2 results match your criteria: "The Panum Institute 12.5[Affiliation]"
Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heart.
Regul Pept
February 2008
Department of Biomedical Sciences and The Danish National Research, Foundation Centre for Heart Arrhythmia, University of Copenhagen, The Panum Institute 12.5, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
Glucagon-Like Peptide-1 (GLP-1) is an incretin peptide secreted from intestinal L-cells, whose potent plasma glucose-lowering action has prompted intense efforts to develop GLP-1 receptor-targeting drugs for treatment of diabetic hyperglycemia. More recently, GLP-1 and its analogues have been shown to exert cardiovascular effects in a number of experimental models. Here we tested exendin-4 (Exe-4), a peptide agonist at GLP-1 receptors, and GLP-1(9-36) amide, the primary endogenous metabolite of GLP-1 (both in the concentration range 0.
View Article and Find Full Text PDFProtection by 6-aminonicotinamide against oxidative stress in cardiac cells.
Pharmacol Res
October 2006
Department of Medical Physiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, The Panum Institute 12.5, Blegdamsvej 3, Copenhagen N, Denmark.
Oxidative stress at the time of reperfusion is a major aspect of ischemia-reperfusion injury in heart as well as in other organs. There is a continuing interest in development of pharmacological approaches to alleviate this injury. 6-Aminonicotinamide (6AN) has been shown to diminish myocardial necrosis following global ischemia in an isolated rat heart, apparently by limiting the oxidative injury component.
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