14 results match your criteria: "The Palatine Centre[Affiliation]"

Article Synopsis
  • Cigarette smoking is the most impactful modifiable risk factor for multiple sclerosis (MS) and is linked to increased comorbidities and polypharmacy in patients.
  • The study investigated the relationship between the degree of smoking dependence, polypharmacy, and personality traits in MS patients using personality assessments.
  • Results indicated that patients with severe smoking dependence exhibited higher neuroticism scores and lower extraversion scores, and those on polypharmacy also demonstrated higher neuroticism compared to those not on multiple medications.
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Hodgkin/Reed-Sternberg cells induce GPNMB expression and release from macrophages to suppress T-cell responses to the Epstein-Barr virus-encoded LMP2A protein.

Haematologica

January 2025

Limerick Digital Cancer Research Centre, Bernal Institute and Health Research Institute and School of Medicine, University of Limerick, Limerick, Ireland; Royal College of Surgeons in Ireland Medical University of Bahrain, Manama, Bahrain; Department of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Olomouc.

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The recent SARS-CoV-2 pandemic and the vaccination campaign posed a challenge to patients with autoimmune disease, such as multiple sclerosis (MS). We aimed for investigating whether psychological/sociodemographic/clinical characteristics of MS patients are associated with SARS-CoV-2 vaccination status and self-reported vaccination side effects (SEs). We have asked patients with MS about their willingness to receive recommended standard vaccinations pre-pandemically since June 2019.

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Article Synopsis
  • Cyclic peptides are important for drug development, but their synthesis can be challenging.
  • The 3-aminoazetidine (3-AAz) subunit enhances the synthesis of small head-to-tail cyclic peptides, improving cyclization of various peptide lengths.
  • Additionally, the 3-AAz allows for further modifications of the macrocyclic peptides, enabling the creation of tagged compounds like dyes and biotin.
  • XRD analysis shows that the azetidine structure promotes a stable, all-trans conformation and boosts resistance against proteases.
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Background: A total of 30-40% of diffuse large B cell lymphoma (DLBCL) patients will either not respond to the standard therapy or their disease will recur. The first-line treatment for DLBCL is rituximab and combination chemotherapy. This treatment involves the chemotherapy-induced recruitment of tumor-associated macrophages that recognize and kill rituximab-opsonized DLBCL cells.

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Polypharmacy (intake of ≥5 drugs) is an important issue for patients with chronic diseases such as multiple sclerosis (MS). We aimed to assess the prevalence of polypharmacy with regard to the severity of anxiety/depression and to comorbidities. Therefore, 374 MS patients from two German neurological sites were examined for drug burden, comorbidities, disability level and psychopathological measures capturing depression and anxiety using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D).

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Background: The term "weaponized autism" is frequently used on extremist platforms. To better understand this, we conducted a discourse analysis of posts on Gab, an alt-right social media platform.

Methods: We analyzed 711 posts spanning 2018-2019 and filtered for variations on the term "weaponized autism".

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General vaccination willingness and current vaccination status in relation to clinical and psychological variables in patients with multiple sclerosis.

Vaccine

May 2022

Ecumenic Hainich Hospital gGmbH, Pfafferode 102, 99974 Mühlhausen, Germany; University of Hull, Faculty of Health Sciences, Cottingham Rd, Hull HU6 7RX, UK; Durham Law School, Durham University, The Palatine Centre, Stockton Road, Durham, DH1 3LE, UK. Electronic address:

Background: Infections can have a significant impact on morbidity and mortality in multiple sclerosis (MS) patients. Therefore, vaccinations are of immense importance. If vaccination willingness is to be increased, possible influencing factors should be identified.

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Vaccine Liability in the Light of Covid-19: A Defence of Risk-Benefit.

Med Law Rev

May 2022

Durham Law School, Durham University, The Palatine Centre, Durham City DH1 3LE, UK.

Vaccines have played an essential role in advancing medical treatment in the twentieth and twenty-first centuries. However, no medical intervention is risk free, and vaccines are no exception to that rule. This article considers how lawyers have confronted or eschewed risk-benefit in the context of determining defectiveness in vaccine liability, with emphasis on the UK, European Union, and US experiences.

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How will e-cigarettes affect health inequalities? Applying Bourdieu to smoking and cessation.

Int J Drug Policy

April 2018

Durham University, Anthropology Department, The Palatine Centre, Stockton Road, Durham DH1 3LE, UK. Electronic address:

This paper uses the work of Bourdieu to theorise smoking and cessation through a class lens, showing that the struggle for distinction created the social gradient in smoking, with smoking stigma operating as a proxy for class stigma. This led to increased policy focus on the health of bystanders and children and later also to concerns about electronic cigarettes. Bourdieu's concept of habitus is deployed to argue that the e-cigarette helps middle-class smokers resolve smoking as a symptom of cleft habitus associated with social mobility or particular subcultures.

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Survival patterns in teenagers and young adults with cancer in the United Kingdom: Comparisons with younger and older age groups.

Eur J Cancer

November 2015

Clinical Outcomes Unit, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester M20 4BX, UK. Electronic address:

Aims: We aimed to describe and compare survival in teenagers and young adults (TYAs) with cancer to that of younger children and older adults, to identify sub-populations at greater or lesser risk of death.

Methods: We compared survival in cancer patients diagnosed in the United Kingdom aged 13-24 years (TYAs) to those aged 0-12 (children) and 25-49 years (adults) using the National Cancer Data Repository. All cases had a first cancer diagnosis between 1st January 2001 and 31st December 2005 with censor date 31st December 2010 or death if earlier.

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Trends in survival for teenagers and young adults with cancer in the UK 1992-2006.

Eur J Cancer

September 2015

Centre for Paediatric, Teenage and Young Adult Cancer, Institute of Cancer Sciences, University of Manchester, Young Oncology Unit, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK. Electronic address:

Background: Although relatively rare, cancer in teenagers and young adults (TYA) is the most common disease-related cause of death and makes a major contribution to years of life lost in this age group. There is a growing awareness of the distinctive needs of this age group and drive for greater understanding of how outcomes can be improved. We present here the latest TYA survival trends data for the United Kingdom (UK).

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Background: Chlamydia infections represent a major public health problem, with a prevalence of 6-10% in family planning clinic (FPC) attendees. There has been recent concern expressed about the management of these patients in terms of treatment and follow-up.

Objective: An audit was carried out to monitor referral compliance and outcome with care pathways of women attending our FPC who were found to be positive for chlamydia.

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