Hippocampal volume and internalizing behavior problems in adolescence.

Adolescence is characterized by dynamic changes in structural brain maturation. At the same time, adolescence is a critical time for the development of affective and anxiety-related disorders. Individual differences in typically developing children and adolescents may prove more valuable for identifying which brain regions correspond with internalizing behavior problems (i.

A three-year longitudinal functional magnetic resonance imaging study of performance monitoring and test-retest reliability from childhood to early adulthood.

Previous cross-sectional functional magnetic resonance imaging studies have shown that performance monitoring functions continue to develop well into adolescence, associated with increased activation in brain regions important for cognitive control (prefrontal cortex, anterior cingulate cortex, and parietal cortex). To date, however, the development of performance monitoring has not yet been studied longitudinally, which leaves open the question whether changes can be detected within individuals over time. In the present study, human boys and girls, between ages 8 and 27 years, performed a child-friendly rule-switch task in the scanner on two occasions ∼3.

Hippocampal volume change in schizophrenia.

Objective: Patients with schizophrenia show reductions in hippocampal volume. However, the time course of these changes is still unresolved. The aim of this study is to examine the extent to which hippocampal volume change in patients with schizophrenia is confounded by effects of age and/or antipsychotic medication.

Cortical thickness and voxel-based morphometry in depressed elderly.

This is the first study to examine concurrently cortical thickness and voxel-based morphometric (VBM) abnormalities in patients with major depressive disorder (MDD). In the current study we set out to investigate depressed elderly patients to determine whether a previous depression is related to neurobiological abnormalities in older age. Cortical thickness measures and VBM were applied to the same magnetic resonance imaging data set of 28 female elderly subjects with MDD and 38 age-matched control subjects.