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Objective: To compare the expression of nitricoxide synthase (NOS) in the osteogenesis tissues of gradual distraction and split osteotomy, and investigate molecular biology mechanism.

Methods: Thirty-six rabbits were randomly divided into gradual distraction group, high split osteotomy group and control group. A batch of 4 animals in each of the first 2 groups were sacrificed respectively on the 1st day, 1st, 2nd and 4th weeks after operation.

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