4 results match your criteria: "The Second Hospital of Nanjing affiliated to Medical School of Southeast University[Affiliation]"
Enhanced radiation effect on SMCC7721 cells through endoplasmic reticulum stress induced by C225-GNPs and .
Oncol Lett
April 2018
Department of Oncology, The Second Hospital of Nanjing Affiliated to Medical School of Southeast University, Nanjing, Jiangsu 210003, P.R. China.
The high atomic number of gold nanoparticles (GNPs) enables them to offer potential as practical and efficient radiosensitizing agents for cancer radiotherapy applications. In the present study, it was demonstrated that GNPs can significantly modulate the irradiation response of hepatocellular carcinoma (HCC) cells and , of which the underlying mechanisms were investigated. Cetuximab (C225) is a targeting agent, which binds to the extracellular domain of epidermal growth factor receptor (EGFR).
View Article and Find Full Text PDFBackground: HIV-infected homosexual men are more frequently diagnosed with Kaposi's sarcoma. With the increase of HIV-infected homosexual men in China, we urgently need to know the KS-related human herpesvirus (KSHV/HHV-8) seroprevalence in this population. To investigate HHV-8 prevalence among HIV-positive homosexual men, we recruited 183 patients naive of antiretroviral therapy (ART) whose blood samples presented with HIV-antibody positive as confirmed by western blot.
View Article and Find Full Text PDFTelomerase antagonist imetelstat increases radiation sensitivity in esophageal squamous cell carcinoma.
Oncotarget
February 2017
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China.
Article Synopsis
- Esophageal cancer has high morbidity and mortality rates globally, and improving radiation therapy effectiveness by finding low-toxicity sensitizers is crucial.
- The study found that imetelstat, a telomerase inhibitor, enhances the sensitivity of esophageal cancer cells to radiation, leading to increased DNA damage and cell death (apoptosis).
- In vivo experiments showed that imetelstat not only promotes cell apoptosis but also inhibits cell proliferation, indicating its potential as a novel therapeutic strategy for treating esophageal squamous cell carcinoma.
Profile of HBV polymerase gene mutations during entecavir treatment in patients with chronic hepatitis B.
Clin Res Hepatol Gastroenterol
November 2016
The Second Hospital of Nanjing affiliated to Medical School of Southeast University, 210003 Nanjing, China. Electronic address:
Background/aims: We investigated the efficacy of entecavir (ETV) monotherapy in 54 naïve patients and 27 lamivudine (LMV) and/or adefovir (ADV) experienced patients.
Methods: Eighty-one chronic hepatitis B patients with a viral load above 4 log 10 copies/ml and high levels of serum alanine aminotransferase were treated with ETV 0.5mg daily.