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744 results match your criteria: "The Perelman School of Medicine at the University of Pennsylvania[Affiliation]"
J Clin Oncol
December 2024
Ti-Cheng Chang, PhD, Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN; Wenan Chen, PhD, Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, Division of Computational Biology, Mayo Clinic, Rochester, MN; Chunxu Qu, PhD, Department of Pathology, St Jude Children's Research Hospital, Memphis, TN; Zhongshan Cheng, PhD, Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN; Abdelrahman Elsayed, PhD and Stanley B. Pounds, PhD, Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN; Mary Shago, PhD, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Karen R. Rabin, MD, PhD, Department of Pediatrics, Baylor College of Medicine, Houston, TX; Elizabeth A. Raetz, MD, Department of Pediatrics, Perlmutter Cancer Center, NYU Langone Hospital, New York, NY; Meenakshi Devidas, PhD, Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN; Cheng Cheng, PhD, Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN; Anne Angiolillo, MD, Children's National Medical Center, Washington, DC; Pradyuamma Baviskar, PhD, Department of Pathology, St Jude Children's Research Hospital, Memphis, TN; Michael Borowitz, MD, Department of Pathology, Johns Hopkins University, Baltimore, MD; Michael J. Burke, MD, Division of Pediatric Hematology-Oncology, Medical College of Wisconsin, Milwaukee, WI; Andrew Carroll, PhD, Department of Genetics, University of Alabama at Birmingham, Birmingham, AL; William L. Carroll, MD, Department of Pediatrics, Perlmutter Cancer Center, NYU Langone Hospital, New York, NY; I-Ming Chen, DVM and Richard Harvey, PhD, Department of Pathology, University of New Mexico, Albuquerque, NM; Nyla Heerema, PhD, The Ohio State University, Columbus, OH; Ilaria Iacobucci, PhD, Department of Pathology, St Jude Children's Research Hospital, Memphis, TN; Jeremy R. Wang, PhD, Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; Sima Jeha, MD, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN; Eric Larsen, MD, Department of Pediatrics, Maine Children's Cancer Program, Scarborough, ME; Leonard Mattano, MD, HARP Pharma Consulting, Mystic, CT; Kelly Maloney, MD, Department of Pediatrics and Children's Hospital Colorado, University of Colorado, Aurora, CO; Ching-Hon Pui, MD, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN; Nilsa C. Ramirez, MD, Institute for Genomic Medicine and Biopathology Center, Nationwide Children's Hospital, Departments of Pathology and Pediatrics, Ohio State University, Columbus, OH; Wanda Salzer, MD, Uniformed Services University, School of Medicine, Bethesda, MD; Cheryl Willman, MD, Department of Laboratory Medicine and Pathology and Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN; Naomi Winick, MD, Department of Pediatric Hematology Oncology and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX; Brent Wood, MD, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA; Stephen P. Hunger, MD, Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Gang Wu, PhD, Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, Department of Pathology, St Jude Children's Research Hospital, Memphis, TN; Charles G. Mullighan, MBBS, MD, Department of Pathology, St Jude Children's Research Hospital, Memphis, TN; and Mignon L. Loh, MD, Department of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children's Hospital, University of Washington, Seattle, WA.
bioRxiv
December 2024
Department of Radiology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Deep learning-based cortical surface reconstruction (CSR) methods heavily rely on pseudo ground truth (pGT) generated by conventional CSR pipelines as supervision, leading to dataset-specific challenges and lengthy training data preparation. We propose a new approach for reconstructing multiple cortical surfaces using from brain MRI ribbon segmentations. Our approach initializes a midthickness surface and then deforms it inward and outward to form the inner (white matter) and outer (pial) cortical surfaces, respectively, by jointly learning diffeomorphic flows to align the surfaces with the boundaries of the cortical ribbon segmentation maps.
View Article and Find Full Text PDFCells
December 2024
Institute for Biomedical Technologies, National Research Council, 56124 Pisa, Italy.
Cornelia de Lange syndrome (CdLS) is a rare, dominantly inherited multisystem developmental disorder. Pathogenic variants in genes encoding the structural subunits and regulatory proteins of the cohesin complex (, , , , and ) are the primary contributors to the pathogenesis of CdLS. Pathogenic variations in these genes disrupt normal cohesin function, leading to the syndrome's diverse and complex clinical presentation.
View Article and Find Full Text PDFPaediatr Respir Rev
October 2024
Division of Pulmonology, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, United States.
The chest and spine deformity in neuromuscular disease (NMDz) can impact respiratory mechanics and pulmonary function by changing the orientation of the muscles and joints of the respiratory system and placing them in a mechanically unfavorable position. This increases mechanical load on weak respiratory muscles and eventually can cause respiratory failure. Therefore, chest and spine deformity in NMDz will both lead to increased respiratory "load" and decreased respiratory muscle "pump", an exceptionally bad combination.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Surgery, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Our group has developed an extra-uterine environment for newborn development (EXTEND) using an ovine model, that aims to mimic the womb to improve short and long-term health outcomes associated with prematurity. This study's objective was to determine the histologic and transcriptomic consequences of EXTEND on the brain. Histology and RNA-sequencing was conducted on brain tissue from three cohorts of lambs: control pre-term (106-107 days), control late pre-term (127 days), and EXTEND lambs who were born pre-term and supported on EXTEND until late pre-term age (125-128 days).
View Article and Find Full Text PDFJ Perinatol
November 2024
Department of Pediatrics, Université de Montréal, Montréal, CA, Canada.
When a baby is born premature, a landscape of potential problems replaces an imagined future. Outcomes become the measures of success. Researchers are recognizing that we need the direct input of parents to select meaningful outcomes.
View Article and Find Full Text PDFAntimicrob Agents Chemother
December 2024
Children's Hospital of Orange County, Orange, and University of California, Irvine, California, USA.
Pharmacol Ther
December 2024
RTI International, Research Triangle Park, NC, United States of America.
Programs for preclinical testing of targeted cancer agents in murine models of childhood cancers have been supported by the National Cancer Institute (NCI) since 2004. These programs were established to work collaboratively with industry partners to address the paucity of targeted agents for pediatric cancers compared with the large number of agents developed and approved for malignancies primarily affecting adults. The distinctive biology of pediatric cancers and the relatively small numbers of pediatric cancer patients are major challenges for pediatric oncology drug development.
View Article and Find Full Text PDFJ Am Coll Radiol
October 2024
Chief Medical Officer, Radiology Leadership Institute, American College of Radiology; Professor and Vice Chair of Radiology at University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Pediatr Res
October 2024
Department of Pediatrics, UChicago Medicine at the University of Chicago, Chicago, US.
The pediatric subspecialty workforce is challenged by shortages and geographic maldistribution of subspecialists. We invited leaders in pediatrics to discuss how the field's vitality and survival can be secured. These leaders presented their own opinions and not the opinion of the society or organization that they are presenting.
View Article and Find Full Text PDFAm J Nurs
November 2024
Mollie Hobensack is a clinical program manager of quality and informatics at the Icahn School of Medicine at the Mount Sinai Health System in New York City. Eleanor Turi is a postdoctoral fellow at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia. Julie Sochalski is an associate professor of nursing and associate dean for academic programs at the University of Pennsylvania School of Nursing. Eleanor Turi is funded by National Institute of Mental Health grant T32MH109433 and the National Clinician Scholars Program. The views expressed here are those of the authors and do not reflect the position or policy of any of the authors' institutions. Contact author: Mollie Hobensack, The authors have disclosed no potential conflicts of interest, financial or otherwise.
Research and clinical practice can inform and improve each other.
View Article and Find Full Text PDFEpilepsy Behav Rep
September 2024
The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, the United States of America.
Developmental epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS) is an epilepsy syndrome of childhood characterized by developmental delay or regression with significant abnormal epileptiform activity during sleep. In some cases, DEE-SWAS with an identified focal lesion is treated with surgical resection. The authors report an unusual case of focal DEE-SWAS that was successfully treated via transorbital resection with intraoperative electrocorticography (iECoG).
View Article and Find Full Text PDFChest
October 2024
Department of Medicine, Palliative and Advanced Illness Research (PAIR Center), Pulmonary, Allergy and Critical Care Division, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:
J Clin Endocrinol Metab
October 2024
Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Sci Rep
October 2024
Cancer and Blood Disease Institutes, Children's Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Blvd #57, Los Angeles, CA, 90027, USA.
Pediatr Crit Care Med
October 2024
Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia. Philadelphia, PA.
Circulation
October 2024
Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy (N.M., C.F., I.O.).
J Am Acad Orthop Surg
September 2024
From the Medical University of South Carolina, Charleston, SC (Silvestre), the Washington University School of Medicine, St Louis, MO (Tippabhatla and Hosseinzadeh), the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (Kelly), and the Brigham and Women's Hospital, Boston, MA (Kang).
Introduction: Previous research has highlighted conflicts of interest stemming from industry funding and education of orthopaedic surgeons. This study sought to define the nature and magnitude of industry payments to orthopaedic surgery fellowship program directors (FPDs) in the United States.
Methods: This was a retrospective cohort study of orthopaedic surgery FPDs during 2021.
Epilepsy Curr
May 2024
Division of Neurology, Department of Pediatrics, Epilepsy NeuroGenetics Initiative, The Children's Hospital of Philadelphia Department of Neurology, Department of Neuroscience, The Perelman School of Medicine at The University of Pennsylvania.
J Clin Endocrinol Metab
September 2024
Department of Pediatrics, Golisano Children's Hospital, The University of Rochester School of Medicine and Dentistry.
Context: The adverse skeletal effects of type 1 diabetes (T1D) include deficient bone accrual and lifelong increased fracture risk. The contributors to impaired bone accrual in people with T1D are incompletely understood.
Objective: To determine if urinary calcium excretion is associated with impaired bone accrual in youth with T1D and to characterize the contribution of glycemic control and markers of bone mineral metabolism to urinary calcium excretion.
Epilepsy Curr
January 2024
Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia Epilepsy NeuroGenetics Initiative, The Children's Hospital of Philadelphia Department of Neurology, The Perelman School of Medicine at The University of Pennsylvania Department of Neuroscience, The Perelman School of Medicine at The University of Pennsylvania.
HGG Adv
October 2024
Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:
Haploinsufficiency of JAG1 is the primary cause of Alagille syndrome (ALGS), a rare, multisystem disorder. The identification of JAG1 intronic variants outside of the canonical splice region as well as missense variants, both of which lead to uncertain associations with disease, confuses diagnostics. Strategies to determine whether these variants affect splicing include the study of patient RNA or minigene constructs, which are not always available or can be laborious to design, as well as the utilization of computational splice prediction tools.
View Article and Find Full Text PDFPract Radiat Oncol
November 2024
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Purpose: Increasing concern that brainstem toxicity incidence after proton radiation therapy might be higher than with photons led to a 2014 University of Florida (UF) landmark paper identifying its risk factors and proposing more conservative dose constraints. We evaluated how practice patterns changed among the Pediatric Proton/Photon Consortium Registry (PPCR).
Material And Methods: This prospective multicenter cohort study gathered data from patients under the age of 22 years enrolled on the PPCR, treated between 2002 and 2019 for primary posterior fossa brain tumors.
J Clin Oncol
October 2024
Department of Pediatrics and the Ben Towne Center for Childhood Cancer Research, Seattle Children's Hospital, University of Washington, Seattle, WA.