Solanum pubescens Wild Fruits Essential Oil - A Golden Casket for its Antimicrobial and Anti-inflammatory Mediated Wound Healing Efficacy in Vertebrate Model Mus musculus.

Background: Solanum pubescens Willd, growing wild in the hills of Rayadurg jurisdiction of Southwestern Andhra Pradesh, has gained significant attention among researchers for its diverse folkloric applications, existence of novel phytochemicals and leaf extracts which hold great medicinal promises. To date, the S. pubescens fruit's essential oil (SPO) has never been investigated.

Gross beta and alpha activities in the selected commercial freshwater fish species in Vietnam.

The baseline data of radioactivity levels in food is one of the main factors for the assessment of resident's health risk. Gross beta and alpha activity was identified for selected commercial freshwater fish species, including 29 types of fish species by a gas-flow proportional detector. The samples were collected from wholesale markets in Hanoi city, Vietnam.

Sublethal Effects of Arsenic on Oxygen Consumption, Hematological and Gill Histopathological Indices in .

Background: The current study was performed aiming to evaluate possible changes in the effect on oxygen consumption, hematology and gill histopathological parameters in fish () upon exposure to sublethal concentration of the metalloid arsenic.

Methods: Bioassay tests were conducted for determining the LC values of arsenic for 96 h. Oxygen consumption in control and arsenic-exposed fish was estimated using Winkler's method.

Investigating fish contamination scenario and community willingness to adopt consumption advice proposing an advisory option.

Consumption advice to ensure the health and safety of fish consumers remains urgent to handle the ever-increasing panic over heavy metal toxicity. Moreover, studies of fish consumption rarely focus on the perceptions and awareness of consumers. Considering this, the present study examines the factors determining the willingness to follow fish consumption advice as well as calculate the risk-benefit ratio and produce the vulnerability map followed by formulating fish consumption advice for consumers of two commercially important fish species, tilapia (Oreochromis niloticus) and mudfish (Ophiocephalus striatus), in the Laguna de Bay area of the Philippines.

Assessment of seasonal variation in distribution and abundance of plankton and ichthyofaunal diversity in relation to environmental indices of Karankadu Mangrove, South East Coast of India.

Karankadu mangrove situated along the Southeast coast of India is known for its unique and extreme species diversity and richness. Ecological functions of this mangrove comprise of nutrient cycling, coastal protection, fish fauna production and carbon sequestration besides providing livelihood to nearby coastal communities. The current study having assessed seasonal fluctuations of various Physico-chemical factors viz.

Radio-protective efficacy of on gamma (Co) irradiation.

Purpose: Freshwater fish was used in this study as a vertebrate model. We evaluated the induction of certain antioxidant enzymes in various vital organs. The radioprotective efficacy of leaves extract (GS) [25mg/kg Body Weight (B.

Impact of Hygrophila auriculata supplementary diets on the growth, survival, biochemical and haematological parameters in fingerlings of freshwater fish Cirrhinus mrigala (Hamilton, 1822).

The present study investigates the effects of Supplementary diet Hygrophila auriculata on the growth, survival, biochemical and haematological parameters of Cirrhinus mrigala. The seaweed was administered to the fish possessing an initial average weight of 14.063 ± 1.

Seasonal changes in the milt quality of spotted scat, Scatophagus argus: Implications for artificial propagation.

The current study investigated the correlation among sperm production (milt volume, spermatocrit and sperm count), sperm motility characters and biochemical composition of seminal plasma during different seasons to estimate the quality of semen in the Spotted scat (Scatophagus argus). The sperm of 120 males were collected over a period of 2 years seasonally viz., summer, pre-monsoon, monsoon and post-monsoon.

Structure, morphology and modelling studies of polyvinylalcohol nanocomposites reinforced with nickel oxide nanoparticles and graphene quantum dots.

Nickel oxide (NiO) nanoparticles (NPs) and graphene quantum dots (GQDs) reinforced polyvinyl alcohol (PVA) nanocomposite films were prepared using a solution casting technique. The physicochemical characteristics of PVA/NiO/GQDs (PNG) nanocomposite films were studied using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and field emission scanning electron microscopy (FESEM). The obtained PNG nanocomposite films showed good mechanical flexibility and improved tensile strength.

Antioxidant and antigenotoxic potential of Morinda tinctoria Roxb. leaf extract succeeding cadmium exposure in Asian catfish, Pangasius sutchi.

The present study investigated the protective effect of methanolic leaf extract of Morinda tinctoria. Roxb (MEMT) (200 mg/kg) via feed in supplementation with standard compound silymarin (400 mg/kg). M.

Modulation of growth, innate immunity, and disease resistance of Nile tilapia (Oreochromis niloticus) culture under biofloc system by supplementing pineapple peel powder and Lactobacillus plantarum.

Eight weeks feeding experiment was managed to evaluate the impacts of dietary addition of pineapple peel powder (PAPP) and Lactobacillus plantarum CR1T5 (LP) individual or mixed on growth performance, skin mucus and serum immunities, as well as disease resistance of Nile tilapia. Fish (average weight 20.91 ± 0.

Uranium induces genomic instability and slows cell cycle progression in human lymphocytes in acute toxicity study.

In the situation of radiation triage, accidental exposure to uranium, or uranium contamination in food or water; haematopoietic decline or bone marrow sickness is observed in the aftermath followed by other systemic effects. Most studies done previously have been on cytogenetic analysis in blood lymphocytes of uranium miners wherein causal relationship was difficult to be established. This study provides new insights into the minimum risk level of uranium to human lymphocytes, DNA damage induced and alterations in the cell cycle progression through 96-h acute toxicity study.

Effect of Pore Connectivity on the Behavior of Fluids Confined in Sub-Nanometer Pores: Ethane and CO Confined in ZSM-22.

The behavior of fluids under nano-confinement varies from that in bulk due to an interplay of several factors including pore connectivity. In this work, we use molecular dynamics simulations to study the behavior of two fluids-ethane and CO confined in ZSM-22, a zeolite with channel-like pores of diameter 0.55 nm isolated from each other.

Sublethal effects of phenol on histology of selected organs of freshwater fish Mystus vittatus.

Acute toxicity (96 h LC) of phenol was analyzed in the cat fish Mystus vittatus in static bio-assay over a 96-h exposure period using probit method. The 24, 48, 72, and 96 h LC values (with 95% confidence limits) of phenol for fingerling catfish were found out as 13.98, 13.

Silver(I) metallodrugs of thiosemicarbazones and naproxen: biocompatibility, anti-proliferative activity and interaction studies with EGFR, VEGFR2 and LOX receptors.

Four new heteroleptic silver(I) complexes with the general formula [Ag(L)(nap)] (-), where L =  2-(1-(4-substitutedphenyl)ethylidene)hydrazinecarbothioamide and nap = naproxen, have been synthesized and characterized. The geometric parameters determined from density functional theory and UV-Vis studies indicate distorted tetrahedral geometry around silver(I) ion. Fourier transform infrared (FT IR) spectra evidenced asymmetric bidentate coordination mode of carboxyl oxygen atoms of naproxen with silver(I) ion.

The crystal structures and Hirshfeld surface analysis of 6-(naphthalen-1-yl)-6a-nitro-6,6a,6b,7,9,11a-hexa-hydro-spiro-[chromeno[3',4':3,4]pyrrolo-[1,2-]thia-zole-11,11'-indeno-[1,2-]quinoxaline] and 6'-(naphthalen-1-yl)-6a'-nitro-6',6a',6b',7',8',9',10',12a'-octa-hydro-2-spiro-[ace-naphthyl-ene-1,12'-chromeno[3,4-]indolizin]-2-one.

The title compounds, 6-(naphthalen-1-yl)-6a-nitro-6,6a,6 b,7,9,11-hexa-hydro-spiro-[chromeno[3',4':3,4]pyrrolo-[1,2-]thia-zole-11,11'-indeno-[1,2-]quinoxaline], CHNOS, (I), and 6'-(naphthalen-1-yl)-6a'-nitro-6',6a',6b',7',8',9',10',12'-octa-hydro-2-spiro-[ace-naphthyl-ene-1,12'-chromeno[3,4-]indolizin]-2-one, CHNO, (II), are new spiro derivatives, in which both the pyrrolidine rings adopt twisted conformations. In (I), the five-membered thia-zole ring adopts an envelope conformation, while the eight-membered pyrrolidine-thia-zole ring adopts a boat conformation. An intra-molecular C-H⋯N hydrogen bond occurs, involving a C atom of the pyran ring and an N atom of the pyrazine ring.

The crystal structures and Hirshfeld surface analyses of four 3,5-diacetyl-2-methyl-2,3-di-hydro-1,3,4-thia-diazol-2-yl derivatives.

The title compounds, 4-(5-acetamido-3-acetyl-2-methyl-2,3-di-hydro-1,3,4-thia-diazol-2-yl)phenyl benzoate, CHNOS (), 4-(5-acetamido-3-acetyl-2-methyl-2,3-di-hydro-1,3,4-thia-diazol-2-yl)phenyl isobutyrate 0.25-hydrate, CHNOS·0.25HO (), 4-(5-acetamido-3-acetyl-2-methyl-2,3-di-hydro-1,3,4-thia-diazol-2-yl)phenyl propionate, CHNOS () and 4-(5-acetamido-3-acetyl-2-methyl-2,3-di-hydro-1,3,4-thia-diazol-2-yl)phenyl cinnamate chloro-form hemisolvate, CHNOS·0.

Crystal structure and Hirshfeld surface analysis of 2-[(2-oxo-2-chromen-4-yl)-oxy]acetic acid dimethyl sulfoxide monosolvate.

The title compound, CHO·(CH)SO, is a new coumarin derivative. The asymmetric unit contains two coumarin mol-ecules ( and ) and two di-methyl-sulfoxide solvent mol-ecules ( and ). The dihedral angle between the pyran and benzene rings in the chromene moiety is 3.

Crystal structures of two new isocoumarin derivatives: 8-amino-6-methyl-3,4-diphenyl-1-isochromen-1-one and 8-amino-3,4-diethyl-6-methyl-1-isochromen-1-one.

The title compounds, 8-amino-6-methyl-3,4-diphenyl-1-isochromen-1-one, CHNO, (I), and 8-amino-3,4-diethyl-6-methyl-1-isochromen-1-one, CHNO, (II), are new isocoumarin derivatives in which the isochromene ring systems are planar. Compound II crystallizes with two independent mol-ecules ( and ) in the asymmetric unit. In I, the two phenyl rings are inclined to each other by 56.

Biocompatibility, Antiproliferative, and EGFR/VEGFR2 Studies of Heteroleptic Metal(II) Complexes of Thiosemicarbazones and Naproxen.

Eight heteroleptic nickel(II) and copper(II) complexes of the type [M(L)(nap)] (-), where L = 2-(1-(4-substitutedphenyl)ethylidene)hydrazinecarbothioamide, nap = naproxen, and M = Ni(II) or Cu(II), have been synthesized and characterized. UV-vis and EPR spectral studies showed distorted octahedral geometry around metal(II) ions. The cyclic voltammogram of complexes - displayed an irreversible one-electron transfer process in the cathodic region ( = -0.

The crystal structures of two new coumarin derivatives: 2-(4-{2-[(2-oxo-2-chromen-4-yl)-oxy]acet-yl}piperazin-1-yl)acetamide and -(2,4-di-meth-oxy-benz-yl)-2-[(2-oxo-2-chromen-4-yl)-oxy]acetamide.

The title compounds, 2-(4-{2-[(2-oxo-2-chromen-4-yl)-oxy]acet-yl}piperazin-1-yl)acetamide, CHNO, (I), and -(2,4-di-meth-oxy-benz-yl)-2-[(2-oxo-2-chromen-4-yl)-oxy]acetamide, CHNO, (II), are new coumarin derivatives. In compound (I), the six-membered piperazine adopts a chair conformation. The dihedral angles between the mean planes of the chromene ring and amide plane is 82.

The crystal structures and Hirshfeld surface analysis of ','''-((1,1')-{[methyl-enebis(-oxy)]bis-(6-bromo-3,1-phenyl-ene)}bis-(methan-ylyl-idene))bis-(isonicotinohydrazide) dihydrate and ','''-((1,1')-{[butane-1,4-diylbis(-oxy)]bis-(2,1-phenyl-ene)}bis-(methan-ylyl-idene))bis-(isonicotino-hydrazide) [+ solvent].

The title compounds, CHBrNO·2HO, (I), and CHNO·[+ solvent], (II), both crystallize with one half-mol-ecule in the asymmetric unit. The whole mol-ecule of (I) is generated by twofold rotation symmetry, with the twofold rotation axis bis-ecting the C atom of the -O-CH-O- bridge. This results in a folded or U-shaped conformation of the mol-ecule.

DNA profiling and in vitro cytotoxicity studies of tetrazolo[1,5-a]pyrimidine-based copper(II) complexes.

A series of N-benzoylated mononuclear copper(II) complexes of the type [Cu(L)Cl] (1-6), where L= ethyl 4-benzoyl-5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, L= ethyl 4-(4-nitrobenzoyl)-5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, L = ethyl 4-benzoyl-5-methyl-7-(4-methoxyphenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, L = ethyl 4-(4-nitrobenzoyl)-5-methyl-7-(4-methoxyphenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, L = ethyl 4-benzoyl-5-methyl-7-(4-chlorophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate and L = ethyl 4-(4-nitrobenzoyl)-5-methyl-7-(4-chlorophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate have been synthesized and characterized by spectral methods. Electron paramagnetic resonance spectra of complexes show four lines, characteristic of square planar geometry. The binding studies of the complexes with calf thymus DNA (CT-DNA) revealed groove mode of binding, which were further supported by molecular docking studies.