262 results match your criteria: "The Royal's Institute of Mental Health Research[Affiliation]"

Integrated youth service (IYS) is a collaborative approach that brings practitioners together from across disciplines to provide comprehensive services including mental health care for youth and their families. IYS models serve as an advancement in practice as they go beyond the capacity of individual programs and services to reduce the fragmentation of care. Yet, there continue to be opportunities to expand on this perspective and promote health beyond the scope of formalized services.

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Cognitive control and (cognitive) flexibility play an important role in an individual's ability to adapt to continuously changing environments. In addition to facilitating goal-directed behaviors, cognitive control and flexibility have been implicated in emotion regulation, and disturbances of these abilities are present in mood and anxiety disorders. In the context of stressful experiences, the reported studies examined processes related to cognitive control and flexibility, emotional regulation and depressive symptoms.

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Resting state network (RSN) functional connectivity (FC) has been investigated under a wealth of different healthy and compromised conditions. Such investigations are often dependent on the defined spatial boundaries and nodes of so-called canonical RSNs, themselves the product of extensive deliberations over distinctions between functional magnetic resonance imaging (fMRI) noise and neural signal, specifically in the context of the healthy waking state. However, a similar unbiased cataloging of noise and networks remains to be done in other states, particularly sleep, a healthy alternate mode of the brain that supports distinct operations from wakefulness, such as dreaming and memory consolidation.

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Amnestic mild cognitive impairment (aMCI) often corresponds to the prodromal stage of Alzheimer disease (AD). The aMCI stage represents a crucial time window to apply preventive interventions in an attempt to delay cognitive decline. Stress, one of AD's modifiable risk factors frequently co-occurring with aMCI, stands out as a key intervention target.

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Neuronal variability of Resting State activity in Eating Disorders: increase and decoupling in Ventral Attention Network and relation with clinical symptoms.

Eur Psychiatry

January 2019

The Royal's Institute of Mental Health Research & University of Ottawa Brain and Mind Research Institute, Centre for Neural Dynamics, Faculty of Medicine, University of Ottawa, 145 Carling Avenue, Rm. 6435, Ottawa, ON, K1Z 7K4 Canada.

Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices.

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Study Objectives: The behavioral and cognitive consequences of severe sleep deprivation are well understood. Surprisingly, relatively little is known about the neural correlates of mild and acute sleep restriction on tasks that require sustained vigilance for prolonged periods of time during the day.

Methods And Results: Event-related potential (ERP) paradigms can reveal insight into the neural correlates underlying visual processing and behavioral responding that is impaired with reduced alertness, as a consequence of sleep loss.

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Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders.

Transl Psychiatry

October 2018

Clinical Research Unit, Brain & Mind Centre, The University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia.

Abnormalities in circadian rhythms have been reported in people with mood disorders, but these abnormalities are marked by considerable inter-individual variability. This study aimed to identify pathophysiological subgroups on the basis of circadian markers and evaluate how these subgroups relate to psychiatric profiles. Thirty-five young adults (18-31 years old) receiving clinical care for unipolar depressive disorders and 15 healthy controls took part to this study.

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Interventions for common mental health problems among university and college students: A systematic review and meta-analysis of randomized controlled trials.

J Psychiatr Res

December 2018

Work & Mental Health Research Unit, The Royal's Institute of Mental Health Research, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Canada; School of Psychology, Faculty of Social Sciences, University of Ottawa, Canada; Department of Psychiatry, Faculty of Medicine, University of Ottawa, Canada. Electronic address:

Common mental health problems (CMHPs), such as depression, anxiety disorder, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD) are internalizing disorders with high comorbidity. University and college students are under many stressors and transitional events, and students fall within the age range when CMHPs are at their developmental peak. Compared to the expanded effort to explore and treat CMHPs, there has been no a meta-analysis that comprehensively reviewed the interventions for CMHPs and examined the effects of interventions for CMHPs in college students.

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Decision making based on behavioral and neural observations of living systems has been extensively studied in brain science, psychology, neuroeconomics, and other disciplines. Decision-making mechanisms have also been experimentally implemented in physical processes, such as single photons and chaotic lasers. The findings of these experiments suggest that there is a certain common basis in describing decision making, regardless of its physical realizations.

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Bipolar disorder (BD) is a complex psychiatric disorder characterized by dominant symptom swings across different phases (manic, depressive, and euthymic). Different symptoms in BD such as abnormal episodic memory recall and psychomotor activity have been related to alterations in different regions, ie, hippocampus and motor cortex. How the abnormal regional distribution of neuronal activity relates to specific symptoms remains unclear, however.

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The juvenile period is marked by a reorganization and growth of important brain regions including structures associating with reward seeking behaviors such as the nucleus accumbens (NA) and prefrontal cortex (PFC). These changes are impacted by stressors during the juvenile period and may lead to a predisposition to stress induced psychopathology and abnormal development of brain reward systems. Like in humans, adult rodents engage certain coping mechanisms such as increases in the consumption of calorie-rich palatable foods to reduce stress, but this behavior can lead to obesity and metabolic disorders.

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We examined the latent structure and taxonicity of hypersexuality in large university and community samples of male and female respondents. Participants completed the Hypersexual Behavior Inventory (HBI) and Sexual Compulsivity Scale (SCS), each as part of larger anonymous online surveys of sexual behavior. Exploratory factor analyses (EFA) were performed in part to prepare the data for taxometric analysis and also to identify the putative dimensions underpinning each measure.

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Objectives: In 2016, the Canadian Centre on Substance Use and Addiction (CCSA) conducted the first survey of individuals in recovery from addiction in Canada. The findings revealed that many individuals in recovery lead meaningful lives, contributing to their families and society. However, participants also identified a number of barriers to starting and maintaining recovery.

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Can dreams reveal insight into our cognitive abilities and aptitudes (i.e., "human intelligence")? The relationship between dream production and trait-like cognitive abilities is the foundation of several long-standing theories on the neurocognitive and cognitive-psychological basis of dreaming.

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Objectives: The (the Standard) was released in 2013. The objectives of this study were to 1) estimate the proportion of Canadian employers who were aware of the Standard, 2) examine the extent to which the Standard has been implemented, and 3) describe perceived barriers to implementing the Standard in Canadian organizations.

Methods: A cross-sectional survey in Canadian employers was conducted between February 2015 and January 2017.

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The present research explored whether components of social identity, namely ingroup ties, affect, and centrality, were differentially linked to mental health and inflammatory immune responses, and whether rumination mediated those relations. Study 1 (N = 138) indicated that stronger ingroup ties were associated with fewer mental health (depressive and post-traumatic stress) symptoms; those relations were mediated by the tendency for individuals with strong ties to rely less on ruminative coping to deal with a stressful life event. Study 2 (N = 54) demonstrated that ingroup ties were negatively associated with depressive symptoms, dispositional rumination, as well as stress-linked inflammatory elements at the physiological level.

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Research suggests sleep plays a role in the consolidation of recently acquired memories for long-term storage. rapid eye movement (REM) sleep has been shown to play a complex role in emotional-memory processing, and may be involved in subsequent waking-day emotional reactivity and amygdala responsivity. Interaction of the hippocampus and basolateral amygdala with the medial-prefrontal cortex is associated with sleep-dependent learning and emotional memory processing.

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A Perceptual Inference Mechanism for Hallucinations Linked to Striatal Dopamine.

Curr Biol

February 2018

Department of Psychiatry, New York State Psychiatric Institute, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA. Electronic address:

Hallucinations, a cardinal feature of psychotic disorders such as schizophrenia, are known to depend on excessive striatal dopamine. However, an underlying cognitive mechanism linking dopamine dysregulation and the experience of hallucinatory percepts remains elusive. Bayesian models explain perception as an optimal combination of prior expectations and new sensory evidence, where perceptual distortions such as illusions and hallucinations may occur if prior expectations are afforded excessive weight.

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Viewing time tasks using still pictures to assess age and gender sexual interests have been well validated and are commonly used. The use of film clips in a viewing time task would open up interesting possibilities for the study of sexual interest toward sexual targets or activities that are not easily captured in still pictures. We examined the validity of a viewing time task using film clips to assess sexual interest toward male and female targets, in a sample of 52 young adults.

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Gastrin-releasing peptide attenuates fear memory reconsolidation.

Behav Brain Res

July 2018

School of Psychology, University of Ottawa, Canada; Faculty of Medicine, University of Ottawa, Canada; The Royal's Institute of Mental Health Research affiliated with the University of Ottawa, Canada. Electronic address:

Background: Gastrin Releasing Peptide (GRP) may play a role in fear learning. The GRP Receptor is expressed in the basolateral amygdala and hippocampus, and central administration of GRP mediates fear learning. The effects of GRP on reconsolidation, however, have been minimally explored.

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[Genuine motor phenomena in schizophrenia : Neuronal correlates and pathomechanisms].

Nervenarzt

January 2018

Zentrum für Psychosoziale Medizin, Klinik für Allgemeine Psychiatrie, Universität Heidelberg, Heidelberg, Deutschland.

Despite a growing body of evidence on motor dysfunction in schizophrenia spectrum disorders, the neuronal correlates of genuine motor abnormalities (GMA) are not fully elucidated at present. Moreover, the clinical relevance of a potential "motor intermediate phenotype" remains controversial. This systematic review aims at characterizing a "motor intermediate phenotype" in schizophrenia spectrum disorders.

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How spontaneous brain activity and narcissistic features shape social interaction.

Sci Rep

August 2017

Department of Neuroscience, Imaging and Clinical Sciences, G. d'Annunzio University of Chieti-Pescara, Via dei Vestini 33, 66013, Chieti, (CH), Italy.

There is an increasing interest in how ongoing spontaneous brain activity and personality provide a predisposition for the processing of environmental demands. It further has been suggested that the brain has an inherent sensitivity to the social environment. Here we tested in healthy volunteers if spontaneous brain activity contributes to a predisposition for social behavior and how this is modulated by narcissistic personality features associated with poor interpersonal functioning.

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This study examined the relations among women's experiences of abuse, forgiveness, revenge, psychological health, and physiological stress reactivity. Both dispositional (Study 1;  = 103) and state (Study 2;  = 258) forgiveness and vengeance were associated with psychological symptoms. However, the relation between revenge and greater depression was magnified among psychologically abused women, whereas-unexpectedly-the positive link between forgiveness and psychological health was strengthened among physically abused women.

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