134 results match your criteria: "The Pennine Acute Hospitals NHS Trust.[Affiliation]"

Pathological findings associated with the updated European Society of Cardiology 2022 guidelines for preoperative cardiac testing: an observational cohort modelling study.

Br J Anaesth

April 2024

Department of Anaesthesiology, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.

Article Synopsis
  • The 2022 European Society of Cardiology guidelines for preoperative evaluations aimed to improve the detection of pathological findings compared to the 2014 guidelines.
  • A study analyzed data from 15,529 patients and found that the updated recommendations changed testing protocols for many, but did not enhance the overall effectiveness of cardiac testing.
  • The use of B-type natriuretic peptide (NT-proBNP) for risk estimation did not improve pathological findings, and adherence to the new guidelines showed no significant link to major adverse cardiovascular events.
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Background: Guidelines endorse self-reported functional capacity for preoperative cardiovascular assessment, although evidence for its predictive value is inconsistent. We hypothesised that self-reported effort tolerance improves prediction of major adverse cardiovascular events (MACEs) after noncardiac surgery.

Methods: This is an international prospective cohort study (June 2017 to April 2020) in patients undergoing elective noncardiac surgery at elevated cardiovascular risk.

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Article Synopsis
  • The study aimed to update the National Institute for Health and Care Excellence (NICE) guidelines on brain imaging for non-small cell lung cancer (NSCLC) using real-world data from 444 patients in the UK instead of previous modeled assumptions.
  • Real-world findings showed lower rates of occult brain metastases than NICE had reported, and a significantly higher percentage of patients with stage III NSCLC completed their planned treatment, indicating better outcomes than previously assumed.
  • The analysis concluded that while brain imaging is cost-effective for stage III NSCLC treatment, it is not cost-effective for stage II, challenging the previous NICE recommendations for this group.
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Article Synopsis
  • This study aimed to evaluate the surgical and postoperative management of displaced paediatric supracondylar elbow fractures in the UK, addressing a debate in current practices.
  • A total of 972 patients were studied, with findings showing that the average age of injury was 6.3 years and that most patients received Kirschner wire fixation.
  • Results indicated differences in surgical practice based on the supervising consultant's specialty, with paediatric orthopaedic consultants performing less wire removal in theatre compared to non-paediatric consultants.
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Optimizing biologic therapy in inflammatory bowel disease: a Delphi consensus in the United Arab Emirates.

Therap Adv Gastroenterol

December 2021

Department of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester Academic Health Sciences, University of Manchester, Manchester, UK.

Background: Inflammatory bowel diseases (IBD) are chronic, relapsing-remitting inflammatory conditions with a substantial negative impact on health-related quality of life and work productivity. Treatment of IBD has been revolutionized by the advent of biologic therapies, initially with anti-TNF agents and more recently with multiple alternatives targets, and yet more under development.

Objectives: Approximatively one third of patients do not respond to biologic therapy and more importantly a significant proportion experiences partial response or loss of response during treatment.

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Dietary beliefs and recommendations in inflammatory bowel disease: a national survey of healthcare professionals in the UK.

Frontline Gastroenterol

December 2020

Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK.

Background: The role of diet in inflammatory bowel disease (IBD) remains incompletely understood. Knowledge around the actual dietary advice healthcare professionals provide to individuals with IBD is scarce. Our objective was to describe the dietary beliefs of healthcare professionals and dietary recommendations made to people with IBD.

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Quantitative Magnetic Resonance Imaging in Perianal Crohn's Disease at 1.5 and 3.0 T: A Feasibility Study.

Diagnostics (Basel)

November 2021

Translational Medical Sciences Academic Unit, School of Medicine, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, UK.

Article Synopsis
  • Perianal Crohn's Disease (pCD) is a key type of Crohn's Disease where effective monitoring is challenged due to unreliable disease measures.
  • Qualitative MRI has become valuable in diagnosing and tracking pCD, while quantitative MRI techniques like diffusion-weighted imaging (DWI) and T2 relaxometry offer potential improvements in diagnosis.
  • In a study of 25 pCD patients, while no significant changes were observed in MRI measurements after 12 weeks of treatment, clinical indicators like PDAI and CRP did decrease, suggesting these could help predict treatment response more effectively.
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Editorial commentary on Indian Journal of Gastroenterology-September-October 2021.

Indian J Gastroenterol

October 2021

Section of Inflammatory Bowel Diseases, Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK.

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Median arcuate ligament syndrome or celiac artery compression syndrome is one of the abdominal vascular compression syndromes due to compression of proximal celiac artery by the median arcuate ligament. The median arcuate ligament unites diaphragmatic crura on either side at the level of aortic hiatus. The ligament has a low insertion causing compression of the celiac artery resulting in clinical symptoms of postprandial pain and weight loss.

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Clinician perspectives on the use of artificial intelligence in inflammatory bowel disease.

Gastrointest Endosc

September 2021

Department of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK; Manchester Academic Health Sciences, University of Manchester, Manchester, UK.

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The dietary practices and beliefs of people living with older-onset inflammatory bowel disease.

Eur J Gastroenterol Hepatol

December 2021

Division of Diabetes, Endocrinology & Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester.

Background And Objectives: The role of diet in inflammatory bowel disease (IBD) remains incompletely understood. Studies have previously examined dietary practices in IBD, but none have specifically focused on older-onset disease. IBD may put vulnerable groups at risk of nutritional deficiency and associated complications, potentially heightened by comorbidities, frailty and polypharmacy.

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Amyloidosis of the Urinary Bladder: A Systematic Review and a Proposed Management Algorithm.

Urology

October 2021

School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece; Urology Department, The Pennine Acute Hospitals NHS Trust, Manchester, UK.

Objective: To propose an algorithm for the management of bladder amyloidosis based on a systematic review of the literature, given that the bladder is the second most commonly affected organ of the urinary tract in the course of systemic or localized amyloidosis.

Methods: We searched PubMed, Cochrane Library and Scopus databases utilizing PRISMA methodology from inception to November 30, 2020 (PROSPERO: CRD42020207855).

Results: We included 76 studies with 184 patients (9 case series and 67 case reports).

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Effectiveness of Third-Class Biologic Treatment in Crohn's Disease: A Multi-Center Retrospective Cohort Study.

J Clin Med

June 2021

Sheba Medical Center, Tel Hashomer, Israel, Department of Gastroenterology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 52621, Israel.

Article Synopsis
  • This study looked into how well two medications, ustekinumab (UST) and vedolizumab (VDZ), work as third-line treatments for patients with Crohn's disease who haven’t responded well to other medications.
  • Researchers included 204 patients, with 76% receiving VDZ followed by UST, and 24% the opposite. After 16 to 22 weeks, about half of patients in both groups showed a response to the treatment.
  • By week 52, similar response rates (around 86%) were observed, with about a quarter to a third of patients attaining clinical remission, indicating that both medications were similarly effective as third-class therapies. *
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Objectives: To devise a novel, simple chest x-ray (CXR) scoring system which would help in prognosticating the disease severity and ability to predict comorbidities and in-hospital mortality.

Methods: We included a total of 343 consecutive hospitalised patients with COVID-19 in this study. The chest x-rays of these patients were scored retrospectively by three radiologists independently.

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Does Similarity Breed Contempt? A Review of the Use of Biosimilars in Inflammatory Bowel Disease.

Dig Dis Sci

August 2021

Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Center, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Article Synopsis
  • The use of monoclonal antibodies targeting tumor necrosis factor-α has significantly improved treatment outcomes for inflammatory bowel disease (IBD), enhancing patient quality of life and reducing hospital visits and steroid use.
  • However, these biologics are expensive, leading to high medical costs for IBD patients.
  • To address affordability, biosimilars—similar but not identical therapeutic antibodies—have been introduced, but their acceptance varies across regions, prompting a discussion of their benefits, barriers to use, and safety in clinical studies.
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Editorial commentary on Indian Journal of Gastroenterology-July-August 2021.

Indian J Gastroenterol

August 2021

Section of Inflammatory Bowel Diseases, Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK.

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Editorial: determining disability in IBD - 'See(k) and you shall find'.

Aliment Pharmacol Ther

June 2021

Section of IBD, The Pennine Acute Hospitals NHS Trust, Manchester Academic Health Sciences, University of Manchester, Manchester, UK.

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Editorial commentary on the Indian Journal of Gastroenterology- May-June 2021.

Indian J Gastroenterol

June 2021

Section of Inflammatory Bowel Diseases, Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK.

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Editorial commentary on the Indian Journal of Gastroenterology - March-April 2021.

Indian J Gastroenterol

April 2021

Head- Section of Inflammatory Bowel Diseases,Division of Gastroenterology, The Pennine Acute Hospitals NHS Trust, Manchester, UK.

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