7 results match your criteria: "The Reading Hospital of Tower Health[Affiliation]"
Publisher Correction: Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes.
Nat Commun
September 2022
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes.
Nat Commun
August 2022
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Article Synopsis
- Accurate classification of variants' pathogenicity is essential for both research and clinical applications, showing significant connections between rare variants and specific health traits in three monogenic diseases.* -
- Analysis of data from three large studies reveals that effect sizes linked to these health traits can effectively differentiate between pathogenic and non-pathogenic variants, with strong statistical significance (P < 0.001).* -
- The research suggests that using these quantitative endophenotypes can identify up to 35% of rare variants of uncertain significance as potentially pathogenic, thereby enhancing our understanding of disease susceptibility.*
Hormone therapy for postmenopausal osteoporosis management.
Climacteric
February 2022
Department of Obstetrics, Gynecology and Reproductive Sciences, UCSF, San Francisco, CA, USA.
Menopausal hormone therapy (MHT) has been used for prevention and treatment of postmenopausal osteoporosis for several decades. However, public concerns were raised over the safety of MHT after the initial report was published in 2002 by the Women's Health Initiative. We conducted a historical review on this subject, primarily focusing on level I evidence from randomized controlled trials, systematic reviews and meta-analyses, and summarized high-quality evidence on the efficacy and safety of MHT in management of postmenopausal osteoporosis.
View Article and Find Full Text PDFGynecologic Screening for Men in an OBGYN Resident Community Outreach Clinic: The Transgender Care Experience.
J Low Genit Tract Dis
October 2018
Department of ObGyn, The Reading Hospital of Tower Health, Reading, PA.
Objective: The aim of the study was to promote the importance of providing gynecologic screening for transgender men (TGM) who desire to keep their female organs.
Materials And Methods: In June 2015, the Women's Health Center (WHC) at Reading Hospital was approached to become a resource for transgender (TG) patients in our community. This also presented the opportunity to develop an educational program for OBGYN residents/providers in TG healthcare.
Depression may be a risk factor for coronary heart disease in midlife women <65 years: A 9-year prospective cohort study.
Int J Cardiol
November 2018
Department of ObGyn, The Reading Hospital of Tower Health, Reading, PA, United States; Internal Medicine, The Reading Hospital of Tower Health, Reading, PA, United States; Departments of ObGyn, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, United States; Internal Medicine, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, United States.
Objective: Depression has been suggested as a risk factor for coronary heart disease (CHD). However, whether the risk may be affected by age is unknown. We seek to assess the difference in long-term CHD risk between younger (<65) and older (≥65) women with depressive symptoms.
View Article and Find Full Text PDFEstrogen therapy for osteoporosis in the modern era.
Osteoporos Int
May 2018
Department of Obstetrics, Gynecology and Reproductive Sciences, UCSF, San Francisco, CA, USA.
Menopause predisposes women to osteoporosis due to declining estrogen levels. This results in a decrease in bone mineral density (BMD) and an increase in fractures. Osteoporotic fractures lead to substantial morbidity and mortality, and are considered one of the largest public health priorities by the World Health Organization (WHO).
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