Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine.

Feline herpesvirus 1 (FHV-1) is an important pathogen causing infectious rhinotracheitis in felids, mainly infecting the upper respiratory tract and conjunctiva. Multiple vaccines are available to prevent FHV-1 infection, and the antibody levels are always used to evaluate their effectiveness. However, the cellular immunity response following immunization in cats remains unclear.

Integrated omics profiling of individual variations in intestinal damage to the soybean allergen in piglets.

Introduction: A small number of soybean allergens [including Glycinin (11S) and β-Conglycinin (7S)] in the commercially available corn-soybean meal diet can still cause allergy in some weaned piglets, which may be the result of the interaction of genetic, and nutrition, but the specific mechanism is still unclear.

Methods: In this study, 20 allergic piglets and 20 non-allergic piglets were selected from 92 weaned piglets by skin sensitization tests, which were used to examine the whole sequence genome. The indicators related to humoral and cellular immunity, transcriptomics, and metabolomics analysis were determined by randomly selecting 5 boars in the allergic group and non-allergic group and then performing a validation .

Effects of exogenous insulin supplementation on lipid metabolism in peripartum obese dairy cows.

Cows with high body condition scores experience more severe negative energy balance (NEB) and undergo mobilization of more body fat during the peripartum period, leading to more production of nonesterified fatty acids (NEFA) and -hydroxybutyric acid (BHBA). Postpartum insulin secretion is lower, and insulin resistance is stronger in obese cows. Exogenous insulin supplementation has been hypothesized as a key approach for regulating NEFA in these cows.

Advancing veterinary vaccines design through trained immunity insights.

Trained immunity, characterized by long-term functional reprogramming of innate immune cells, offers promising new directions for veterinary vaccine development. This perspective examines how trained immunity can be integrated into veterinary vaccine design through metabolic reprogramming and epigenetic modifications. We analyze key molecular mechanisms, including the shift to aerobic glycolysis and sustained epigenetic changes, that enable enhanced immune responses.

The impact of physical exercise on primary school teachers' professional ethics: the mediating role of self-control.

Background: Physical exercise has been shown to positively impact psychological and behavioral outcomes, yet its influence on professional ethics in educators remains underexplored. Understanding the mechanisms underlying this relationship is essential for developing interventions to promote ethical behavior in educational contexts.

Objectives: This study aims to investigate the relationship between physical exercise and professional ethics among elementary school teachers, with a specific focus on the mediating role of self-control.

Transforming students' green behavior through environmental education: the impact of institutional practices and policies.

Environmental education is crucial for achieving ecological sustainability goals and transforming human behavior to promote responsible consumption. Higher education institutions play a fundamental role in transforming societies aimed at a more sustainable future through the dissemination of environmental education to millions of young people worldwide. Therefore, this study aimed to measure the role of environmental education in transforming students' green behavior (SGB), along with other higher education institutional factors such as green campus initiatives (GCI), institutional ecosystem (IEC), institutional sustainability system (ISS), and institutional support system (ISP) through students' green intentions (SGI).

Improving sensory integration in Chinese children with moderate sensory integration challenges through engaging basketball training.

Objective: This study aimed to evaluate the effectiveness of combining basketball training with a traditional sensory integration therapy (SIT) vs. a SIT alone in enhancing sensory integration capability among Chinese children diagnosed with mild challenges in sensory integration and sensory processing (CSISP).

Methods: This study comprised a Control group and an Experimental group, both undergoing a 10-week intervention (4 sessions/week, 45 min/session).

Effects of music training on executive functions in preschool children aged 3-6 years: systematic review and meta-analysis.

Background: Executive functions is a crucial ability in the early development of preschool children. While numerous studies have found that music training has a favorable effect on children's executive functions, there is a lack of a consistent perspective on this topic, particularly with regard to the dose-response relationship.

Methods: Systematic searches were conducted of Web of Science, PubMed, Scopus, and China National Knowledge Infrastructure.

Re-discover student engagement from the perspective of definition and influencing factors.

In recent, the topic of student engagement has received a great deal of academic attention. However, there are numerous definitions of student engagement. Will this lead to inaccuracies and ambiguities in future definitions of student engagement? Therefore, it is important to have a common understanding of student engagement.

Peer rejection and internet gaming disorder: the mediating role of relative deprivation and the moderating role of grit.

Background: Internet Gaming Disorder (IGD) is a new behavioral addiction. A large number of empirical studies have shown that Internet Gaming Disorder has a high level of comorbidity with other diseases, including depression, anxiety, obesity, internalizing and externalizing behavioral problems, however, little is known about the mediating and moderating mechanisms underlying this relation. The current study adopted a three-time longitudinal study investing the mediating effect of relative deprivation on the association between peer rejection and IGD, and whether this mediating effect was moderated by the grit.

Effects of virtual reality motor games on motor skills in children with cerebral palsy: a systematic review and meta-analysis.

Background: Enhancing motor skills is crucial for the functional development of children with cerebral palsy. Virtual reality has emerged as a promising technology for rehabilitating these children.

Objective: The objective of this study was to systematically evaluate the effects of virtual reality motor games on the gross and fine motor skills of children with cerebral palsy.

The relationship between moral sensitivity and prosocial behavior in college students: the mediating roles of moral disengagement and reciprocity norms.

Introduction: This study examined the relationship between moral sensitivity and prosocial behavior, as well as the mediating role of moral disengagement and reciprocity norms.

Methods: Totally 567 college students completed Dispositional Moral Sensitivity Questionnaire, Moral Disengagement Scale for Chinese Students, Reciprocity Norm Scale, Prosocial Tendencies Measure for Adolescent.

Results: The results showed that, moral disengagement and reciprocity norms played multiple mediating roles between moral sensitivity and prosocial behavior.

Static and dynamic brain functional connectivity patterns in patients with unilateral moderate-to-severe asymptomatic carotid stenosis.

Background And Purpose: Asymptomatic carotid stenosis (ACS) is an independent risk factor for ischemic stroke and vascular cognitive impairment, affecting cognitive function across multiple domains. This study aimed to explore differences in static and dynamic intrinsic functional connectivity and temporal dynamics between patients with ACS and those without carotid stenosis.

Methods: We recruited 30 patients with unilateral moderate-to-severe (stenosis ≥ 50%) ACS and 30 demographically-matched healthy controls.

Cognitive trajectories and their relationships with education and diets among older adults: a network-based 10-year cohort study.

Objectives: Few studies have examined the underlying mechanisms of education, diets, and cognitive function in older adults. This study analyses the relationship between cognitive trajectories, education, and different dietary patterns in older adults from a network perspective, and further explores their longitudinal associations and mediation effects.

Methods: Data on cognitive trajectories were derived from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 2008 and 2018.

Clinical Outcomes of Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib and Tislelizumab for Treating Hepatocellular Carcinoma and Type IV Portal Vein Tumor Thrombus.

Purpose: To assess the activity and toxicity of hepatic arterial infusion chemotherapy (HAIC)+tislelizumab+lenvatinib (HAIC+tisle+len) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) type IV (Vp4 hCC) in a real-world context.

Methods: Fifty-five patients, with Vp4 hCC receiving HAIC+tisle+len therapy from April 2021 to December 2022, were analyzed retrospectively. Data on patient characteristics, adverse events (AEs), treatment, and survival were collected.

Design and Mechanism Study of 6c, a Novel Artesunate Derivatives, for Anti-Hepatocellular Carcinoma.

Objective: Artesunate can inhibit the proliferation of various tumor cells and has practical value in developing anti-tumor drugs. However, its biological activity against hepatocellular carcinoma is weak. The efficacy of its anti-tumor effect needs to be improved.

Silk Protein Gene Engineering and Its Applications: Recent Advances in Biomedicine Driven by Molecular Biotechnology.

Silk protein, as a natural polymer material with unique structures and properties, exhibits tremendous potential in the biomedical field. Given the limited production and restricted properties of natural silk proteins, molecular biotechnology has been extensively applied in silk protein genetic engineering to produce novel silk proteins with specific properties. This review outlines the roles of major model organisms, such as silkworms and spiders, in silk protein production, and provides a detailed introduction to the applications of gene editing technologies (eg, CRISPR-Cas9), transgenic expression technologies, and synthetic biology techniques in silk protein genetic engineering.

Long COVID facts and findings: a large-scale online survey in 74,075 Chinese participants.

Background: Research on long COVID in China is limited, particularly in terms of large-sample epidemiological data and the effects of recent SARS-CoV-2 sub-variants. China provides an ideal study environment owing to its large infection base, high vaccine coverage, and stringent pre-pandemic measures.

Methods: This retrospective study used an online questionnaire to investigate SARS-CoV-2 infection status and long COVID symptoms among 74,075 Chinese residents over one year.

Taxonomic notes on the genus Yoshida, 2007 (Araneae, Theridiidae) from China, with two new species.

Four species are reported from Hubei Province, China, including two new species: R. Zhong, J. Liu & Hu, (♂) and R.

Liposome-encapsulated lambda exonuclease-based amplification system for enhanced detection of miRNA in platelet-derived microvesicles of non-small cell lung cancer.

Platelet-derived microvesicles (PMVs) and their encapsulated microRNAs (miRNAs) hold immense potential as biomarkers for early non-small cell lung cancer (NSCLC) diagnosis. This study presents a pioneering liposome-based approach for enhanced miRNA detection within PMVs, employing a lambda exonuclease (λ EXO)-based amplification system encapsulated in immunoliposomes. The platform exploits the novel catalytic functionality of λ EXO, demonstrating its unprecedented capability to catalyze RNA-DNA hybrid substrates.

Chamilactones A and B, Sesquiterpenes from the Endophytic Fungus F5.

A bioassay-guided chemical investigation of the endophytic fungus F5 resulted in the discovery of two novel sesquiterpenes, chamilactones A and B ( and ), with a new 9,10-seco-15--isoilludalane carbon skeleton, together with several biosynthetically related precursors (-). Their structures and absolute configurations were elucidated by the analysis of MS, NMR, calculated C chemical shifts, ECD calculations, and single-crystal X-ray diffraction data. It was proposed that an unprecedented carbon-carbon bond cleavage between C-9 and C-10 in - was the key step in the biosynthetic pathway of and .

Discovery and Characterization of a Fungal N-acetylglucosamine Transferase in the Biosynthesis of Furanone Glycosides.

Malfilamentosides are a class of fungal secondary metabolites characterized by glycosylated furanone scaffold; however, the enzyme that catalyzes the -glycosylation of the furanone core with -acetylglucosamine (GlcNAc) has not yet been identified. In this study, we discovered and identified the biosynthetic gene cluster of the malfilamentosides. and investigations revealed that a glycosyltransferase, MftB, catalyzes the -glycosylation of the furanone scaffold with GlcNAc.

Green Glyphosate Treatment with Ferrihydrite and CaO via Forming Surface Ternary Complex.

Glyphosate (PMG) is a globally used broad-spectrum herbicide and receives environmental concerns because of its moderate persistence and potential carcinogenicity. Traditional PMG treatment methods often suffer from the generation of a more toxic and persistent aminomethylphosphonic acid (AMPA) intermediate. Herein, we develop a green method with ferrihydrite (FH) and CaO (FH/CaO) via regulating the coordination of PMG with FH and Ca, where the phosphonate group of PMG preferentially binds to FH and its carboxylate side complexes with Ca released by CaO, forming a FH-PMG-Ca ternary surface complex.