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Objective: This study is aimed at determining the expression and function of the GASL1 and PI3K/AKT pathways in isoproterenol- (ISO-) induced heart failure (HF). To determine the moderating effect of valsartan (VAL) on the progression of ISO-induced HF and to elucidate the related mechanism.

Materials And Methods: First, in experiment, we examined the effect of VAL on cardiac function in rats with ISO-induced HF.

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