2 results match your criteria: "The Netherlands. m.d.klok@lacdr.leidenuniv.nl[Affiliation]"
Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder.
J Psychiatr Res
July 2011
Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Appropriate signaling in the brain by the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) is critical in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, emotional arousal and cognitive performance. To date, few data exist on MR (and GR) expression in the brain of patients suffering from major depressive disorder (MDD). With the help of quantitative PCR we assessed MR and GR mRNA expression, including the splice variants MRα and MRβ, in tissue samples from the hippocampus, amygdala, inferior frontal gyrus, cingulate gyrus and nucleus accumbens.
View Article and Find Full Text PDFCommon functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs.
Psychoneuroendocrinology
May 2011
Department of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Article Synopsis
- The study investigates how genetic variations in the mineralocorticoid receptor (MR) influence the cortisol awakening response (CAR) in patients with major depressive disorder (MDD), particularly focusing on women.
- These variations include common single nucleotide polymorphisms (SNPs), specifically MR -2G/C and I180V, and findings suggest that the MR -2C/C genotype is linked to a reduced CAR in women, especially when they are using selective serotonin reuptake inhibitors (SSRIs).
- The results indicate an interaction between MR genotype and SSRI usage, highlighting that genetic factors may influence how individuals respond to treatment, providing insights for personalized approaches in managing depression.