578 results match your criteria: "The Oncology Institute "Prof. Dr. Ion Chiricuta"[Affiliation]"
Int J Mol Sci
November 2024
Centre for Systems Biology, Biodiversity and Bioresources, Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 5-7 Clinicilor Street, 400006 Cluj-Napoca, Romania.
Despite the growing interest in using natural compounds for disease prevention and treatment, (wild garlic), known for its therapeutic properties, has not been extensively studied for its chemical composition and biological activities. Therefore, this study aims to explore the in vitro antioxidant, antibacterial, and antitumor activities of extracts according to their functional phytochemical profile, while assessing whether ultrasound-assisted extraction (UAE) enhances bioactive properties in comparison to conventional maceration (CM). Both extracts were characterized by spectrophotometric methods and LC-ESI+-MS.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Background: Brain metastases (BM) from gastric cancer (GC) are rare but associated with poor prognosis, significantly impacting patient survival and quality of life. The objective of this systematic review and meta-analysis is to consolidate existing research on BM from GC, evaluate the incidence and clinical outcomes, and explore the effectiveness of treatment options.
Methods: A systematic search was conducted across the Medline, Web of Science, and Scopus databases, following PRISMA guidelines.
BMC Genom Data
November 2024
Department of Microscopic Morphology, Genetics Discipline, Victor Babeș University of Medicine and Pharmacy, 2 Eftimie Murgu Square Street, Timișoara, 300041, Romania.
Lynch syndrome (LS) is one of the most common hereditary cancer syndrome in human populations, associated with germline variants in MLH1, MSH2/EPCAM, MSH6 and PMS2 genes. The advent of next generation sequencing has proven a significant impact in germline variant detection in the causative genes; however, a large proportion of patients with clinical criteria still receive uncertain or negative results. PMS2 is the least frequent reported gene, associated with up to 15% of LS cases with late-onset disease and low penetrance phenotype; however, the proportion of PMS2-LS cases is considered to be highly underestimated.
View Article and Find Full Text PDFRSC Med Chem
October 2024
Research Center on Fundamental and Applied Heterochemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University 11 Arany Janos str RO-400028 Cluj-Napoca Romania +40 264 593833.
New -substituted AB-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions, respectively. The free porphyrins were further used in the synthesis of new indium(iii) or zinc(ii) porphyrin complexes. All porphyrins exhibit red fluorescence emission in solution, a property that remains unimpaired following internalisation in ovarian A2780 cancer cells, as evidenced by fluorescence microscopy images.
View Article and Find Full Text PDFSci Rep
November 2024
Belgian Nuclear Research Centre, Radiobiology Unit, SCK•CEN, Mol, Belgium.
J Clin Med
October 2024
Radiology Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
J Thorac Oncol
November 2024
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology, BC Cancer Agency, Vancouver, Canada.
Med Pharm Rep
October 2024
Department of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Background And Aims: Non-small cell lung cancer (NSCLC) treatment is challenged by late detection and limited therapeutic options. Aberrant DNA methylation, a common epigenetic alteration in NSCLC, offers new therapeutic avenues. This study aims to evaluate the combined effects of 5-Azacytidine (5-Aza), an epigenetic modifier, and ionizing radiation (IR) on NSCLC, exploring the underlying molecular mechanisms and therapeutic potential.
View Article and Find Full Text PDFInt J Gynecol Cancer
January 2025
Surgical Oncology, Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania.
Objectives: Interval debulking surgery has similar outcomes and less morbidity compared with primary debulking in advanced ovarian cancer. However, there is controversy regarding the selection of chemotherapy-resistant clones. Complete resection is an essential prerequisite, and near-infrared surgery combined with various techniques for highlighting malignant foci strives to achieve actual complete resection.
View Article and Find Full Text PDFCase Rep Oncol
September 2024
Institute of Oncology "Prof Dr. Ion Chiricuță", Cluj-Napoca, Romania.
Introduction: Clear cell sarcoma (CCS) of soft tissue is a rare type of soft tissue sarcoma affecting usually lower extremities in young adults. The main challenges in the management of this disease include difficulties in diagnosis, aggressiveness of the cancer with rapid progression, and inadequate treatment, especially in small centers with few cases.
Case Presentation: We present a case of a young woman diagnosed with CCS of soft tissue, stage IV.
Medicina (Kaunas)
October 2024
Department of Oncological Surgery and Gynecological Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania.
J Cell Mol Med
October 2024
Research Center for Advanced Medicine MedFUTRE, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Front Oncol
October 2024
Department of Medical Oncology, The Oncology Institute Prof. Dr. Ion Chiricuţă, Cluj-Napoca, Romania.
Ther Adv Med Oncol
October 2024
Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Background: Dysregulated pathways in cancer may be hub addicted. Identifying these dysregulated networks for targeting might lead to novel therapeutic options.
Objective: Considering the hypothesis that central hubs are associated with increased lethality, identifying key hub targets within central networks could lead to the development of novel drugs with improved efficacy in advanced metastatic solid tumors.
Heliyon
October 2024
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337, Cluj-Napoca, Romania.
Pancreatic cancer (PC) is an intricate malignancy with poor prognosis. In the present state of the art review paper and clinical trial trend analysis, we explore the current clinically employed state of pancreatic cancer body of knowledge and future research directions. When considering PDACs' molecular biology, we underline the role of PanIN in carcinogenesis and mutational gain, as well as the distinctive tumor microenvironment with the characteristic dense fibrotic stroma.
View Article and Find Full Text PDFCureus
October 2024
Department of Clinical Pharmacology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, ROU.
A functional hydrogel containing biopolymer microcarriers loaded with dexamethasone was developed to address the hearing loss that results from cisplatin ototoxicity. The drug delivery platform was tested both in vitro in the HEI-OC1 inner ear cell line and in vivo in a rat animal model. The newly described formula offered prolonged release of the contained dexamethasone for up to six days and transformed into a solid state at body temperature, thus counteracting its clearing through the Eustachian tube when injected into the middle ear.
View Article and Find Full Text PDFFront Pediatr
September 2024
2nd Pediatric Clinic, Emergency Clinical Hospital for Children, Cluj-Napoca, Romania.
Cureus
September 2024
Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, ROU.
MiRNAs are a class of non-coding RNAs acting as gene expression regulators by modulating the lifespan of messenger RNA. Commonly referred to as the most frequent leukemia in the Western world, chronic lymphocytic leukemia (CLL) is a lymphoproliferative malignancy characterized by clonal expansion of CD19, CD23, and CD5-positive mature B-cells. While this pathology is regarded as less aggressive and has a variety of treatment options, the cause of its clinical heterogeneity is not yet understood.
View Article and Find Full Text PDFJ Thorac Oncol
January 2025
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.
Arch Ital Urol Androl
October 2024
Department of Urology, Institute of Oncology "Prof. Dr. Ion Chiricuţă", Cluj-Napoca.
Diagnostics (Basel)
September 2024
Department of Oncological Surgery and Gynecological Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Background And Objectives: Rectal cancer accounts for approximately one-third of colorectal cancers, with over 340,000 deaths globally in 2022. Despite advancements in treatment, the five-year overall survival for locally advanced rectal cancer (LARC) remains at 74%, with significant morbidity. B7H3 (CD276), an immune checkpoint protein, plays a role in tumor progression and resistance to therapy, and correlates with poor prognosis in various cancers, including colorectal cancer.
View Article and Find Full Text PDFBiomedicines
September 2024
Department of Neurosciences, Discipline of Psychiatry and Pediatric Psychiatry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 43 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
Prostate cancer (PC) represents the second most common diagnosed cancer in men. The burden of diagnosis and long-term treatment may frequently cause psychiatric disorders in patients, particularly depression. The most common PC treatment option is androgen deprivation therapy (ADT), which may be associated with taxane chemotherapy.
View Article and Find Full Text PDFCancers (Basel)
September 2024
Department of Medical Imaging and Nuclear Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
The role of magnetic resonance imaging (MRI) in rectal cancer management has significantly increased over the last decade, in line with more personalized treatment approaches. Total neoadjuvant treatment (TNT) plays a pivotal role in the shift from traditional surgical approach to non-surgical approaches such as 'watch-and-wait'. MRI plays a central role in this evolving landscape, providing essential morphological and functional data that support clinical decision-making.
View Article and Find Full Text PDFEur J Cancer
November 2024
Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.
Background: We report 5-year efficacy and safety outcomes from CheckMate 9LA in patients with metastatic non-small cell lung cancer (mNSCLC) and exploratory analyses in key patient subgroups.
Methods: Adults with stage IV/recurrent NSCLC and no sensitizing EGFR/ALK alterations were randomized to receive nivolumab plus ipilimumab with chemotherapy (n = 361) or chemotherapy (n = 358). Outcomes were assessed in all randomized patients and subgroups.
Int J Nanomedicine
September 2024
Nanobiophotonics and Laser Microspectroscopy Centre, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania.