3,032 results match your criteria: "The Prince Charles Hospital.[Affiliation]"

The "International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024" updates and replaces the "Listing Criteria for Heart Transplantation: International Society for Heart and Lung Transplantation Guidelines for the Care of Cardiac Transplant Candidates-2006" and the "2016 International Society for Heart Lung Transplantation Listing Criteria for Heart Transplantation: A 10-year Update." The document aims to provide tools to help integrate the numerous variables involved in evaluating patients for transplantation, emphasizing updating the collaborative treatment while waiting for a transplant. There have been significant practice-changing developments in the care of heart transplant recipients since the publication of the International Society for Heart and Lung Transplantation (ISHLT) guidelines in 2006 and the 10-year update in 2016.

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  • The study looks at how the location where doctors put tubes in the arteries for heart support affects brain health after surgery.
  • They compared three methods: using the aorta, subclavian/axillary arteries, and femoral artery to see which had the least brain problems.
  • Results showed that patients using the subclavian/axillary method had more major brain issues compared to the others, and also had more seizures after the surgery.
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A 'Direct to Psychology Insomnia' pathway was developed for implementation within a multidisciplinary sleep disorders service in a tertiary hospital in Brisbane, Australia. The project was informed by implementation science principles and methodology to re-design the model of care (MoC). A consensus group workshop using the Nominal Group Technique (NGT) with 12 multidisciplinary staff was undertaken to develop the new MoC.

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  • - The study focuses on veno-venous extracorporeal membrane oxygenation (VV-ECMO) for patients with severe respiratory failure, highlighting the significant impact of right ventricular injury (RVI) on patient outcomes amid the lack of a standard RVI definition and management strategies.
  • - An international panel of experts, using a Delphi process, identified key areas of uncertainty about RVI and formulated expert position statements, achieving consensus on 31 out of 35 statements regarding nomenclature, diagnostic approaches, and management strategies related to RVI in the context of VV-ECMO.
  • - While recommendations for RVI management were made, there was no consensus on specific strategies, such as RV-protective driving pressure thresholds
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Introduction: The GOAL Cluster Randomised Controlled Trial (NCT04538157) is now underway, investigating the impact of comprehensive geriatric assessment (CGA) for frail older people with chronic kidney disease (CKD). The primary outcome is the attainment of patient-identified goals at 3 months, assessed using the goal attainment scaling process. The protocol requires a dedicated process evaluation that will occur alongside the main trial, to investigate issues of implementation, mechanisms of impact and contextual factors that may influence intervention success.

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Background: Physiotherapy is recommended for bronchiectasis management, but there is disparity in evidence supporting its use. This is partly because of inconsistency and poor reporting of outcomes in available studies. A Core Outcome Set (COS) may improve trial consistency and decrease reporting bias.

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Background: Packed red blood cell (pRBC) transfusion is a relatively safe and mainstay treatment commonly used in cardiac surgical patients. However, there is limited evidence on clinical effects of transfusing blood nearing end-of shelf life that has undergone biochemical changes during storage.

Objective: To investigate evidence of associations between morbidity/mortality and transfusion of blood near end of shelf-life (> 35 days) in cardiac surgical patients.

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Epidemiology of hypophosphatemia in critical illness: A multicentre, retrospective cohort study.

Anaesth Crit Care Pain Med

October 2024

Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; Adult Intensive Care Services, the Prince Charles Hospital, Brisbane, Queensland, Australia; Intensive Care Unit, Caboolture Hospital, Caboolture, Queensland, Australia; Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, Australia.

Article Synopsis
  • Hypophosphatemia is frequently observed in critically ill patients admitted to Intensive Care Units (ICUs), with a study examining its prevalence and outcomes in Queensland, Australia between 2015 and 2021.
  • Out of 89,776 patients, 68,699 were included, and 34.2% experienced hypophosphatemia, typically identified on the second day of ICU stay and resolved within three days.
  • The severity of hypophosphatemia correlated with increased 90-day mortality rates, with moderate and severe cases showing significantly higher fatality risks compared to those without hypophosphatemia.
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The CSANZ/RANZCR Position Statement on Cardiac Magnetic Resonance Imaging (CMRI) is intended to support and foster the provision of quality, safe CMRI services in Australia and New Zealand. This document specifically pertains to CMRI in adults, as distinct from general vascular MRI or paediatric imaging, and provides certification and recertification requirements.

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Background: Internationally qualified nurses are highly sought after as a labour source due to continued shortages in the nursing profession in most developed countries. However, the lack of clear policies and procedures for nurses in the host country to use specialty nursing skills can result in the underutilisation of their expertise.

Objectives: To review the registration processes of internationally qualified nurses in 20 developed countries, with a focus on the transferability of specialised skills gained overseas.

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Background: It is unclear if immunomodulation via cytokine adsorption (CA) to reduce perioperative inflammatory cascade in cardiothoracic transplants is associated with better outcomes.

Objective: This pilot study aims to assess the clinical outcomes of intraoperative CA in heart/lung transplantation.

Methods: From July to October 2020, intraoperative CA was instituted in 11 patients who underwent heart/lung transplantation.

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Purpose: The Royal Australasian College of Physicians (RACP) oversees physician training across Australia and Aotearoa New Zealand. Success in a written examination and clinical skills assessment (known as the clinical examination) at the mid-point of training is a requirement to progress from basic to advanced training. The clinical examination had evolved over many years without a review process.

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Mycobacterium abscessus treatment outcomes in cystic fibrosis: A single centre experience.

J Cyst Fibros

July 2024

Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK; Cambridge Centre for Lung Infection (CCLI), Royal Papworth Hospital, Cambridge, UK; Heart Lung Research Institute, University of Cambridge, Cambridge, UK.

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Refractory end-stage pulmonary failure may benefit from extracorporeal life support (ECLS) as a bridge to lung transplantation. Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) has been recommended for patients who have failed conventional medical therapy and mechanical ventilation. Veno-arterial (VA) ECMO may be used in patients with acute right ventricular (RV) failure, haemodynamic instability, or refractory respiratory failure.

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Mitral valve prolapse (MVP) affects 2-3% of the general population, and despite its benign prognosis overall, it is associated with sudden death in a small subset of patients. The term "arrhythmic MVP syndrome" (AMVPS) refers to the presence of frequent or complex ventricular arrhythmias, commonly reported in female patients with a stereotypical phenotype including bileaflet myxomatous disease, ECG repolarisation abnormalities in inferior leads, mitral annular disjunction, and significant fibrosis in the inferolateral LV and papillary muscles. Modern imaging technologies have led to the identification of new risk factors that have been implemented in recent risk stratification guidelines; however, screening for patients with MVP who are at risk of sudden cardiac death (SCD) remains challenging.

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Background: The LATE score (LATE: Left Atrial reservoir strain (LASr), Tricuspid regurgitation maximum velocity (TR Vmax), and E/e' average) is a novel framework for echocardiographic assessment of left ventricular filling pressure (LVFP). LATE = 0 indicates normal LVFP. LATE = 1 indicates resting LVFP is borderline elevated, and the patient may be at risk of pathological elevation of LVFP during exertion.

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Rehabilitation after surgery for hip fracture - the impact of prompt, frequent and mobilisation-focused physiotherapy on discharge outcomes: an observational cohort study.

BMC Geriatr

July 2024

School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Susan Wakil Health Building, Level 7 D18Western Avenue NSW 2006, Camperdown, Australia.

Purpose: To determine the relationship between three postoperative physiotherapy activities (time to first postoperative walk, activity on the day after surgery, and physiotherapy frequency), and the outcomes of hospital length of stay (LOS) and discharge destination after hip fracture.

Methods: A cohort study was conducted on 437 hip fracture surgery patients aged ≥ 50 years across 36 participating hospitals from the Australian and New Zealand Hip Fracture Registry Acute Rehabilitation Sprint Audit during June 2022. Study outcomes included hospital LOS and discharge destination.

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ST Elevation Myocardial Infarction Complicated by Cardiogenic Shock: Systematic Review of Survival Predictors.

Am J Med Open

December 2023

St Vincent's Hospital Clinical School, The University of New South Wales, Sydney Australia; Department of Cardiology, Royal North Shore Hospital, Sydney, Australia; The CardioVascular Center, Tufts, Boston Mass.

Background: Cardiogenic shock complicating acute myocardial infarction is associated with reduced survival despite advancements in the treatment of acute coronary syndromes. Characterizing predictors of morbidity and mortality in this setting is crucial to improving risk stratification and management. Notwithstanding, the interplay of factors determining survival in this condition remains poorly studied.

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  • The JAVELIN Lung 101 trial tested avelumab, an immune checkpoint inhibitor, alongside lorlatinib or crizotinib (tyrosine kinase inhibitors) in advanced non-small cell lung cancer (NSCLC).
  • The study aimed to determine the maximum tolerated dose (MTD) and evaluate the treatment's effectiveness based on patient response rates, focusing on dose-limiting toxicities (DLTs).
  • Results showed that avelumab with lorlatinib was manageable with a response rate of 52%, while avelumab with crizotinib was less feasible, with a lower response rate of 25% and high DLT incidence.
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Protocol for high-plex, whole-slide imaging of human formalin-fixed paraffin-embedded tissue using PhenoCycler-Fusion.

STAR Protoc

September 2024

Queensland Spatial Biology Centre, Wesley Research Institute, Level 8 East Wing, The Wesley Hospital, Auchenflower, QLD 4066, Australia; Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia. Electronic address:

Article Synopsis
  • Single-cell spatial analysis of proteins is crucial for gaining insights into biology, especially in cancer research.
  • The text outlines an automated protocol for multi-slide immunofluorescence staining and imaging of human head and neck cancer samples using PhenoCycler-Fusion 2.0 technology.
  • It includes detailed steps for tissue preparation, staining with immunophenotyping markers, and subsequent analysis procedures, with more specifics available in a referenced study by Jhaveri et al.
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Cluster analysis of blood biomarkers to identify molecular patterns in pulmonary fibrosis: assessment of a multicentre, prospective, observational cohort with independent validation.

Lancet Respir Med

September 2024

NIHR Imperial Biomedical Respiratory Research Centre, National Heart and Lung Institute, Imperial College London, London, UK; Interstitial Lung Disease Unit, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Article Synopsis
  • - The study investigates pulmonary fibrosis, a condition where lung tissue becomes damaged, by classifying patients based on blood biomarkers to identify different disease types, or endotypes.
  • - Researchers used data from the PROFILE study, involving a group of UK patients, to perform cluster analysis and measure 13 specific blood biomarkers related to lung tissue health.
  • - The analysis revealed three distinct patient clusters that correlate with different biomarker levels, providing insights into disease patterns and their associations with mortality and lung function decline.
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  • The study evaluates the prevalence and management of delirium in Italian hospitals, revealing that only 43.1% of participating wards demonstrated high delirium literacy.
  • Approximately 10% of hospitalized patients were reported to have delirium, with higher prevalence in high literacy wards, which also showed better management practices.
  • Key issues identified include inadequate management, barriers to implementing effective strategies, and a lack of training, underscoring the need for improved awareness and evidence-based practices in delirium care.
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Background: Pulmonary hypertension (PH) is a debilitating condition characterized by elevated pulmonary arterial pressure and progressive vascular remodelling, leading to exercise intolerance. The progression of PAH is regulated at a cellular and molecular level which influences various physiological processes. Exercise plays an important role in improving function in PH.

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Cardiac magnetic resonance imaging (CMR) is the gold-standard non-invasive method of assessing cardiac structure and function, including tissue characterisation. In systemic sclerosis (SSc), heart involvement (SHI) is a leading cause of mortality yet remains poorly understood. SHI is underestimated by conventional echocardiography, and CMR provides an important opportunity to better identify and quantify subtle myocardial changes including oedema and fibrosis.

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Purpose: Community-based residential mental health rehabilitation units for people experiencing severe and persistent mental illness are increasingly available in Australia. Research completed 20 years ago suggested that people leaving these services often experienced impoverished social lives and other challenges in the community. It is unclear whether contemporary consumers experience similar difficulties.

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