4 results match your criteria: "The People's Hospital of Tongnan District Chongqing city[Affiliation]"
miR-143-3p/TET1 Axis Regulates GPC1 Through DNA Methylation and Impairs the Malignant Biological Behaviour of HCC via the Hippo Signalling Pathway.
J Cell Mol Med
January 2025
Department of Hepatobiliary Surgery, The People's Hospital of Tongnan District Chongqing city, Chongqing, China.
Hepatocellular carcinoma (HCC) is a malignant tumour that poses a serious threat to human health and places a heavy burden on individuals and society. However, the role of GPC1 in the malignant progression of HCC is unknown. In this study, we analysed the expression of GPC1 in HCC, and its association with poor patient prognosis.
View Article and Find Full Text PDFHMGB1/TREM1 crosstalk between heat-injured hepatocytes and macrophages promotes HCC progression after RFA.
J Cancer Res Clin Oncol
October 2024
Hepatobiliary Surgery, The People's Hospital of Tongnan District Chongqing City, Chongging, China.
Article Synopsis
- The study investigates how tumor recurrence after radiofrequency ablation (RFA) affects survival rates in liver cancer patients and seeks to understand the role of thermal injury on hepatocytes (HCs).
- A mouse model was created to analyze the impact of RFA-induced thermal injury on HCs and the surrounding immune response, finding that damaged HCs release HMGB1, which contributes to an immunosuppressive environment and promotes liver cancer cell invasion.
- The research suggests that targeting HMGB1 could be a potential strategy to reduce liver cancer recurrence following thermal ablation treatments.
USP5 Stabilizes IKBKG Through Deubiquitination to Suppress Ferroptosis and Promote Growth in Non-small Cell Lung Cancer.
Cell Biochem Biophys
October 2024
Department of Thoracic Surgery, The People's Hospital of Tongnan District Chongqing City, Chongqing, China.
Ferroptosis, a distinctive modality of cell mortality, has emerged as a critical regulator in non-small cell lung cancer (NSCLC). The deubiquitinating enzyme USP5 has established an oncogenic role in NSCLC. However, its biological relevance in NSCLC cell ferroptosis is currently unexplored.
View Article and Find Full Text PDFOridonin attenuates liver ischemia-reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis.
Cell Immunol
July 2024
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, China. Electronic address:
Article Synopsis
- The study investigates how Oridonin (Ori), an inhibitor of NLRP3, affects liver ischemia reperfusion injury (IRI) by targeting macrophage pyroptosis, a form of programmed cell death.
- In experiments using mice and liver macrophages, Ori was found to reduce pyroptosis and liver damage by disrupting the interaction between PKM2 and NLRP3 during hypoxia/reoxygenation conditions.
- The results suggest that Ori has protective qualities against liver IRI, making it a possible new treatment option by targeting the PKM2/NLRP3 pathway.