3 results match your criteria: "The Netherlands. Kooten@mail.Medfac.LeidenUniv.nl[Affiliation]"
Exp Nephrol
May 2001
Department of Nephrology, Leiden University Medical Center, Leiden, The
Tubulo-interstitial inflammation in the kidney is characterized by the presence of activated T cells. Both by the local production of cytokines, as well as by direct cell-cell interactions, these activated T cells might affect the immune and inflammatory response. Recently it has been demonstrated that these kidney-infiltrating T cells express CD40 ligand and that tubular epithelial cells (TECs) express CD40.
View Article and Find Full Text PDFJ Leukoc Biol
January 2000
Department of Nephrology, Leiden University Medical Center, The Netherlands.
CD40 is a cell surface receptor that belongs to the tumor necrosis factor-R (TNF-R) family, and that was first identified and functionally characterized on B lymphocytes. Its critical role in T cell-dependent humoral immune responses was demonstrated by patients with the hyper-IgM syndrome, as well as by gene targeting in mice. However, in recent years it has become clear that CD40 is expressed much more broadly, including expression on monocytes, dendritic cells, endothelial cells, and epithelial cells.
View Article and Find Full Text PDFCurr Opin Nephrol Hypertens
November 1999
Department of Nephrology, Leiden University Medical Center, The Netherlands.
Understanding of how antigen-specific signals and costimulatory molecules are involved in T-cell activation has resulted in new strategies to interfere with allograft rejection. The present review focuses on the role of two receptor-ligand pairs: CD28 and cytotoxic T lymphocyte associated antigen-4, which interact with the B7 ligands (CD80, CD86); and CD40, which interacts with the CD40L (CD154). On the basis of the extensive tissue distribution of CD40, it is likely that the CD40/CD40L system plays a much broader role.
View Article and Find Full Text PDF