1 results match your criteria: "The Ohio State University and The OSU Comprehensive Cancer Center[Affiliation]"
F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy.
Mol Cell
January 2019
Department of Biomedical Informatics, The Ohio State University and The OSU Comprehensive Cancer Center, Columbus, OH, USA. Electronic address:
PARP inhibitor (PARPi) therapy targets BRCA1/2 mutant tumor cells, but acquired resistance limits its effectiveness. In this issue of Molecular Cell, Marzio et al. (2019) identify a novel mechanism of resistance to PARPi through regulation of RAD51 protein stability via an SCF ubiquitin ligase dependent on EMI1.
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