1 results match your criteria: "The Netherlands. h.s.overkleeft@chem.leidenuniv.nl j.m.f.g.aerts@lic.leidenuniv.nl.[Affiliation]"
Development of an acid ceramidase activity-based probe.
Chem Commun (Camb)
April 2015
Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands.
Article Synopsis
- Acid ceramidase breaks down (glyco)sphingolipids by converting ceramide into sphingosine and free fatty acids.
- A lack of acid ceramidase leads to Farber disease, which is linked to this enzyme's deficiency.
- The study introduces a new probe designed to investigate and measure the activity of acid ceramidase.