2 results match your criteria: "The Netherlands. p.vulto@lacdr.leidenuniv.nl[Affiliation]"
Phaseguides as tunable passive microvalves for liquid routing in complex microfluidic networks.
Lab Chip
September 2014
Division for Analytical Biosciences, Leiden Academic Centre for Drug Research, University of Leiden, 2300 RA, Leiden, The Netherlands.
A microfluidic passive valving platform is introduced that has full control over the stability of each valve. The concept is based on phaseguides, which are small ridges at the bottom of a channel acting as pinning barriers. It is shown that the angle between the phaseguide and the channel sidewall is a measure of the stability of the phaseguide.
View Article and Find Full Text PDFBubble-free electrode actuation for micro-preparative scale electrophoresis of RNA.
Lab Chip
August 2013
Leiden Academic Centre for Drug Research (LACDR), Division of Analytical Biosciences, Leiden University, Einsteinweg 55, 2333CC, Leiden, The Netherlands.
Article Synopsis
- A microfluidic chip is designed for efficient lysis and purification of RNA from bacteria using joule-heating and gel electrophoresis.
- Silver chloride electrodes help prevent bubble formation during electrophoresis and maintain solution clarity by using saturated chloride for the anode.
- The technology was validated by successfully extracting and amplifying transfer-messenger RNA from E. coli, paving the way for advanced, miniaturized diagnostic tools.