13 results match your criteria: "The Research Institute of Strategy for Prevention.[Affiliation]"
Association between alcohol intake and death from cardiovascular diseases and its subtypes stratified by dyslipidemia in Japanese men: 20-years follow-up of NIPPON DATA90.
Environ Health Prev Med
November 2024
Department of Preventive Medicine and Public Health, Keio University School of Medicine.
Background: The association between alcohol consumption and atherosclerotic cardiovascular disease (ASCVD) was controversial, and no previous studies have shown the impact of dyslipidemia on the association. We aimed to clarify the association between alcohol consumption and death from cardiovascular disease (CVD) and its subtypes and the impact of dyslipidemia on the association.
Methods: We conducted a 20-year cohort study to clarify the association between alcohol intake and death from CVD and its subtypes in 2,909 Japanese men.
Article Synopsis
- The study investigates whether metabolic syndrome (MetS) affects the risk of functional disability differently based on sex and age in older adults.
- A total of 11,083 participants aged 65 and older were analyzed, with findings indicating that MetS increased the risk of functional disability particularly in men and women aged 65 to 74 years.
- Components of MetS, such as glucose intolerance and high blood pressure, were found to be significant predictors of functional disability, highlighting the importance of health intervention starting from middle age to reduce future risks.
Article Synopsis
- * Researchers proposed using low-sodium and potassium-rich seasonings in a company cafeteria, analyzing meal contents to estimate the effects on sodium and potassium levels.
- * Implementing these low-Na/K seasonings, along with additional milk servings, led to a significant reduction in sodium intake and an increase in potassium intake, improving the overall Na/K ratio.
We aimed to evaluate the association between the milk consumption and incident stroke in a Japanese population, where milk consumption is lower than that of Western countries. In total, 14,121 participants (4253 men and 9868 women) aged 40-69 years, free from cardiovascular diseases (CVD) were prospectively followed for 10.7 years.
View Article and Find Full Text PDFUtility of urinary albumin excretion as an index for stratifying the residual cardiovascular risk in patients undergoing antihypertensive agents treatment.
J Hypertens
December 2021
Department of Internal Medicine.
Background: Patients treated with antihypertensive medication, even those with well controlled blood pressure (BP), are at higher risk for the development of atherosclerotic cardiovascular disease (ASCVD) in comparison to nonhypertensive individuals with optimal risk levels. We hypothesized that this residual risk could be stratified based on urinary albumin excretion (UAE).
Methods: A total of 13 082 middle-aged and older individuals with SBP/DBP of less than 160/100 mmHg and urinary albumin-to-creatinine ratios (UACRs) of less than 300 mg/g, and who were free from ASCVD events, were followed to investigate the incidence of ASCVD.
Slightly Elevated Serum Ionic Fluoride Levels Inhibit Insulin Secretion and Increase Glucose Levels in a General Japanese Population: a Cross-sectional Study.
Biol Trace Elem Res
August 2021
The Research Institute of Strategy for Prevention, Shinkawa 1-39 4F, Chuo-ku, Tokyo, 104-0033, Japan.
A cross-sectional study was performed to investigate the relationships between serum fluoride levels, glucose levels, and insulin secretion in a general population. A total of 330 healthy subjects (167 men; 163 women) aged between 40 and 69 years were examined. Lifestyle information was obtained using questionnaires.
View Article and Find Full Text PDFAdditional prognostic value of electrocardiographic left ventricular hypertrophy in traditional cardiovascular risk assessments in chronic kidney disease.
J Hypertens
June 2020
Department of Internal Medicine.
Background: Left ventricular hypertrophy (LVH) is a common predictor of the cardiovascular prognosis in chronic kidney disease (CKD). However, whether or not electrocardiography-derived LVH (ECG-LVH) has prognostic value in patients with various degrees of CKD and improves the cardiovascular risk stratification based on traditional risk factors remains unclear.
Methods: A total of 7206 participants at least 40 years of age who were free from cardiovascular events in a general population were followed for the incidence of cardiovascular events.
Prognostic Value of Electrocardiographic Left Ventricular Hypertrophy on Cardiovascular Risk in a Non-Hypertensive Community-Based Population.
Am J Hypertens
July 2018
Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Background: The appearance of left ventricular hypertrophy on 12-lead electrocardiography (ECG-LVH) has been clarified to be associated with the risk of incidence of cardiovascular events (CVEs) in hypertensive individuals and the general population, but not enough in non-hypertensive individuals.
Methods: A total of 4,927 non-hypertensive individuals ≥40 years of age who were free of CVE in the general population were followed for the incidence of CVE. ECG-LVH was defined according to criteria of the Sokolow-Lyon (SL) voltage, Cornell voltage (CV), or Cornell voltage product (CP).
Burden of high blood pressure as a contributing factor to stroke in the Japanese community-based diabetic population.
Hypertens Res
July 2018
Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Diabetes mellitus is characterized by alterations in blood glucose (BG) metabolism, and glycated hemoglobin (HbAc) has been widely used as a marker of the BG concentration. Diabetes often coexists with high blood pressure (BP). High BP and hyperglycemia are well-known risk factors of stroke.
View Article and Find Full Text PDFArticle Synopsis
- Research investigated how well cardiovascular biomarkers predict different types of strokes in the general population, focusing on B-type natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), and urinary albumin corrected by urinary creatinine (UACR).
- The study involved 13,575 participants and found that while UACR and hs-CRP had suboptimal predictive ability for ischemic strokes, BNP performed excellently at predicting cardioembolic strokes, with a strong area under the curve (AUC-ROC) value of 0.81.
- When BNP was combined with existing stroke risk factors or the JPHC score, its predictive ability significantly improved, highlighting its potential as a
Article Synopsis
- - The study analyzed the risks of stroke and heart failure related to atrial fibrillation (AF) among 23,731 Japanese individuals, comparing those with AF to those without.
- - It found that AF significantly increased the risk of stroke and heart failure in both middle-aged and elderly participants, with higher event rates per 1000 person-years compared to non-AF individuals.
- - The results suggest that AF poses a similar stroke risk as observed in Western countries, but a greater relative risk for heart failure compared to those populations.
Comparison between urine albumin-to-creatinine ratio and urine protein dipstick testing for prevalence and ability to predict the risk for chronic kidney disease in the general population (Iwate-KENCO study): a prospective community-based cohort study.
BMC Nephrol
May 2016
Division of Cardiology, Department of Internal Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan.
Article Synopsis
- This study investigated how well two methods—using eGFR combined with UACR versus eGFR combined with urine dipstick tests—identify chronic kidney disease (CKD) and predict cardiovascular risks in the Japanese population.
- A total of 22,975 participants were initially assessed, revealing a CKD prevalence of 9% with the dipstick testing method and 29% with the UACR method over a follow-up period of about 5.6 years.
- The results indicated that using UACR to classify CKD produced better risk prediction for cardiovascular events, particularly for those in higher risk grades, showing that this approach is more effective than dipstick testing.
Background: The relative and absolute risks of outcomes other than all-cause death (ACD) attributable to atrial fibrillation (AF) stratified age have not been sufficiently investigated.
Methods: A prospective study of 23,634 community dwellers aged 40 years or older without organic cardiovascular disease (AF=335, non-AF=23,299) was conducted. Multivariate-adjusted rates, rate ratios (RRs) and excess deaths (EDs) for ACD, cardiovascular death (CVD) and non-cardiovascular death (non-CVD), and sex- and age-adjusted RR and ED in middle-aged (40 to 69) and elderly (70 years or older) for ACD, CVD, non-CVD, sudden cardiac death (SCD), stroke-related death (Str-D), neoplasm-related death (NPD), and infection-related death (IFD) attributable to AF were estimated using Poisson regression.