9,378 results match your criteria: "The Ohio State University-Wexner Medical Center[Affiliation]"

Article Synopsis
  • Non-Hispanic Black (NHB) men have a higher risk of prostate cancer (PCa) incidence and mortality than Non-Hispanic White (NHW) men, but this study focuses on incidental PCa cases from two North American cohorts.
  • The research analyzed data from SEER (2004-2017) and Henry Ford Health (1995-2022) to compare cancer-specific mortality (CSM) and management of incidental PCa between NHB and NHW men, finding no major pathological differences except for slightly elevated PSA levels in NHB men.
  • Conclusions indicate that both groups had similar survival outcomes, challenging previous beliefs that racial disparities significantly affect prostate cancer mortality after incidental diagnoses.
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Virtual interviews play a crucial role in the ranking process. National Resident Matching Program (NRMP) data shows a median number of 23.5 interviews per applicant.

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Article Synopsis
  • * Many cases of HCC are diagnosed inoperable, necessitating alternative treatment options beyond surgery, despite some cases being treatable through surgical resection or transplantation.
  • * This review focuses on key locoregional therapies for HCC in NAFLD patients, such as transarterial chemoembolization (TACE), bland transarterial embolization (TAE), trans
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Risk-Stratified Radiotherapy in Pediatric Cancer.

Cancers (Basel)

October 2024

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Article Synopsis
  • Despite significant improvements in the cure rate of childhood cancer over recent decades, survivors often face late effects, particularly from radiotherapy.
  • Recent strategies aim to reduce or eliminate radiotherapy in children who respond well to chemotherapy, as seen in conditions like Hodgkin lymphoma and certain Wilms tumors.
  • Innovations like molecular subtyping in medulloblastoma and targeted dose escalation in rhabdomyosarcoma and Ewing sarcoma are being explored to enhance treatment outcomes while minimizing late toxicity.
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The mechanical properties of sclera play an important role in ocular functions, protection, and disease. Modulating the sclera's properties by exogenous crosslinking offers a way to expand the tissue's range of properties for study of the possible influences on the eye's behavior and diseases such as glaucoma and myopia. The focus of this work was to evaluate the effects of genipin crosslinking targeting the porcine perilimbal sclera (PLS) since the stiffness of this tissue was previously found in a number of studies to influence the eye's intraocular pressure (IOP).

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Background: Structured preparation is necessary to conduct quality improvement (QI) strategies that are relevant to the problem, feasible, appropriately resourced, and potentially effective. Recent work suggests that improvement efforts are suboptimally conducted. Our goal was to determine how well preparation for surgical QI is undertaken, including detailing the problem, setting project goals, and planning an intervention.

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Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details in vivo, the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain measurements.

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Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

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Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

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Introduction: Over 20 states and local jurisdictions in the U.S. have imposed e-cigarette taxes.

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Article Synopsis
  • The advanced lung cancer inflammation index (ALI) combines inflammation and nutrition data to predict overall survival (OS) in patients with intrahepatic cholangiocarcinoma (ICC) who have undergone surgery.
  • In a study of 1,045 patients, low ALI was found to be an independent risk factor for worse OS, with those having low ALI showing significantly lower 5-year survival rates.
  • ALI performed comparably to other inflammatory markers in predicting survival while demonstrating slightly better model fit and accuracy, indicating the value of integrating nutritional and inflammatory data in prognostic assessments.
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Background And Purpose: Posterior circulation strokes, accounting for 20% of acute ischemic strokes, significantly contribute to morbidity and mortality. Fibrinolysis by rtPA improves outcomes in stroke but the risk of intracranial hemorrhage limits benefit. Arterial recanalization of basilar artery occlusion by thrombolysis or endovascular thrombectomy improves outcomes in posterior circulation strokes.

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Article Synopsis
  • - Lung transplantation is the key treatment for severe lung diseases, but less than 20% of available lungs are used due to issues like limited time and poor organ quality.
  • - Ischemia reperfusion injury (IRI) is a major factor causing immediate poor function of transplanted lungs, involving various cellular damage pathways and inflammation.
  • - Pyroptosis, a specific type of programmed cell death, significantly contributes to early injury after transplantation, and targeting this pathway could improve lung transplant outcomes.
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Objectives: The American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) recommend cold ischemia time (cIT) be <60 min, and formalin fixation time (FFT) 6-72 h, to optimize immunohistochemistry (IHC) based on breast cancer data. We assessed whether cIT and FFT impact IHC in endometrial cancer (EC), and determined which factors affect cIT and FFT.

Methods: Surgical EC cases from 2019 to 2023 were reviewed.

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The aim of the present systematic review is to evaluate the effects of different photobiomodulation therapy (PBMT) approaches in oncological treatment practices. The review follows the PRISMA guidelines. Specifically, the review is composed of laser PBMT and LED PBMT.

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The establishment of the Liver Imaging Reporting and Data System (LI-RADS) in 2011 provided a comprehensive approach to standardized imaging, interpretation, and reporting of liver observations in patients diagnosed with or at risk for hepatocellular carcinoma (HCC). Each set of algorithms provides criteria pertinent to the various components of HCC management including surveillance, diagnosis, staging, and treatment response supported by a detailed lexicon of terms applicable to a wide range of liver imaging scenarios. Before its widespread adoption, the variability in the terminology of diagnostic criteria and definitions of imaging features led to significant challenges in patient management and made it difficult to replicate findings or apply them consistently.

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Renal cell carcinoma (RCC) is the most common primary renal malignancy. Prevalence of RCC in developed countries has slowly increased. Although partial or total nephrectomy has been the first-line treatment for early-stage RCC, improved or similar safety and treatment outcomes with locoregional therapies have challenged this paradigm.

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Background: Frailty correlates with worse postoperative outcomes and higher surgical cost, but the long-term impact on healthcare use remains ill-defined. We sought to evaluate patterns of healthcare use pre- and postsurgery among patients with gastrointestinal cancer and characterize the association with frailty.

Study Design: Data on patients who underwent surgical resection for liver, biliary, pancreatic, colon and rectal cancer were obtained from the SEER-Medicare database from 2005 to 2020.

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Objective: The COVID-19 pandemic required unprecedented changes to emergency medical services (EMS) educational frameworks in the United States. It is unclear if pandemic-related changes impacted paramedic educational outcomes. We aimed to evaluate curricular and performance changes resulting from the initial COVID-19 pandemic on paramedic educational programs.

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Objectives: Despite the significant disease burden due to cardiac arrest, there is a relative paucity of randomized controlled trials (RCTs) to inform definitive management. We aimed to evaluate the current scope of cardiac arrest RCTs published between 2015 and 2022.

Methods: We conducted a search in October 2023 of MEDLINE, Embase, and Web of Science for cardiac arrest RCTs.

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