3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration.

Exacerbation of osteolysis in osteoporotic bone defects presents a significant challenge for implant-based treatments. This underscores the urgent need to develop implants that actively mitigate osteolysis while simultaneously promoting bone regeneration. In this study, the osteogenic potential of mesoporous bioactive glass (MBG) and β-tricalcium phosphate (β-TCP) was combined with the anti-bone resorption property of Ga doping.

Impact of red blood cell transfusion in massive burn: a multicenter cohort study.

Blood transfusions were frequently in massive burn patients, current studies focus on the trigger threshold of red blood cell transfusion, and few studies focus on the impact of red blood cell transfusion volume on patient outcomes. We initiated a multicenter cohort study to explore the impact of red blood cell transfusions volume on patient mortality. 379 patients in three centers were enrolled to the cohort.

DP-CLAM: A weakly supervised benign-malignant classification study based on dual-angle scanning ultrasound images of thyroid nodules.

In this paper, a two-stage task weakly supervised learning algorithm is proposed. It accurately achieved patient-level classification task of benign and malignant thyroid nodules based on ultrasound images from two scanning angles: long axis and short axis of the thyroid site. In the first stage, 68,208 ultrasound scanning images of 588 patients are used to train the underlying classification model.

A new mechanism in steroid-induced osteonecrosis of the femoral head and the protective role of simvastatin.

Objective: Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating bone condition associated with femoral head collapse and hip joint dysfunction. The pathogenesis of SONFH is still not fully elucidated. This study aims to explore the role of mitochondrial cardiolipin metabolism disruption in SONFH and the potential protective effects of simvastatin (SIM).

The Role of Yes-Associated Protein in Autophagy and Tumor Progression in Gastric Cancer.

The Yes-associated protein (YAP) is a key regulator in the pathogenesis of gastric cancer (GC), yet its role in modulating autophagy remains unclear. This study investigated the effects of YAP modulation on autophagy and tumor progression using the SNU-484 and MKN-74 gastric cancer cell lines. YAP overexpression led to increased B-cell lymphoma-2 (BCL-2) transcription, reducing autophagy and enhancing cell survival, while YAP knockdown resulted in elevated autophagic activity.

A Multicenter Study of Hereditary Transthyretin Amyloidosis in China.

Objective: Hereditary transthyretin amyloidosis (ATTRv) is an autosomal dominant genetic disease characterized by the misfolding and deposition of the transthyretin (TTR) protein. This study aimed to describe the clinical and genetic characteristics of ATTRv in a large multicenter Chinese cohort.

Methods: Patients from 14 centers were included in the study.

c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation.

Pancreatic ductal adenocarcinoma remains one of the deadliest malignancies, with limited treatment options and a high recurrence rate. Recurrence happens often with metastasis, for which cancer cells must adapt to isolation stress to successfully colonize distant organs. While the fibronectin-integrin axis has been implicated in this adaptation, its regulatory mechanisms require further elaboration.

Patterns and predictors of therapeutic response to efgartigimod in acetylcholine receptor-antibody generalized myasthenia gravis subtypes.

Background: Efgartigimod is an approved biologic for generalized myasthenia gravis (gMG), which is an autoimmune disease and can potentially be life-threatening. However, the therapeutic response to efgartigimod among the acetylcholine receptor gMG (AChR-gMG) subtypes remains inconclusive.

Objective: To explore the patterns and predictors for the therapeutic response to efgartigimod among AChR-gMG subtypes.

Mutational and clinical spectrum of myofibrillar myopathy in one center from China.

Background: Myofibrillar myopathy (MFM) is a heterogeneous group of neuromuscular disorders characterized by degeneration of Z-disk and disintegration of myofibrils. OBJECTIVE: We aimed to analyze the mutational spectrum and phenotypic features of MFM in China.

Methods: We used targeted next generation sequencing (NGS) to identify causative mutations in 39 MFM patients with confirmed myopathological diagnosis.

Extending curve matching with flexible hyperparameter selection to predict response to long-acting PEGylated growth hormone treatment in growth hormone deficiency children: method development and validation.

Purpose: Curve matching can predict the height trajectories of children by analyzing longitudinal growth data. We extended the method to improve the prediction of response to long-acting growth hormone treatment in children with growth hormone deficiency (GHD).

Methods: We analyzed data from a previous real-world study with a 36-month treatment of PEGylated recombinant human growth hormone (PEG-rhGH).

Diagnostic Value of Revised Diagnostic Criteria for Thromboangiitis Obliterans (Buerger's Disease): A Cross-sectional Study.

Three deficiencies of the Papa criteria (point scoring system, PSS) for thromboangiitis obliterans (TAO) were identified and updated. According to the new criteria, 185 patients with clinically diagnosed TAO in a single center using the diagnostic criteria of Shionoya were scored and re-diagnosed. The diagnostic criteria of The Japanese Ministry of Health, Labour and Welfare (JMHLW) were used as the comparative standard to compare the diagnostic value of the revised PSS (RPSS) criteria in the diagnosis of TAO.

Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study.

Aim: To analyze whether alterations of voxel mirror homology connectivity (VMHC) values, as determined by resting-state functional magnetic resonance imaging (rs-fMRI), occur in cerebral regions of patients with hypertensive retinopathy (HR) and to determine the relationship between VMHC values and clinical characteristics in patients with HR.

Methods: Twenty-one patients with HR and 21 age-matched healthy controls (HCs) were assessed by rs-fMRI scanning. The functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC, with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic (ROC) curve analysis.

Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry.

Aim: To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage (DVH) and its correlation with clinical characteristics.

Methods: Twenty-one individuals with DVH (male/female 12/9; mean age 52.29±11.

Colonic delivery and controlled release of curcumin encapsulated within plant-based extracellular vesicles loaded into hydrogel beads.

In this study, the application of banana-derived extracellular vesicles (EVs) as natural carriers for hydrophobic nutraceuticals was investigated for the first time. Curcumin was solubilized in an amorphous state within the hydrophobic domains of the EVs in banana juice. The bioaccessibility of the curcumin was considerably higher in the curcumin-loaded EVs (CEVs) than for pure curcumin crystals.

Psychometric properties and measurement invariance of the medical staff occupational stress scale among Chinese clinical nurses.

Background: The Medical Staff Occupational Stress Scale (MSOSS) is a timely tool for the measurement of occupational stress among medical staff. It included a childhood stress dimension and seven other work-related stress dimensions. This study aimed to evaluate the psychometric properties and measurement invariance of the MSOSS using a large cohort of clinical nurses from Southeast China.

Navigating life after gastric cancer surgery: a qualitative exploration of the dyadic patient-caregiver perspective on quality of life outcomes.

Introduction: Gastric cancer (GC) families as a whole face the stressful time of cancer together, and the quality of life (QoL) of both the patient and the caregiver can be affected. Most past researchers have focused on the QoL of GC patients, but have neglected the role that caregivers play in the treatment process. The purpose of this study was to examine the factors influencing QoL of GC patients and their family caregivers, to compare the interactions and similarities and differences between the two influences, and to construct a conceptual model of the influences on QoL of GC patients and their caregivers based on the results of the study.

The clinical and neuroradiological features of hypertrophic olivary degeneration following brainstem stroke.

Objectives: Hypertrophic olivary degeneration (HOD), a rare type of trans-synaptic degeneration of the central nervous system (CNS) caused by disruption of the dentato-rubro-olivary pathway (DROP), is mainly described in the form of case reports. Our aim in this study is to summarize the clinical and imaging characteristics of patients with HOD following brainstem stroke.

Methods: A retrospective analysis was performed for all patients who were selected from electronic case databases between October 2019 and January 2024 in the Jiangxi Provincial People's Hospital and the Xinyu People's Hospital.

Vonoprazan-based quadruple therapy is non-inferior to esomeprazole-based quadruple therapy for Helicobacter pylori eradication: A multicenter, double-blind, randomized, phase 3 study.

Background: Owing to the high prevalence of antibiotic resistance in Helicobacter pylori (H. pylori) in China, bismuth-containing quadruple therapies have been recommended for H. pylori eradication.

Shape-recoverable chitosan/sodium alginate aerogels with sustained oxygen release and antibacterial activity for diabetic wound healing.

Wounds in diabetic patients are often inhibited in angiogenesis and extracellular matrix synthesis due to insufficient oxygen supply, leading to prolonged healing time. Although oxygen therapy has been shown to promote the healing of chronic wounds, its therapeutic effectiveness remains limited by high costs, complex procedures, and a lack of sustainability. In this study, we developed an aerogel composed of chitosan (CS), sodium alginate (SA), and calcium peroxide (CPO).

Reprogramming Lung Redox Homeostasis by NIR Driven Ultra-Small Pd Loaded Covalent Organic Framework Inhibits NF-κB Pathway for Acute Lung Injury Immunotherapy.

Acute lung injury (ALI) refers to damage to lung related cells, typically caused by an uncontrollable inflammatory response, and over-generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming lung redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, the simple synthesis of ultra-small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities and broad spectrum ROS scavenging, thereby promoting tissue repair for ALI immunotherapy.

Assessment of adverse events of the novel antiepileptic drug lamotrigine: a real-world pharmacovigilance study based on FAERS.

Background: Lamotrigine (LTG), a medication frequently prescribed for epilepsy. Despite its widespread use, there remains a lack of clarity regarding the drug's safety profile when used over extended periods in large patient populations. This study evaluated the safety profile of LTG using the FDA Adverse Event Reporting System (FAERS), aiming to enhance clinical decision-making.

Intratympanic steroid as salvage therapy for sudden sensorineural hearing loss: an overview of systematic reviews and meta-analyses.

Objective: To re-evaluate the published systematic reviews and meta-analyses on the efficacy and safety of intratympanic steroid therapy as a salvage treatment for sudden sensorineural hearing loss (SSNHL).

Methods: Systematic reviews and meta-analyses related to intratympanic steroid therapy for SSNHL were identified by searching both English and Chinese language databases, including OVID, The Cochrane Library, PubMed, Web of Science, Embase, CBM, WanFang, CNKI, and CSTJ. For each included study, the AMSTAR 2 appraisal tool was used to assess methodological quality, the PRISMA statement evaluated reporting quality, and the GRADE system was applied to assess the strength of evidence for primary study outcomes.

Dapagliflozin in diabetic kidney disease patients with different filtration status.

Background: Few studies have discussed the effects and mechanism of dapagliflozin on diabetic kidney disease (DKD) with different glomerular filtration rate (GFR) and systolic blood pressure (SBP). This study aimed to investigate the variation in the eGFR and proteinuria after dapagliflozin treatment in DKD patients with different filtration status and SBP levels.

Methods: First, we conducted a cross-sectional study to determined hyperfiltration threshold for the DKD trial.

Lactobacillus vaginalis alleviates DSS induced colitis by regulating the gut microbiota and increasing the production of 3-indoleacrylic acid.

Ulcerative colitis (UC) is a chronic inflammatory disorder, and its incidence is experiencing an upward trend worldwide. UC can result in gut microbiota dysbiosis, impaired intestinal epithelial barrier, and systemic inflammation, for all of which there is presently no definitive treatment available. Lactobacillus is known to regulate gut microbiota and related metabolites to intervene in the development of UC.