Sequencing of Androgen-Deprivation Therapy With External-Beam Radiotherapy in Localized Prostate Cancer: A Phase III Randomized Controlled Trial.

Purpose: Dose-escalated radiotherapy (RT) with androgen-deprivation therapy (ADT) is a standard definitive treatment of localized prostate cancer (LPCa). The optimal sequencing of these therapies is unclear. Our phase III trial compared neoadjuvant versus concurrent initiation of ADT in combination with dose-escalated prostate RT (PRT).

SU-E-T-87: The Effect of Bleaching Wavelengths on the Regeneration of the Optically Stimulated Luminescence Signal of NanoDot Dosimeters Pre-Exposed to High-Doses.

Purpose: To investigate the effect of bleaching wavelengths on the regeneration of optically stimulated luminescence (OSL) signals in Al O :C nanoDot dosimeters pre-exposed to high doses. Regeneration is the increase in the OSL signal during storage of a bleached nanoDot that was previously pre-exposed to a high dose. This phenomenon affects the accuracy of a calibration protocol proposed by Jursinic 2010 (Med.

SU-E-T-90: Investigation of Different Bleaching Wavelengths on the Absorbed-Dose Sensitivity of NanoDot OSLDs Exposed to 6 MV X-Ray Beams.

Purpose: To determine the effect of different bleaching wavelengths on the luminescence response of Al O :C optically stimulated luminescence detectors (OSLDs) exposed to accumulated doses of 6 MV photon beams.

Methods: OSLDs of the nanoDot type were used and readout with a microStar InLight reader. To determine the effect of different bleaching wavelengths on the luminescence response of nanoDot OSLDs, we optically reset (bleached) the OSLDs with 26 W fluorescent lamps in two modes: (i) directly under the lamps for 10, 120 and 600 min; and (ii) with a long pass filter for 55, 600 and 2400 min.

BLP-25 liposomal vaccine: a promising potential therapy in non-small-cell lung cancer.

Despite marginal improvements in survival gained from multimodality treatment, long-term survival rates remain low for lung cancer, which remains the leading cause of cancer-related mortality in North America. BLP25 liposomal (L-BLP25) vaccine (Stimuvax) is a promising liposomal vaccine designed to generate an immune response against MUC1, a glycoprotein expressed on the cell surface of many normal epithelial tissues and over or aberrantly expressed on many carcinoma cells, including non-small-cell lung cancer (NSCLC). MUC1 is potentially a good target for immunotherapy, as evidenced by preclinical data and in Phase I and II clinical trials demonstrating the potential early activity of L-BLP25 with minimal toxicity in NSCLC.

The comparative survival of renal leiomyosarcoma.

Introduction: Leiomyosarcoma of the kidney and renal pelvis is a rare tumor that, on the basis of limited data, has been ascribed a particularly poor prognosis compared to other subtypes of renal malignancy. Here the population-based Surveillance, Epidemiology, and End Results (SEER) registry is used to study the survival of renal leiomyosarcomas.

Methods: There were 95,935 cases of invasive cancer of the kidney and renal pelvis retrieved from the SEER registry to provide 112 cases of leiomyosarcoma.

Lymph node-based prognostics: limitations with individualized cancer treatment.

Objectives: Clinicians will commonly individualize adjuvant cancer therapy, on the basis of the number of involved lymph nodes and other clinicopathological factors, under the assumption that despite the expected statistical variability of such data one can nonetheless garner useful information for the individual case. Here the scientific basis of this assumption will be examined.

Methods: Survival data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program for 19,107 breast, 4,234 gastric, and 4,058 rectal cancers were studied with Kaplan-Meier estimates and Cox proportionate hazard models.

Prostatic irradiation is not associated with any measurable increase in the risk of subsequent rectal cancer.

Purpose: To investigate a putative increased risk of rectal cancer subsequent to prostatic radiotherapy.

Methods And Materials: In an analysis of the Surveillance, Epidemiology, and End Results registry, we compared men who had radiotherapy for prostatic carcinoma with those treated surgically and those treated with neither modality. Kaplan-Meier analyses for the time to failure from rectal cancer were performed between age-matched subgroups of the three cohorts.