5 results match your criteria: "The Ohio State University Davis Heart and Lung Research Institute[Affiliation]"
Estimation of myocardial fibrosis in humans with dual energy CT.
J Cardiovasc Comput Tomogr
February 2020
The Ohio State University Davis Heart and Lung Research Institute, 473 W. 12th Ave, Columbus, OH, 43210, USA. Electronic address:
Background: The current clinical standard for in vivo imaging of myocardial fibrosis is contrast-enhanced cardiac magnetic resonance (CMR). We sought to validate a novel non-contrast dual energy computed tomography (DECT) method to estimate myocardial fibrosis in patients undergoing CMR with contrast.
Methods: All subjects underwent non-contrast, prospectively-triggered cardiac DECT on a single source scanner with interleaved acquisition between tube voltages of 80 and 140 kVp.
Non-contrast estimation of diffuse myocardial fibrosis with dual energy CT: A phantom study.
J Cardiovasc Comput Tomogr
August 2018
The Ohio State University Davis Heart and Lung Research Institute, 473 W. 12th Ave, Columbus, OH 43210, USA. Electronic address:
Background: Estimation of diffuse myocardial fibrosis, substrate for adverse events such as heart failure and arrhythmias in patients with various cardiac disorders, is presently done by histopathology or cardiac magnetic resonance. We sought to develop a non-contrast method to estimate the amount of diffuse myocardial fibrosis leveraging dual energy computed tomography (DECT) in phantoms and a suitable small animal model.
Methods And Results: Phantoms consisted of homogenized bovine myocardium with varying amounts of Type 1 collagen.
Multiorgan, Multimodality Imaging in Cardiometabolic Disease.
Circ Cardiovasc Imaging
November 2017
From the Ohio State University Davis Heart and Lung Research Institute, Columbus (V.K., W.A.H., S.V.R.); and Division of Endocrinology, Diabetes & Metabolism, Ohio State University, Columbus (W.A.H.).
Cardiometabolic disease, spanning conditions such as obesity to type 2 diabetes mellitus with excess cardiovascular risk, represents a major public health burden. Advances in preclinical translational science point to potential targets across multiple organ systems for early intervention to improve cardiometabolic health. Validation in clinical trials and translation to care would benefit from in vivo diagnostic techniques that facilitate therapeutic advancements.
View Article and Find Full Text PDFRisk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women.
Circ Heart Fail
October 2016
From the Center of Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket (C.B.E., A.Q.); School of Public Health, Alpert Medical School, Brown University, Providence, RI (C.B.E., S.L.); Fred Hutchinson Cancer Research Center, Seattle, WA (M.P.); Women's Health Initiative Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.R.); George Washington University School of Medicine and Health Sciences, Washington, DC (L.W.M.); Division of Epidemiology, College of Public Health, The Ohio State University Columbus (R.F.); The University of Arizona Cancer Center, Phoenix, AZ (N.S.W.); Providence VA Medical Center, RI (W.-C.H.W.); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.E.M.); HealthPartners Institute for Research and Education, Minneapolis, MN (K.M.); University of Tennessee Health Science Center, Memphis, TN (K.C.J.); University of California San Diego (M.A.); The University of North Carolina, Chapel Hill (G.C.-S., W.R.); The Ohio State University Wexner Medical Center, Columbus (K.B.); The Ohio State University Davis Heart and Lung Research Institute, Columbus (K.B.); and University of California San Francisco (L.K.).
Background: Heart failure is an important and growing public health problem in women. Risk factors for incident hospitalized heart failure with preserved ejection fraction (HFpEF) compared with heart failure with reduced ejection fraction (HFrEF) in women and differences by race/ethnicity are not well characterized.
Methods And Results: We prospectively evaluated the risk factors for incident hospitalized HFpEF and HFrEF in a multiracial cohort of 42 170 postmenopausal women followed up for a mean of 13.
Computation of Calcium Score With Dual-Energy Computed Tomography: A Phantom Study.
J Comput Assist Tomogr
January 2017
From the Ohio State University Davis Heart and Lung Research Institute, Columbus, OH; †Department of Radiology, Weill Cornell Medical College, Dalio Institute of Cardiovascular Imaging, New York, NY; ‡Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, College Park, MD; and §The Ohio State University Davis Heart and Lung Research Institute, Columbus, OH.
Dual-energy computed tomography (DECT) improves material and tissue characterization compared with single-energy CT; we sought to validate coronary calcium quantification in advancing cardiovascular DECT. In an anthropomorphic phantom, agreement between measurements was excellent, and Bland-Altman analysis demonstrated minimal bias. Compared with the known calcium mass for each phantom, calcium mass by DECT was highly accurate.
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