3 results match your criteria: "The Second Clinical Medical College of Wenzhou Medical College[Affiliation]"

The adverse effect of selective cyclooxygenase-2 inhibitor on random skin flap survival in rats.

PLoS One

July 2014

Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical College, The Second Clinical Medical College of Wenzhou Medical College, Wenzhou, China.

Background: Cyclooxygenase-2(COX-2) inhibitors provide desired analgesic effects after injury or surgery, but evidences suggested they also attenuate wound healing. The study is to investigate the effect of COX-2 inhibitor on random skin flap survival.

Methods: The McFarlane flap model was established in 40 rats and evaluated within two groups, each group gave the same volume of Parecoxib and saline injection for 7 days.

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Article Synopsis
  • The study aimed to investigate the protective effects of Qingxin Kaiqiao Fang on PC12 cell injury caused by sodium dithionite (Na2S2O4), contributing to its potential clinical applications.
  • SD rats were given a specific dose of Qingxin Kaiqiao Fang to prepare cerebrospinal fluid, which was then tested on PC12 cells exposed to Na2S2O4, comparing cell activity and relevant mRNA expressions to a control group.
  • Results revealed that cerebrospinal fluid containing Qingxin Kaiqiao Fang significantly improved PC12 cell activity and altered the expression of apoptosis-related mRNA, indicating its protective benefits against neurocyte injury.
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Effects of vinpocetine on random skin flap survival in rats.

J Reconstr Microsurg

July 2013

Department of Plastic and Hand Surgery, The 2nd Affiliated Hospital of Wenzhou Medical College, The Second Clinical Medical College of Wenzhou Medical College, Wenzhou, China.

The effect of vinpocetine on flap survival, vascular endothelial growth factor (VEGF) expression, and superoxide dismutase (SOD) and malondialdehyde (MDA) contents were evaluated in this study. The McFarlane flap model was established in 20 rats and evaluated within two groups. Postoperative celiac injection was given for 7 days in the two groups: vinpocetine was applied in Group 1, and the same volume of saline was applied in Group 2.

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