2 results match your criteria: "The No.3 Hospital of Wuhan[Affiliation]"

Objective: To investigate the influence of vascular endothelial growth factor (VEGF) gene modification on skin substitute grafted on nude mice.

Methods: Human fibroblasts were transfected with VEGF adenovirus vector. Then the genetic modified fibroblasts were seeded on patches of Integra artificial skin.

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Objective: To observe the revascularization process and histological changes in the dermal substitutes after grafting.

Methods: Twenty-one SD rats were enrolled in the study and were randomly divided into swine acellular dermal matrix (sADM), human acellular dermal matrix (hADM), and artificial dermal equivalent (Integra) groups according to different dermal substitutes grafted underneath the skin of SD rats. The gross appearance of the grafts was observed, and the tissue biopsies were harvested at 2, 3, 4, 7, 10, 14, 21, 30, 60, 90, 120, 150, 180 post grafting day (PGD) for the observation of the revascularization process and their histological changes.

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