291 results match your criteria: "The Sakakibara Heart Institute of Okayama.[Affiliation]"

Article Synopsis
  • Older patients with heart failure (HF) experience a higher risk of developing pneumonia, which contributes to increased mortality rates.
  • A study of 1,266 hospitalized patients aged 65 and older found that those with low muscle strength were significantly more likely to develop pneumonia post-discharge.
  • Low muscle strength was identified as a strong predictor of pneumonia and associated with a fourfold increased risk of death after pneumonia onset.
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Prognostic Value of Sarcopenia Definitions and Outcomes Consortium Criteria in Older Patients with Heart Failure.

J Am Med Dir Assoc

November 2024

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Tokyo, Japan.

Objectives: The Asian Working Group for Sarcopenia in 2019 (AWGS 2019) emphasized muscle mass measurements. In contrast, the Sarcopenia Definitions and Outcomes Consortium (SDOC) prioritizes functional strength and mobility. Therefore, this study aimed to compare the prognostic utility of the SDOC and AWGS 2019 criteria for all-cause mortality in older patients with heart failure.

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Validation of Left Ventricular Filling Pressure Evaluation by Order of Tricuspid and Mitral Valve Opening in Patients With Atrial Fibrillation.

Circ Cardiovasc Imaging

November 2024

Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan.

Article Synopsis
  • Accurate assessment of left ventricular filling pressure in patients with atrial fibrillation is challenging, but a new scoring system called VMT score can visually assess valve opening timings to evaluate this pressure.
  • In a study with 119 patients, the VMT score showed a strong correlation with elevated pulmonary arterial wedge pressure and had a diagnostic accuracy of 87%, outperforming traditional Doppler methods.
  • The findings were validated in a separate group of 189 patients, confirming that a VMT score of 2 or higher indicates significant left ventricular filling pressure elevation, making it a potentially valuable tool in clinical settings.
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Background: Data on the impact of valve position on clinical outcomes in patients with atrial fibrillation (AF) and bioprosthetic valves (BPVs) are limited.

Methods And Results: The BPV-AF Registry was a multicenter, prospective, observational study involving 894 patients with BPVs and AF. In this post-hoc substudy, patients were classified according to BPV position: aortic (n=588; 65.

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Article Synopsis
  • The study explores the prevalence of cachexia, sarcopenia, and malnutrition in older patients with heart failure (HF) using definitions from the Asian Working Group for Cachexia (AWGC) and other criteria, finding that AWGC-defined cachexia was the most common condition.
  • Among the 861 patients analyzed, cachexia was present in 74.1%, while other conditions showed lower prevalence rates.
  • The results indicated that AWGC-defined cachexia was not significantly linked to all-cause mortality in these patients, contrasting with stronger associations found for cachexia according to Evans' criteria, sarcopenia, and malnutrition.
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Article Synopsis
  • Older patients (65+) with heart failure (HF) often experience physical frailty and malnutrition, which can worsen each other and lead to poor health outcomes.
  • A study involving 862 hospitalized patients found that those with both frailty and malnutrition had the highest risk of death within a year of discharge compared to those with neither condition.
  • Identifying and addressing both frailty and malnutrition in these patients is essential for improving their overall health and survival rates.
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Aneurysms of the tibioperoneal trunk (TPT) with peripheral arterial lesions are extremely rare. We present a case of a 68-year-old man who underwent surgical treatment for a mycotic aneurysm of the TPT. This report highlights the importance of en bloc surgical resection of the mycotic aneurysm and an appropriate approach with an air tourniquet for the prevention of injuries to the adherent tissues.

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Ultrasound-measured Quadriceps Muscle Thickness and Mortality in Older Patients With Heart Failure.

Can J Cardiol

December 2024

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Cardiology, The Sakakibara Heart Institute of Okayama, Okayama, Japan.

Article Synopsis
  • Ultrasound measurements of quadriceps muscle thickness (QMT) can be effectively used to assess muscle mass in older heart failure patients, particularly those aged 65 and above.
  • *The study involved 595 hospitalized patients, where QMT was measured with high reliability, demonstrating excellent agreement between different observers.
  • *Findings indicate that lower height-adjusted QMT is linked to higher mortality rates, highlighting its potential as a prognostic tool in heart failure management.*
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Aims: The 6-min walk test (6MWT) is a widely accepted tool for evaluating exercise tolerance and physical capacity, and the 6-min walk distance (6MWD) is an established prognostic factor in patients with heart failure (HF). However, the prognostic implications of post-6MWT dyspnoea remain unknown. We aimed to investigate the prognostic value of Borg scores after the 6MWT in patients with HF.

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Usefulness of hypochloremia at the time of discharge to predict prognosis in patients with chronic heart failure after hospitalization.

J Cardiol

August 2024

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Tokyo, Japan.

Article Synopsis
  • Hypochloremia, defined as low chloride levels in the blood, is linked to higher mortality rates in heart failure (HF) patients and was studied to see if it enhances existing prognostic models.
  • In a study of 2,496 hospitalized HF patients, those with hypochloremia had a significantly higher 1-year mortality rate (12.6% of patients had hypochloremia, with 15.5% deaths observed).
  • Adding hypochloremia to established risk models improved predictive accuracy, suggesting it can provide valuable insights into patient outcomes post-discharge.
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Prognostic Impact of Sarcopenia Assessed Using Modified Asian Working Group for Sarcopenia 2019 Criteria in Heart Failure.

Can J Cardiol

December 2024

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology (AMED-CREST), Tokyo, Japan.

Background: Sarcopenia is a substantial therapeutic target, yet the validity of risk stratification values per the latest Asian Working Group for Sarcopenia in 2019 (AWGS 2019) remains unconfirmed in patients with heart failure. We hypothesized that using the 6-minute walk test (6MWT) to assess physical performance improves risk stratification.

Methods: The study included 832 hospitalized patients with heart failure who could walk at discharge.

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Article Synopsis
  • The study investigates the R-CHADS-VASc score's ability to predict cardiovascular events in atrial fibrillation (AF) patients post bioprosthetic valve replacement, using data from the BPV-AF registry with 766 participants.
  • Patients were classified into low, moderate, and high risk based on their R-CHADS-VASc scores, with results indicating that those with higher scores experienced significantly more cardiovascular events during the follow-up period.
  • The findings suggest that the R-CHADS-VASc score is an effective tool for assessing cardiovascular risk in AF patients who have undergone BPV replacement, with higher scores correlating to worse outcomes.
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Iatrogenic inferior vena cava (IVC)-left atrium (LA) shunt is a rare complication in atrial septal defect (ASD) surgery, caused by mistaking the Eustachian valve for the lower margin of the ASD. In this report, we describe the case of a 45-year-old woman who experienced circulatory collapse at termination of cardiopulmonary bypass during surgical IVC-LA shunt repair. Transesophageal echocardiography helped identify stenosis between the IVC and the right atrium, caused by a residual original incorrectly placed ASD patch.

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Background: Weight loss is a poor prognostic factor in patients with chronic heart failure (HF). However, whether the same is true for hospitalized patients with HF is unknown, even though hospitalization is the first opportunity for many patients to be diagnosed with HF. This study aimed to investigate the prognostic value of weight loss in patients hospitalized for HF.

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Article Synopsis
  • Current guidelines suggest using either DOACs or warfarin for patients with atrial fibrillation who have a bioprosthetic valve, but research on elderly patients (≥80 years) in this context is limited.
  • A study analyzed data from 752 patients, revealing that those aged ≥80 had a significantly higher risk of adverse outcomes than younger patients, with a hazard ratio of 2.04.
  • The findings indicate that both DOACs and warfarin have comparable efficacy and safety in managing elderly patients with bioprosthetic valves and atrial fibrillation.
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Aims: In heart failure (HF), inflammation is linked to malnutrition and impaired physical function. In this study, we aimed to assess how novel nutritional-inflammatory markers and lymphocyte-to-C-reactive protein ratio (LCR) and score (LCS) are associated with the nutritional status, physical function, and prognosis of patients with HF.

Methods And Results: This study was a secondary analysis of the FRAGILE-HF study, a prospective observational study conducted across 15 hospitals in Japan.

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Objective: Trans-catheter aortic valve implantation inside a failing surgical aortic valve bio-prosthesis has become an alternative for patients at high risk for redo surgical aortic valve replacement. However, the correlation between the size of the failing surgical aortic valve and the occurrence of prosthesis-patient mismatch after trans-catheter implantation is still controversial. The aim of this study is to analyze and report the results in Japanese patients.

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Background: Excimer laser coronary angioplasty (ELCA) is utilized to reduce thrombus in acute coronary syndrome (ACS). However, the feasibility and safety of ELCA for patients with ACS involving the left main trunk (LMT) and bifurcation, as well as the safety of a stentless strategy with ELCA, are not well-documented.

Case Summary: A 37-year-old man without any past medical history presented with chest pain.

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Background: Social factors encompass a broad spectrum of nonmedical factors, including objective (social isolation [SI]) and perceived (loneliness) conditions. Although social factors have attracted considerable research attention, information regarding their impact on patients with heart failure is scarce. We aimed to investigate the prognostic impact of objective SI and loneliness in older patients with heart failure.

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In recent years, bedside ultrasound examinations have been used in many clinical departments and are called point-of-care ultrasound (POCUS). Regarding POCUS in the cardiac field, a protocol called focus (focused) cardiac ultrasound (FoCUS) has been developed in Europe and the United States, is being used clinically, and an educational syllabus has been created. According to them, FoCUS is defined as a point-of-care cardiac ultrasound examination using standardized limited sections and protocols.

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Objective: There is a need for a robust tool to stratify the patient's risk with COVID-19. We assessed the prognostic values of cardiac biomarkers for COVID-19 patients.

Methods: This is a single-centre retrospective cohort study.

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Aims: This study aimed to investigate the prevalence, clinical characteristics, and prognostic value of bendopnea in older patients hospitalized for heart failure.

Methods And Results: This post hoc analysis was performed using two prospective, multicentre, observational studies: the FRAGILE-HF (main cohort) and SONIC-HF (validation cohort) cohorts. Patients were categorized based on the presence of bendopnea, which was evaluated before discharge.

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Impact of Multidomain Frailty on the Mode of Death in Older Patients With Heart Failure: A Cohort Study.

Circ Cardiovasc Qual Outcomes

May 2024

Japan Agency for Medical Research and Development-Core Research for Evolutionary Medical Science and Technology, Japan Agency for Medical Research and Development, Tokyo, Japan (T.M.).

Article Synopsis
  • Frailty in elderly heart failure patients correlates with overall mortality, but specific causes of death remain underexplored, prompting further investigation into multidomain frailty's role.
  • The study analyzed 1,181 hospitalized patients, finding that as frailty increased (measured across physical, social, and cognitive domains), so did the risk of death, particularly from noncardiovascular causes.
  • Results indicated that patients with higher frailty scores (2 or 3 domains) had a significantly increased risk of noncardiovascular death, while the association was not as strong for heart failure or other cardiovascular deaths.
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Aims: Although systolic expansion of the annulus has been recognized in Barlow's disease, the mechanisms of the unique pathological movement of the annulus and its relation to the leaflet augmentation have not yet been clarified. We aimed to investigate the detailed mechanisms of the characteristic mitral apparatus dynamics in Barlow's disease by frame-by-frame sequential geometric analysis using real-time 3D transoesophageal echocardiography.

Methods And Results: Fifty-three patients with Barlow's disease and severe mitral regurgitation without torn chordae, as well as 10 controls, were included.

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