2 results match your criteria: "The Second Hospital Affiliated to The Second Military Medical University[Affiliation]"
Myelodysplastic syndrome associated with clopidogrel: a case report.
Int J Clin Pharmacol Ther
January 2012
Department of Cardiology, the Second Hospital Affiliated to the Second Military Medical University, Shanghai, China.
More than 3 million patients around the world have received clopidogrel, an inhibitor of platelet aggregation, which has largely replaced ticlopidine in clinical practice as it was believed to be devoid of the side effects caused by ticlopidine. We herein report the case of a woman who developed myelodysplastic syndrome (MDS) after 1 year of treatment with clopidogrel. The absence of other plausible causes suggests that her MDS was induced by clopidogrel.
View Article and Find Full Text PDFBortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6.
Leuk Res
January 2009
Department of Hematology, Changzheng Hospital, The Second Hospital Affiliated to The Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
Article Synopsis
- Multiple myeloma (MM) leads to increased activity of osteoclasts, resulting in bone damage and lytic lesions.
- The study found that the drug bortezomib inhibited osteoclast maturation and function in cells from MM patients, reducing the formation and activity of osteoclasts.
- Bortezomib's mechanism was linked to lower levels of TRAF6 production, indicating its potential as a treatment option for bone-related issues in myeloma.