Implantable collamer lens surgery in patients with primary iris and/or ciliary body cysts.

Background: The prevalence of primary iris and/or ciliary body cysts is common in myopia, though asymptomatic in nearly all cases. It's a very valuable thing to study the clinical safety and reliability of implantable collamer lens (ICL) surgery in patients with primary iris and/or ciliary body cysts.

Methods: A total of 108 patients (201 eyes) were included in this retrospective study.

Brittle cornea syndrome: a case report and review of the literature.

Background: To report a patient who presented with bluish scleral discoloration, keratoconus, and progressive high myopia.

Case Presentation: A 6-year-old Chinese female patient presented with a significant bluish discoloration of the sclera in both eyes and extreme corneal thinning with anterior corneal protrusion. General pediatric physical examination was normal for all systems and no genetic disorders known were observed.

A huge lacrimal gland ductule dacryolith with a hairy nucleus: a case report.

Background: Dacryoliths in lacrimal gland ductule are a rare condition and an unusual cause of conjunctivitis. Here we report a case with a large lacrimal gland ductule stone with an unique hairy nucleus.

Case Presentation: A 38-year-old female presented with a red left eye for one month.

Outcomes of open, laparoscopic, and hand-assisted laparoscopic surgeries in elderly patients with right colon cancers: A case-control study.

An increasing proportion of patients aged more than 70 years old are suffering from colorectal cancers. This study aimed to compare the short- and long-terms outcomes between open surgery (OS) or conventional laparoscopic surgery (LS) and hand-assisted laparoscopic surgery (HALS) in treatment of these elderly patients with right colon cancers.We retrospectively reviewed patients who underwent right colon resections for cancers in our institution between June, 2009 and December, 2014.

MiR-30b-5p modulates glioma cell proliferation by direct targeting MTDH.

Malignant glioma is the most common and lethal type of primary tumor of the central nervous system. The incidence of glioma is increasing year by year. In recent years, a variety of new treatment methods have emerged, among which gene therapy has become a hotspot.

Growth hormone-secreting adenoma coexisted with gangliocytoma: a rare case.

A gangliocytoma in the sellar region is extremely rare. We report a rare case of mixed gangliocytoma and growth hormone (GH)-secreting adenoma in a 50-year-old woman, who presented with acromegaly. Laboratory investigations revealed high levels of GH and insulinlike growth factor 1 (IGF-1).

LncRNA-MEG3 inhibits proliferation and metastasis by regulating miRNA-21 in gastric cancer.

Gastric cancer (GC) is one of the most common malignant tumors with high mortality and metastasis rate. Previous studies elucidated that Long non-coding RNA (LncRNA) MEG3 was down-regulated in various tumors and participated in tumor progression. The aim of our study was to investigate the regulating role of MEG3 in cell proliferation and metastasis of GC cells.

Giant Pseudoaneurysm from Superficial Temporal Artery After Trauma.

An 83-year-old woman presented with a lump on her left frontal region. One month ago, she fell and hit the ground with the left side of her head. However, she had no evidence of injury.

Mangiferin induces islet regeneration in aged mice through regulating p16INK4a.

Previous studies by our group on mangiferin demonstrated that it exerts an anti‑hyperglycemic effect through the regulation of cell cycle proteins in 3‑month‑old, partially pancreatectomized (PPx) mice. However, β‑cell proliferation is known to become severely restricted with advanced age. Therefore, it is unknown whether mangiferin is able to reverse the diabetic condition and retain β‑cell regeneration capability in aged mice.

PKM2 in carcinogenesis and oncotherapy.

Tumor cell metabolism is characterized by abundant glucose consumption and aerobic glycolysis. And pyruvate kinase M2 (PKM2) plays a decisive role in glycolysis, significantly contributing to the Warburg effect, tumor growth, angiogenesis, cell division, metastasis and apoptosis. To date, researchers have unraveled the potential of pyruvate kinase M2 as an antitumor target, which suggests a new orientation for oncotherapy.

Tumor suppressive role of miR-194-5p in glioblastoma multiforme.

Glioblastoma multiforme (GBM) is defined by the World Health Organization as the most aggressive form of grade IV glioma, characterized by unrestrained cellular proliferation. microRNAs (miRs) serve important roles in the pathogenesis of GBM. However, the function of miR‑194‑5p in GBM remains unknown.

CRTC2 promotes non-small cell lung cancer A549 migration and invasion in vitro.

Background: CRTC2 is highly expressed in lung cancer and contributes to lung cancer pathogenesis; however, whether CRTC2 promotes lung cancer metastasis remains unknown. In the present study, we investigated the role of CRTC2 in lung cancer metastasis in vitro.

Methods: CRTC2 stable knockdown of lung cancer cell A549 was generated with small hairpin RNA and confirmed by quantitative reverse transcription-PCR and Western blot.

SUMO E3 Ligase PIASy Mediates High Glucose-Induced Activation of NF-B Inflammatory Signaling in Rat Mesangial Cells.

Background: Sumoylation is extensively involved in the regulation of NF-B signaling. PIASy, as a SUMO E3 ligase, has been proved to mediate sumoylation of IB kinase (IKK) and contribute to the activation of NF-B under genotoxic agent stimulation. However, the association of PIASy and NF-B signaling in the pathogenesis of diabetic nephropathy (DN) has not been defined.

Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma.

Uveal melanoma is an aggressive cancer which has a high percentage recurrence and with a worse prognosis. Identify the potential prognostic markers of uveal melanoma may provide information for early detection of recurrence and treatment. RNA sequence data of uveal melanoma and patient clinic traits were obtained from The Cancer Genome Atlas (TCGA) database.

Inhibition of BDNF production by MPP through up-regulation of miR-210-3p contributes to dopaminergic neuron damage in MPTP model.

The neurotrophin brain-derived neurotrophic factor (BDNF) has been involved in supporting of neuron survival. The observation of reduced level of BDNF in the substantia nigra (SN) of Parkinson's disease (PD) patients suggests its important role in neuron protection in PD pathogenesis. However, the mechanism underlying the down-regulation of BDNF in PD was largely unknown.

High dose of nimustine as an add-on treatment for small cell lung cancer with intracranial metastasis: A case report and literature review.

Rationale: Small cell lung cancer (SCLC) characterized by high degree of malignancy and rapid tumor progression. Intracranial metastases often appear at the time of the initial diagnosis or treatment. Besides of radiotherapy, chemotherapy is supposed to have limited effect.

Effects of transthoracic device closure on ventricular septal defects and reasons for conversion to open-heart surgery: A meta-analysis.

Transthoracic device closure (TTDC) is thought to be a promising technology for the repair of ventricular septal defects (VSDs). However, there is considerable controversy regarding the efficacy and safety of TTDC. The present study aimed to compare the benefits and safety of TTDC with those of conventional open-heart surgery (COHS) and analyze the associated factors causing complications, conversion to COHS and reoperation.

A review and meta-analysis of corneal cross-linking for post-laser vision correction ectasia.

Purpose: The aim of this study was to review the safety and stability of cornea cross-linking (CXL) for the treatment of keratectasia after Excimer Laser Refractive Surgery.

Methods: Eligible studies were identified by systematically searching PubMed, Embase, Web of Science and reference lists. Meta-analysis was performed using Stata 12.

Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis.

Objective: The purpose of this study was to evaluate the efficacy and safety of 0.1% tacrolimus eye drops in the tarsal form of vernal keratoconjunctivitis (VKC) and to survey the changes of dendritic cells at the palpebral conjunctiva in patients with VKC by in vivo confocal microscopy.

Methods: A total of 17 patients (34 eyes) with the tarsal form of VKC were enrolled in this prospective, nonrandomized case series.

Interleukin-10/lymphocyte ratio predicts mortality in severe septic patients.

Background: Immunosuppression is common even in the early stage of severe sepsis. Interleukin-10 (IL-10) secretion and lymphocyte exhaustion are the main features of sepsis-induced immunosuppression. However, the relationship between IL-10 and the lymphocyte is still unclear.

Mangiferin attenuates blast-induced traumatic brain injury via inhibiting NLRP3 inflammasome.

There is growing evidence that Mangiferin possess therapeutic benefit during neuroinflammation on various brain injury models due to its anti-inflammatory properties. It is reported that inflammatory plays a crucial role in the pathogenesis of secondary injury induced by the blast-induced traumatic brain injury (bTBI). However, the role of mangiferin in bTBI is yet to be studied.

Female Hormone 17β-Estradiol Downregulated MMP-2 Expression and Upregulated A1PI Expression in Human Corneal Stromal Cells.

Collagens are essential for cornea functions. In non-ocular tissues, it has been demonstrated that sex hormones modulate the collagen remodeling. In this study, we investigated whether the primary female hormone 17β-estradiol plays a role in the expressions of matrix metalloproteinases and proteinase inhibitors in cultured human corneal stromal cells.

Calcifying Pseudoneoplasm of the Neuraxis Arising From the Sacral Canal: Case Report and Review of the Literature.

Background: Calcifying pseudoneoplasm of the spine is an extremely rare lesion and has not yet been reported in the sacral canal.

Case Description: We present the first known case of a calcifying pseudoneoplasm of the neuraxis arising from the sacral canal and discuss the clinicopathological features and neuroradiological findings of this lesion.

Conclusions: Calcifying pseudoneoplasm of the neuraxis can occur throughout the spine, including the sacral canal, and should be included in the differential diagnosis of intraspinal calcified lesions.

The effect of resin infiltration vs. fluoride varnish in enhancing enamel surface conditions after interproximal reduction.

To assess the effect of resin infiltration vs. fluoride varnish in enhancing enamel surface conditions after interproximal reduction (IPR). After IPR procedures, 84 human enamel specimens were divided into three groups, group A/ group B was treated by fluoride varnish/resin infiltration according to the manufacturers' instructions, group C were treated with nothing.