590 results match your criteria: "The People’s Hospital of Liaoning Province[Affiliation]"

Article Synopsis
  • Previous studies showed that neuroprotective agents have limited effectiveness for treating acute ischemic stroke (AIS), but Tongxinluo, originating from traditional Chinese medicine, has demonstrated neuroprotective and anti-inflammatory effects.
  • The study aimed to evaluate the efficacy and safety of Tongxinluo in AIS patients through a multicenter, double-blind, randomized clinical trial involving 2007 participants across 50 hospitals in China.
  • Results indicated that patients treated with Tongxinluo had significantly better functional outcomes at 90 days compared to the control group, highlighting its potential as a beneficial treatment for AIS.
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CUL1 exacerbates glucocorticoid-induced osteoporosis by enhancing ASAP1 ubiquitination.

Hormones (Athens)

September 2024

Department of Orthopaedics, The People's Hospital of Liaoning Province, 33 Wenyi Road, Shenyang, 110016, Liaoning, People's Republic of China.

Article Synopsis
  • Glucocorticoid-induced osteoporosis is a significant secondary cause of osteoporosis, and this study investigates the role of elevated Cullin-1 (CUL1) in this condition.
  • Using a mouse model, researchers injected dexamethasone to induce osteoporosis and examined bone injury, cell death, and bone formation through various techniques.
  • The findings revealed that silencing CUL1 can reduce osteoporosis effects by inhibiting its promotion of ASAP1 degradation, which negatively impacts bone formation and leads to increased cell death.
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Sonodynamic inactivation of gram-negative and gram-positive bacteria in the presence of phenothiazine compounds toluidine blue and azurin A.

Biochim Biophys Acta Gen Subj

November 2024

School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, PR China; Shenyang Key Laboratory for Causes and Drug Discovery of Chronic Diesases, Liaoning University, Shenyang 110036, China. Electronic address:

Background: Sonodynamic antimicrobial chemotherapy (SACT) is an effective antimicrobial treatment that can avoid the production of drug-resistant bacteria. Design and development of new high-efficiency sonosensitizers play a key role in the practical application of SACT.

Methods: The bacteriostatic effects of two phenothiazine compounds, toluidine blue (TB) and azure A (AA) combined with ultrasonic (US) on Escherichia coli (E.

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Article Synopsis
  • BPA (Bisphenol A) is a chemical that disrupts hormones and can cause health problems, especially regarding reproduction and development.
  • In a study, rats were given BPA for 60 days, and scientists checked the health of their organs, gut bacteria, and chemicals in their body.
  • The results showed that BPA harmed the liver and heart, changed gut bacteria make-up, and decreased important fatty acids in the rats, indicating it can be harmful to their health.
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Background: Prior research has demonstrated a discrepancy between pathologic and clinical staging in individuals with muscle-invasive bladder cancer (MIBC) following neoadjuvant chemotherapy (NAC). These findings were the major reasons for the under-usage of the bladder preservation strategy. Hence, we aim to explore the reliable markers in identifying pathological complete response (ypCR) status in MIBC patients who achieved clinical complete response (cCR) after NAC.

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Cognitive dysfunction caused by chronic cerebral hypoperfusion (CCH) is the leading cause of vascular dementia. Therefore, it is necessary to explore the mechanism that causes cerebral injury and find an effective therapy. Bone marrow mononuclear cells (BMMNCs) were extracted to detect the activity by CCK-8 kit and verify the transfection efficiency using reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR).

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Background: As one of the most common cancer, colorectal cancer (CRC) is with high morbidity and mortality. Peritoneal metastasis (PM) is a fatal state of CRC, and few patients may benefit from traditional therapies. There is a complex interaction between PM and immune cell infiltration.

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Application of artificial intelligence in the diagnosis and treatment of urinary tumors.

Front Oncol

August 2024

Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

Diagnosis and treatment of urological tumors, relying on auxiliary data such as medical imaging, while incorporating individual patient characteristics into treatment selection, has long been a key challenge in clinical medicine. Traditionally, clinicians used extensive experience for decision-making, but recent artificial intelligence (AI) advancements offer new solutions. Machine learning (ML) and deep learning (DL), notably convolutional neural networks (CNNs) in medical image recognition, enable precise tumor diagnosis and treatment.

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Article Synopsis
  • Previous studies hint at connections between the TERT gene, shorter telomere length in white blood cells, and cerebrovascular disease, but the specific links haven't been confirmed.
  • Researchers analyzed TERT gene variations in 307 cerebrovascular disease patients and 320 healthy individuals, using genetic models to assess the relationship between these variations and the disease.
  • Results showed two gene variations significantly associated with the disease, and further analysis suggested that shorter telomeres could be causally linked to a higher risk of cerebrovascular disease.
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Echocardiography is a key tool for the diagnosis of cardiac diseases, and accurate left ventricular (LV) segmentation in echocardiographic videos is crucial for the assessment of cardiac function. However, since semantic segmentation of video needs to take into account the temporal correlation between frames, this makes the task very challenging. This article introduces an innovative method that incorporates a modified mixed attention mechanism into the SegFormer architecture, enabling it to effectively grasp the temporal correlation present in video data.

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DECNet: Left Atrial Pulmonary Vein Class Imbalance Classification Network.

J Imaging Inform Med

August 2024

School of Computer, Shenyang Aerospace University, Daoyi South Street, 110135, ShenYan, Liaoning Province, China.

In clinical practice, the anatomical classification of pulmonary veins plays a crucial role in the preoperative assessment of atrial fibrillation radiofrequency ablation surgery. Accurate classification of pulmonary vein anatomy assists physicians in selecting appropriate mapping electrodes and avoids causing pulmonary arterial hypertension. Due to the diverse and subtly different anatomical classifications of pulmonary veins, as well as the imbalance in data distribution, deep learning models often exhibit poor expression capability in extracting deep features, leading to misjudgments and affecting classification accuracy.

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Introduction: Previous studies in different populations have shown that vitamin D supplementation may reduce depression levels. In adolescents, vitamin D deficiency has been identified as a factor contributing to the onset of depression. This study aimed to establish a model of adolescent depression in mice by using the scientific unpredictable chronic mild stress (UCMS) model and to preliminarily evaluate the effect of vitamin D on the occurrence and development of depression and whether it is related to the protein expression of the BDNF pathway.

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Predictive Accuracy Analysis of a Novel Robotic-Assisted System for Total Knee Arthroplasty:A Prospective Observational Study.

Ther Clin Risk Manag

August 2024

Department of Sports Medicine and Joint Surgery, The People's Hospital of Liaoning Province, The People's Hospital of China Medical University, Shenyang, 110000, People's Republic of China.

Background: Robotic-assisted total knee arthroplasty (RATKA) has been reported to enhance operative decision-making. The purpose of this study was intended to assess the predictive accuracy of bone cuts, lower limb alignment, and component size of a novel system for RATKA preoperatively and intraoperatively.

Methods: Preoperatively planned bone cuts, limb alignment, and component size were projected using a reconstructed 3D model.

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Background: Clinical events such as angina pectoris, acute coronary syndrome, and sudden death caused by myocardial bridge (MB) have attracted increasing attention. It is still a challenge to diagnose whether MB can cause the symptoms of patients with MB. For most MB patients, medication remains the primary treatment.

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Brain macrophage senescence in glioma.

Semin Cancer Biol

September 2024

Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China. Electronic address:

Gliomas are a diverse group of primary central nervous system neoplasms with no curative therapies available. Brain macrophages comprise microglia in the brain parenchyma, border-associated macrophages in the meningeal-choroid plexus-perivascular space and monocyte-derived macrophages infiltrating the brain. With the great improvement of our recognition of brain macrophages, diverse macrophage populations have been found in the context of glioma, which exhibit functional and phenotypic heterogeneity.

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Aim: To evaluate the efficacy and safety of insulin glargine 300 U/mL (Gla-300) in people with suboptimally controlled type 2 diabetes (T2D) in China.

Methods: INITIATION (NCT05002933) was a prospective, interventional, multicentre, single-arm, phase IV study conducted in China. Individuals with suboptimally controlled T2D who were insulin naïve or switching from another basal insulin (insulin experienced) were included.

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TransDiffSeg: Transformer-Based Conditional Diffusion Segmentation Model for Abdominal Multi-Objective.

J Imaging Inform Med

July 2024

School of Computer, Shenyang Aerospace University, Daoyi South Street, ShenYang, 110135, Liaoning Province, China.

In the domain of medical image segmentation, traditional diffusion probabilistic models are hindered by local inductive biases stemming from convolutional operations, constraining their ability to model long-term dependencies and leading to inaccurate mask generation. Conversely, Transformer offers a remedy by obviating the local inductive biases inherent in convolutional operations, thereby enhancing segmentation precision. Currently, the integration of Transformer and convolution operations mainly occurs in two forms: nesting and stacking.

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Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection.

J Adv Res

July 2024

School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address:

Introduction: Insulin resistance (IR) is associated with multiple pathological features. Although p53- or TRIB3-orchestrated IR is extensively studied in adipose tissue and liver, the role of p53-TRIB3 axis in myocardial IR remains unknown, and more importantly target-directed therapies of myocardial IR are missing.

Objectives: Considering the beneficial effects of sulforaphane (SFN) on cardiovascular health, it is of particular interest to explore whether SFN protects against myocardial IR with a focus on the regulatory role of p53-TRIB3 axis.

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Background: Muscular strength has been linked to increased risk of cardiovascular disease in the community population. The aim of this systematic review and meta-analysis is to evaluate the association between weak handgrip strength (HGS) and mortality risk in patients with coronary artery disease (CAD).

Methods: To carry out the meta-analysis, an extensive search was conducted on databases such as PubMed, Embase, Web of Science, Cochrane Library, Wanfang, and CNKI to identify observational studies with longitudinal follow-up.

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N6-methyladenosine (m6A) methylation is a vital epigenetic mechanism associated with drug addiction. However, the relationship between m6A modification and oxycodone rewarding is less well explored. Based on an open field test, the present study evaluated oxycodone rewarding using chromatin immunoprecipitation PCR, immunofluorescence, and RNA sequencing.

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Rationale And Objectives: This study aims to predict intermediate to high-risk prostate cancer (PCa) prognosis based on 18-fluoro-2-deoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT) radiomics. Additionally, subgroup analysis will be performed on the androgen deprivation therapy (ADT) group and the metastatic PCa group.

Materials And Methods: In the retrospective analysis of 104 intermediate to high-risk PCa patients who underwent F-FDG PET/CT prior to treatment.

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Background: Disorders of consciousness (DoC) represent a spectrum of neurological conditions that pose significant treatment challenges. Percutaneous short-term spinal cord stimulation (SCS) has emerged as a promising experimental diagnostic treatment to assess and potentially improve consciousness levels. However, the effectiveness of this intervention is frequently compromised by the shift of electrodes, particularly in the cervical region, which can negatively affect therapeutic outcomes.

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Background: The plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and coronary slow flow phenomenon (CSFP) remains unclear.

Methods: A total of 1328 individuals with chronic coronary syndrome (CCS) receiving coronary angiography (CAG) and found no obvious obstructive stenosis (< 40%) were included in this study.

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