[Effect of saffor (Carthamus tinctorius) injection on renal ischemia/reperfusion injury in rats].

Objective: To study the effect and mechanism of saffor injection on renal ischemia/reperfusion (I/R) injury in rats.

Method: Seventy-five SD rats were randomly divided into five groups (n = 15, in each), normal control groups, I/R control groups, low-dose treatment groups, middle-dose treatment groups and high-dose treatment groups. After rat's I/R injury model was established, renal function was assessed by measuring serum creatinine, blood urea nitrogen, urine osmotic pressure and urine osmotic pressure/blood osmotic pressure, the apoptosis rate in I/R renal tissure was measured by TUNEL method and caspase-3 concentration was measured by immunohistochemistry.