261 results match your criteria: "The Royal's Institute of Mental Health Research[Affiliation]"

Background: The Truth and Reconciliation Commission of Canada called upon health professional programs to teach about historical and on-going colonalism. Since these calls to action, there has been an increase in educational opportunities on the topic. Although it is generally assumed that learning about colonialism will reduce racism and improve allyship towards Indigenous Peoples, an evaluation of this assumption is needed.

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Connecting brain and mind through temporo-spatial dynamics: Towards a theory of common currency.

Phys Life Rev

November 2024

Department of Philosophy, Sociology, Education, and Applied Psychology, University of Padova, Italy. Electronic address:

Despite major progress in our understanding of the brain, the connection of neural and mental features, that is, brain and mind, remains yet elusive. In our 2020 target paper ("Is temporospatial dynamics the 'common currency' of brain and mind? Spatiotemporal Neuroscience") we proposed the "Common currency hypothesis": temporo-spatial dynamics are shared by neural and mental features, providing their connection. The current paper aims to further support and extend the original description of such common currency into a first outline of a "Common currency theory" (CCT) of neuro-mental relationship.

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The human brain is tightly connected to the individual's environment and its input dynamics. How the dynamics of periodic environmental stimuli influence neural activity and subsequent behavior via neural entrainment or alignment is not fully clear yet, though. This study explores how periodic environmental stimuli influence neural activity and behavior.

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Non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) or transcranial magnetic stimulation (TMS) have made great progress in recent years and offer boundless potential for the neuroscientific research and treatment of disorders. However, the possible use of NIBS devices for neuro-doping and neuroenhancement in healthy individuals and the military are poorly regulated. The great potentials and diverse applications can have an impact on the future development of the technology and society.

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Spectral peak analysis and intrinsic neural timescales as markers for the state of consciousness.

Neuroimage Clin

November 2024

University of Ottawa, The Royal's Institute of Mental Health Research, Brain and Mind Research Institute, Ottawa K1Z 7K4 ON, Canada.

Resting state EEG in patients with disorders of consciousness (DOC) is characterized by an increase of power in the delta frequency band and a concurrent decrease in the alpha range, equivalent to a weakening or disappearance of the alpha peak. Prolongation of Intrinsic Neural Timescales (INTs) is also associated with DOCs. Together, this raises the question whether the decreased alpha peak relates to the prolonged INTs and, importantly, how that can be used for diagnosing the state of consciousness in DOC individuals.

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Associations of self-regulation strategy use with in-play betting intensity and associated harms: An ecological momentary assessment study.

Addict Behav

October 2023

Department of Psychology, University of Calgary, Calgary, AB, Canada; The Royal's Institute of Mental Health Research, University of Ottawa, Canada. Electronic address:

Self-regulation strategies, such as limit setting, can be effective in reducing harms associated with gambling. However, limited research has examined their applicability to in-play sports betting. The current study therefore examined the utility of self-regulation strategies in reducing in-play betting intensity and associated harms.

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Catatonia: What Else Matters?

Mov Disord

October 2024

Mind, Brain Imaging and Neuroethics Research Unit, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.

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Personal brain and Spatiotemporal Psychopathology - Intrinsic vs. extrinsic sources of interindividual variability.

Mol Psychiatry

October 2024

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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Article Synopsis
  • It can be hard to figure out if taking mental health medications during pregnancy is safe for both the mom and the baby.
  • Researchers looked at a lot of studies to see if these medications cause any health problems for pregnant people or their babies.
  • They found some evidence that certain medications might lead to issues like preterm birth or birth defects, but overall, there wasn’t strong proof that taking these medications is dangerous during pregnancy.
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Optimizing antidepressant benefits: Effect of theta burst stimulation treatment in physically active people with treatment-resistant depression.

J Affect Disord

December 2024

The Royal's Institute of Mental Health Research, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada; The University of Ottawa Brain and Mind Research Institute, Roger Guindon Hall, 451 Smyth Rd #2044, Ottawa, ON K1H 8M5, Canada; Département de psychoéducation et de psychologie, Université du Québec en Outaouais, 283 Alexandre-Taché Boul, Gatineau, QC J8X 3X7, Canada; Department of Neuroscience, Carleton University, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd #2044, Ottawa, ON K1H 8M5, Canada. Electronic address:

Theta burst stimulation (TBS) is a promising therapy for treatment-resistant major depressive disorder (MDD), but a significant proportion of individuals do not respond adequately, necessitating alternative approaches. This study explores whether individuals meeting minimum recommended physical activity levels demonstrate better responses to TBS compared to physically inactive individuals. Using data from a randomized controlled trial (n = 43), participants were categorized as physically active or inactive based on baseline International Physical Activity Questionnaire (IPAQ) scores.

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Physiological fitness in people with advanced multiple sclerosis.

Mult Scler Relat Disord

November 2024

Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada; The University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada. Electronic address:

Introduction: Physiological fitness, encompassing cardiorespiratory fitness (CRF) and body composition, are important markers of overall health, functional capacity, and quality of life in general and clinical populations. Characterizing fitness is important for the development of tailored interventions and strategies to optimize well-being across the spectrum of disability in multiple sclerosis (MS). While existing research has explored fitness in people with mild-to-moderate disability, there is a scarcity of data in people with advanced MS (Expanded Disability Severity Scale, EDSS≥7.

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Objective: Investigate excitatory-inhibitory (E/I) (im)balance using transcranial magnetic stimulation (TMS) in individuals with Multiple Sclerosis (MS) and determine its validity as a neurophysiological biomarker of disability.

Methods: Participants with MS (n = 83) underwent TMS, cognitive, and motor function assessments. TMS-induced motor evoked potential amplitudes (excitability) and cortical silent periods (inhibition) were assessed bilaterally through recruitment curves.

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Brain and breathing activities are closely related. However, the exact neurophysiological mechanisms that couple the brain and breathing to stimuli in the external environment are not yet agreed upon. Our data support that synchronization and dynamic attunement are two key mechanisms that couple local brain activity and breathing to external periodic stimuli.

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Altered hippocampal morphology and metabolic pathology, but also hippocampal circuit dysfunction, are established phenomena seen in psychotic disorders. Thus, we tested whether hippocampal subfield volume deficits link with deviations in glucose metabolism commonly seen in early psychosis, and whether the glucose parameters or subfield volumes change during follow-up period using one-year longitudinal study design of 78 first-episode psychosis patients (FEP), 48 clinical high-risk patients (CHR) and 83 controls (CTR). We also tested whether hippocampal morphology and glucose metabolism relate to clinical outcome.

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Correction: Is depression a global brain disorder with topographic dynamic reorganization?

Transl Psychiatry

July 2024

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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Intrinsic neural timescales exhibit different lengths in distinct meditation techniques.

Neuroimage

August 2024

The Royal's Institute of Mental Health Research & University of Ottawa, Brain and Mind Research Institute, Centre for Neural Dynamics, Faculty of Medicine, University of Ottawa, 145 Carling Avenue, Rm. 6435, Ottawa K1Z 7K4, ON, Canada. Electronic address:

Meditation encompasses a range of practices employing diverse induction techniques, each characterized by a distinct attentional focus. In Mantra meditation, for instance, practitioners direct their attention narrowly to a given sentence that is recursively repeated, while other forms of meditation such as Shoonya meditation are induced by a wider attentional focus. Here we aimed to identify the neural underpinnings and correlates associated with this spectrum of distinct attentional foci.

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The subcortical brain regions influence the cortical areas during resting-state: an fMRI study.

Front Hum Neurosci

June 2024

Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Numerous modes or patterns of neural activity can be seen in the brain of individuals during the resting state. However, those functions do not persist long, and they are continuously altering in the brain. We have hypothesized that the brain activations during the resting state should themselves be responsible for this alteration of the activities.

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Background: Schizophrenia spectrum disorders (SSDs) are a group of psychiatric disorders characterized by positive and negative symptoms as well as cognitive impairment that can significantly affect daily functioning.

Method: We reviewed evidence-based strategies for improving cognitive function in patients with SSDs, focusing on the Canadian landscape.

Results: Although antipsychotic medications can address the positive symptoms of SSDs, cognitive symptoms often persist, causing functional impairment and reduced quality of life.

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Catatonia.

Nat Rev Dis Primers

July 2024

Mind, Brain Imaging and Neuroethics Research Unit, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.

Catatonia is a neuropsychiatric disorder characterized by motor, affective and cognitive-behavioural signs, which lasts from hours to days. Intensive research over the past two decades has led to catatonia being recognized as an independent diagnosis in the International Classification of Diseases, 11th Revision (ICD-11) since 2022. Catatonia is found in 5-18% of inpatients on psychiatric units and 3.

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Philosophy in psychiatry: Sparking a renaissance of individuality- authors reply to the comment of Trino and Laura Baptista.

Schizophr Res

September 2024

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; German Centre for Mental Health (DZPG), partner site Mannheim, Germany. Electronic address:

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Is depression a global brain disorder with topographic dynamic reorganization?

Transl Psychiatry

July 2024

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Major depressive disorder (MDD) is characterized by a multitude of psychopathological symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal mechanisms underlying such co-occurrence of psychopathological symptoms remain yet unclear. Rather than linking and localizing single psychopathological symptoms to specific regions or networks, this perspective proposes a more global and dynamic topographic approach.

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Weak grip strength among persons with multiple sclerosis having minimal disability is not related to agility or integrity of the corticospinal tract.

Mult Scler Relat Disord

August 2024

Faculty of Medicine, Recovery & Performance Laboratory, Memorial University of Newfoundland and Labrador, Room 400, L.A. Miller Center, 100 Forest Road, St. John's, St. John's, NL A1A 1E5, Canada. Electronic address:

Introduction: Mobility impairment is common in multiple sclerosis (MS); however, agility has received less attention. Agility requires strength and neuromuscular coordination to elicit controlled propulsive rapid whole-body movement. Grip strength is a common method to assess whole body force production, but also reflects neuromuscular integrity and global brain health.

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Global neural self-disturbance in schizophrenia: A systematic fMRI review.

Schizophr Res

July 2024

The Royal's Institute of Mental Health Research & University of Ottawa, Brain and Mind Research Institute, Centre for Neural Dynamics, Faculty of Medicine, University of Ottawa, 145 Carling Avenue, Rm. 6435, Ottawa, ON, K1Z 7K4, Canada.

There is a general consensus that schizophrenia (SZ) is characterized by major changes in the sense of self. Phenomenological studies suggest that these changes in the sense of self stem from a basic disturbance, hence the term 'basic self-disturbance'. While imaging studies demonstrate changes in various regions during self-focused tasks, the exact neural correlates of such basic self-disturbances remain unclear.

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