2 results match your criteria: "The Netherlands. lyzel.elias@maastrichtuniversity.nl[Affiliation]"

Relationship between genetic risk factors and markers for Alzheimer's disease pathology.

Biomark Med

August 2012

School for Mental Health & Neuroscience, Alzheimer Centrum Limburg, Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, The Netherlands.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuritic plaques (main constituent: β-amyloid [Aβ]) and neurofibrillary tangles (hyperphosphorylated tau protein) in the brain. Abnormalities in Aβ and tau can be measured upon neuropathological examination, in cerebrospinal fluid or by PET. Etiologically, a growing body of evidence suggests that susceptibility to AD is genetically controlled.

View Article and Find Full Text PDF

Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis.

J Neurol Neurosurg Psychiatry

October 2011

School of Mental Health and Neuroscience, Alzheimer Center Limburg, Department of Psychiatry and Neuropsychology, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: The identification of subjects with mild cognitive impairment (MCI) at high risk for Alzheimer's disease (AD) is important for prognosis and early intervention. The APOE-ε4 allele is the strongest known genetic risk factor for AD. The authors performed a meta-analysis to establish the predictive accuracy of the APOE-ε4 allele for progression from MCI to AD-type dementia.

View Article and Find Full Text PDF