1 results match your criteria: "The Netherlands. Electronic address: j.bussmann@lacdr.leidenuniv.nl.[Affiliation]"
Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles.
Nanomedicine
June 2021
Department of Supramolecular & Biomaterials Chemistry, Leiden Institute of Chemistry (LIC), Leiden University, RA, Leiden, The Netherlands; Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, RA, Leiden, The Netherlands. Electronic address:
Clearance of nanoparticles (NPs) after intravenous injection - mainly by the liver - is a critical barrier for the clinical translation of nanomaterials. Physicochemical properties of NPs are known to influence their distribution through cell-specific interactions; however, the molecular mechanisms responsible for liver cellular NP uptake are poorly understood. Liver sinusoidal endothelial cells and Kupffer cells are critical participants in this clearance process.
View Article and Find Full Text PDF