Clinical efficacy and potential mechanisms of acupuncture for Parkinson's disease: the role of GABAergic signaling.

Parkinson's disease (PD), a common neurodegenerative disease, seriously impacts the quality of life of patients. In recent years, research has revealed that the GABAergic signaling pathway plays an important role in the occurrence and development of PD. GABA is an important inhibitory neurotransmitter in the central nervous system (CNS), synthesized through the alpha decarboxylation reaction of glutamate (Glu) under the action of glutamic acid decarboxylase (GAD) in GABAergic neurons.

MiRNA expression profiling and clinical implications in prostate cancer across various stages.

This study aims to screen and identify microRNA (miRNA) expression profiles across different stages of prostate cancer (PCa) and benign prostatic hyperplasia (BPH) using high-throughput sequencing. The study seeks to determine whether specific miRNAs show consistent differential expression across various stages of PCa, with the goal of identifying potential biomarkers relevant to disease progression. In this study, a total of 12 specimens of PCa and BPH were collected from September 2021 to June 2022 in the Second Affiliated Hospital of Nanchang University, 330,006, P.

Construction and validation of a nomogram based on the log odds of positive lymph nodes to predict the prognosis of T1 gastric cancer.

In patients with gastric cancer (GC), metastatic progression through the lymphatic, haematogenous, peritoneal, and ovarian routes is the ultimate cause of death. We developed a nomogram to estimate cancer-specific survival (CSS) in patients with T1 gastric cancer based on log odds of positive lymph nodes (LODDS). A total of 2,221 patients from the Surveillance, Epidemiology, and End Results (SEER) database were split into training and internal validation cohorts, while an external validation cohort included 165 patients from our hospital.

Randomized Controlled Trial Assessing the Efficacy and Safety of a Liposomal Carrier for Low-Dose Dual Antiplatelet Therapy (Clopidogrel and Aspirin) in Coronary Heart Disease Patients.

Background: Coronary heart disease (CHD) is a leading cause of global mortality, and antiplatelet drugs are crucial in its treatment. Traditional therapy, however, often faces issues like inconsistent efficacy, frequent dosing, and high complication rates.

Purpose: This study aimed to develop a liposomal carrier for low-dose dual antiplatelet drugs (clopidogrel and aspirin) using nanotechnology and evaluate its efficacy and safety in CHD patients.

Mate-pair sequencing assisted prenatal counseling for a rare complex chromosomal rearrangement carrier.

Objective: This study was aimed to identify a rare complex rearrangement and assist prenatal counseling.

Method: Mate-pair sequencing (MPseq) combined with karyotypes, copy number variants sequencing and whole exome sequencing was used to provide accurate chromosome breakpoints and assist prenatal diagnosis for a mentally retarded pregnant woman.

Result: MPseq indicated a complex rearrangement involved 25 breakpoints and fusions, disrupting 6 genes.

Long-term survival analysis after radical gastrectomy for Epstein-Barr virus-associated gastric cancer: A multicenter study.

Background: The prognosis of Epstein-Barr virus-associated gastric cancer (EBVaGC)needs to be validated by high-quality studies. This study aimed to assess the long-term survival of EBVaGC patients after radical gastrectomy using multicenter data to explore the potential value of EBV infection status as a prognostic predictor.

Methods: We analyzed the clinical data of patients with EBVaGC and Epstein-Barr virus-negative gastric cancer (EBVnGC) who underwent radical gastrectomy from January 2013 to July 2020.

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis.

Purpose: The purpose of this study was to explore the underlying mechanism that Th17-like T follicular helper cells (Tfh) orchestrated by STING signaling have a pathogenic role in experimental autoimmune uveitis (EAU).

Methods: The differences of transcriptome and gene ontology (GO) pathway of Tfh between EAU and control mice were analyzed by single-cell RNA sequence (scRNA-seq) and bulk RNA sequence. Additionally, draining lymph nodes (DLNs) were extracted to verify the expression of IL-17A and IFN-γ in Tfh from EAU and control mice by flow cytometry.

Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy.

Diabetes mellitus is a common chronic metabolic disease, with its prevalence escalating annually. Diabetic cardiomyopathy is a leading cause of mortality among diabetic patients, characterized by intricate metabolic disturbances and myocardial cell demise. Various forms of cellular death pathways including apoptosis, pyroptosis, autophagic cell death, necroptosis, ferroptosis, and entosis have been identified in diabetic cardiomyopathy.

Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps.

Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of registered biologics for CRSwNP treatment in China, the country is experiencing rapid development in this field. It is imperative to standardize the application of biologic agents in CRSwNP management in preparation for their future integration into the CRSwNP care pathway.

Effects of dexmedetomidine combined with intravenous general anesthesia on hemodynamics and inflammatory factors in patients undergoing laparoscopic colorectal cancer surgery.

Introduction: Surgery is the principal treatment option for early colorectal cancer (CRC). Anesthesia plays a crucial role in any surgery as it allows for a painless procedure. Dexmedetomidine is a local anesthetic that reduces pain and discomfort during surgery.

Correlation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study.

Corticosteroids (CSs) are the initial therapy for immune thrombocytopenia (ITP); however, their efficacy is not adequately predicted. As a novel biomarker, the composition of the gut microbiota is non-invasively tested and altered in patients with ITP. This study aims to develop a predictive model that leverages gut microbiome data to predict the CS response in patients with ITP within the initial four weeks of treatment.

Multiple mechanisms and applications of tertiary lymphoid structures and immune checkpoint blockade.

Background: Immune checkpoint blockade (ICB) inhibits tumor immune escape and has significantly advanced tumor therapy. However, ICB benefits only a minority of patients treated and may lead to many immune-related adverse events. Therefore, identifying factors that can predict treatment outcomes, enhance synergy with ICB, and mitigate immune-related adverse events is urgently needed.

Exploring the clinical outcomes and molecular characteristics of bloodstream infections: a study of sequence types, capsular types, and drug resistance in China.

Background: Bloodstream infections (BSIs) caused by have been associated with high mortality. To improve the outcomes of patients, this study explored the clinical characteristics and outcomes of patients with BSIs, as well as the phenotypic and genomic characteristics of these isolates.

Methods: A retrospective cohort study was conducted involving BSIs cases from 2020 to 2023 in a tertiary hospital.

Association between dementia, Alzheimer's disease, and liver cancer: A Mendelian randomization analysis.

Background: Epidemiological studies have indicated an inverse association between neurodegenerative diseases and cancer. However, the relationship between liver cancer and dementia, particularly Alzheimer's disease (AD), remains underexplored.

Objective: This study aimed to determine the association between dementia, specifically AD, and liver cancer using Mendelian randomization (MR) analysis.

NLRP3-inflammasome Related Genes as Emerging Biomarkers and Therapeutic Targets in Psoriasis.

The NLRP3 inflammasome is closely associated with inflammatory diseases, including psoriasis. Objective diagnostic biomarkers and alternative therapies for psoriasis remain limited. We aimed to identify reliable biomarkers for the diagnosis of psoriasis and investigate potential therapy strategies.

Outperforming Traditional Staging: A Novel Nomogram for HR-Positive Breast Cancer.

Background: Hormone receptor-positive breast cancer (HR-positive BC), the most prevalent subtype, typically has a favorable prognosis. However, treatment decision-making and survival prediction remain challenging due to the limitations of traditional staging systems like AJCC. Improved prognostic tools are needed to enhance individualized risk stratification.

The Impact of Prostate-Specific Antigen and Gleason Scores on Cardiovascular Death in Prostate Cancer Patients after Radiotherapy or Chemotherapy: A Population-Based Study.

Background: Tumor characteristics are associated with the risk of cardiovascular death (CVD) in cancer patients. However, the influence of tumor characteristics on CVD risk among prostate cancer (PC) patients who have received radiotherapy (RT) or chemotherapy (CT) is often overlooked. This study explored the association between PC tumor characteristics and CVD risk in PC patients who had received RT or CT.

Elevated atherogenic index of plasma is associated with increased cardiorenal syndrome prevalence: a cross-sectional study.

Purpose: Cardiorenal syndrome (CRS) is a complex clinical condition characterized by the simultaneous dysfunction of the heart and kidneys. The atherogenic index of plasma (AIP), calculated as the logarithm of the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C), has emerged as a potential biomarker for cardiovascular risk. This study investigates the association between AIP and CRS, aiming to explore the potential linkage between AIP and CRS.

Predicting 30-day mortality in hemophagocytic lymphohistiocytosis: clinical features, biochemical parameters, and machine learning insights.

This study aims to evaluate the clinical characteristics and biochemical parameters of hemophagocytic lymphohistiocytosis (HLH) patients to predict 30-day mortality. Parameters analyzed include lymphocyte count (L), platelet count (PLT), total protein (TP), albumin (ALB), blood urea nitrogen (BUN), and activated partial thromboplastin time (APTT). Machine learning (ML) approaches, including LASSO, random forest (RF), and support vector machine (SVM), were employed alongside meta-analysis and sensitivity analysis to validate the prognostic potential of these indicators.

Expert consensus on intentional tooth replantation.

Intentional tooth replantation (ITR) is an advanced treatment modality and the procedure of last resort for preserving teeth with inaccessible endodontic or resorptive lesions. ITR is defined as the deliberate extraction of a tooth; evaluation of the root surface, endodontic manipulation, and repair; and placement of the tooth back into its original socket. Case reports, case series, cohort studies, and randomized controlled trials have demonstrated the efficacy of ITR in the retention of natural teeth that are untreatable or difficult to manage with root canal treatment or endodontic microsurgery.

Comparative Analysis of Surgery Using Combined Iliac Lumbar and Posterior Closed Screws for Pelvic Stability Maintenance.

BACKGROUND Pelvic fractures are prevalent complex fractures in traumatic orthopedics that tend to lead to an unstable posterior pelvic ring. This study aimed to analyze and compare the clinical efficacy of combined iliolumbar screws and posterior closure screws in the treatment of pelvic instability. MATERIAL AND METHODS Thirteen (study group) and 22 (control group) patients were treated with combined iliac lumbar screws and posterior closed screws, respectively.

Time-Sensitive Antibiotic Adjustments in Gram-Negative Bacteremia: A Survival Perspective.

BACKGROUND This retrospective study was designed to assess risk factors for increased 30-day mortality from bacteremia caused by Escherichia coli or Klebsiella pneumoniae and to calculate the optimal point of time for patients to move from inappropriate empirical antimicrobial therapy to appropriate treatment. MATERIAL AND METHODS This retrospective study analyzed data from 610 patients with a diagnosis of E. coli- and K.