteoblasts by microRNA-199a targeting of WNT signaling.
J Mol Endocrinol
June 2015
Shanghai Key Laboratory for Bone and Joint DiseasesShanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No.197, The Second Ruijin Road, Luwan District, Shanghai 200025, People's Republic of ChinaDepartment of OrthopedicsChangzheng Hospital, The Second Military Medical University of China, Shanghai, People's Republic of China.
Article Synopsis
- Glucocorticoids (GCs) inhibit the proliferation of osteoblasts, contributing to GC-induced osteoporosis, and the mechanisms behind this are not fully understood.
- Recent studies suggest that microRNAs, particularly microRNA-199a-5p, play
Timing of surgical decompression for traumatic cervical spinal cord injury.
Int Orthop
December 2015
Department of Orthopaedics, Changzheng Hospital, The Second Military Medical University of China, 415 Fengyang Road, Shanghai, 200003, Peoples' Republic of China.
Purpose: Although there have been numerous studies aimed at determining the effects and safety of early vs. late surgical decompression for traumatic cervical spinal cord injury, controversies still exist regarding the optimal timing of surgery for this serious spinal trauma. This study was conducted to evaluate the effectiveness and safety of early vs.
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