170 results match your criteria: "The Netherlands Cancer Institute Antoni van Leeuwenhoek Huis[Affiliation]"
J Pathol
October 1988
Department of Pathology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Microscopically assessed changes observed in large sections of osteosarcomas from patients who had undergone pre-operative chemotherapy (PCT) (n = 22), or no chemotherapy (n = 22), were examined either quantitatively, semiquantitatively, or qualitatively. Eight tumour characteristics were associated with the treatment mode by way of a stepwise logistic analysis. Minimal amount of viable tumour tissue (less than 10 per cent) and strong fibroblastic proliferation were each proved to be associated with PCT.
View Article and Find Full Text PDFCancer Res
October 1988
Division of Chemical Carcinogenesis, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
The formation and stability of interaction products between the anti-cancer drug cis-diamminedichloroplatinum(II) (cis-DDP) and DNA were studied in buccal epithelial and urinary cells from ten cancer patients who received cis-DDP-based therapy. Buccal cells were collected 1 h before and 1-2 h after i.v.
View Article and Find Full Text PDFBiochim Biophys Acta
August 1988
Division of Cellular Biochemistry, The Netherlands Cancer Institute (Antoni van Leeuwenhoek-Huis), Amsterdam.
Mice of the GR/A strain were fed four different isocaloric semipurified diets, enriched in either (1) saturated fatty acids (palm oil), or (2) polyunsaturated fatty acids (corn oil), or (3) palm oil plus cholesterol, or (4) a fat-poor diet containing only a minimal amount of essential fatty acids. We have studied the effects of these dietary lipids on the density profile and composition of the plasma lipoproteins and on the lipid composition and fluidity of (purified) lymphoid cell membranes in healthy mice and in mice bearing a transplanted lymphoid leukemia (GRSL). Tumor development in these mice occurred in the spleen and in ascites.
View Article and Find Full Text PDFEur J Immunol
May 1988
The Netherlands Cancer Institute (Antoni van Leeuwenhoek-Huis), Amsterdam.
The assembly of HLA class I antigens, and the contribution of the single N-linked glycan to this process were examined. We observed a requirement for N-linked glycosylation in the proper assembly and surface expression of HLA-B locus products in particular, although considerable variation was seen within the allelic series of the HLA-A and B loci. We conclude that the single N-linked glycan can contribute in a major way to that conformation of the heavy (H) chain which is competent to associate with the light chain beta 2-microglobulin, and that the presence, rather than the type, of carbohydrate chain is important in this respect.
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of Anaesthesiology/Pain Management Unit, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Perineal pain caused by cancer in the pelvic region is difficult to manage. Systemic narcotics often provide incomplete relief. A patient with perineal pain due to recurrence of a rectal carcinoma successfully treated with repeated intrathecal neurolytic blocks is described.
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of Urology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Cancer of the penis is an uncommon disease in the western world, but it causes significant morbidity and mortality worldwide. Discussions have tended to centre around issues of local tumor control and the functional status of the penis after treatment. Since November 1982 we have treated localized squamous cell penile cancer (Tis, T1 and T2, Classification UICC, Geneva 1978) with the Nd-YAG laser.
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of Gynaecology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Histological material was reviewed from the 213 patients who had undergone radical surgery for carcinoma of the uterine cervix stage I and IIA between 1967 and 1981. Squamous carcinoma was found in 179 patients (84.7%).
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of Surgery, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Twenty-three patients with serious irradiation damage of the rectum underwent surgical treatment. Patients were classified according to the level of the lesion and the presence of stenosis. Patients with high lesions (Type I) (n = 5), were treated by resection with end to end anastomosis.
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of Gynecology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Two local repair procedures, one without (9) and the other with (14) a bulbocavernosus muscle graft were performed on 20 patients with a radiation induced rectovaginal fistula. Four patients had two procedures successively. The initial success rate of both procedures was 7/9 and 14/14 respectively.
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of ENT-Head and Neck Surgery, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Seventy patients surgically treated in The Netherlands Cancer Institute between 1969 and 1984 for cutaneous melanoma of the head and neck were reviewed with regard to patient data, tumor site, stage, histological criteria, treatment, disease-control and survival. The objectives of the study were to analyse the results of curative treatment of cutaneous melanoma of the head and neck, the value of prognostic factors and the treatment policy for the N0 and N+ neck. Tumor thickness (Breslow Index) was by far the most important prognostic factor in cutaneous melanoma of the head and neck.
View Article and Find Full Text PDFThe time course of tissue levels of melphalan during normothermic isolated limb perfusion, and the overall tissue levels per 60 min of perfusion, were estimated from the known pharmacokinetic parameters for a fixed dose of drug per liter of tissue (Benckhuijsen et al., J. Pharmacol Exp Ther 1986; 237: 583-8).
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of Surgery, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
In the period 1977-1983, 183 adult patients with soft tissue sarcomas of the extremities were treated in the Netherlands Cancer Institute. One hundred and seventy-one patients had initially operable tumors. Fifteen patients (8.
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of Social Medicine, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Why are only less than 1% of the mastectomized women in The Netherlands reconstructed? We report the results of four studies, among reconstructed patients and their partners, among women who had an amputation only and among general and plastic surgeons in The Netherlands. In contrast to what is thought by (plastic) surgeons, women do not opt in the first place for breast reconstruction because of emotional or cosmetic reasons, but to be freed from the prosthesis. Surgeons hardly ever take the initiative to inform patients about breast reconstruction.
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Division of Molecular Biology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Amplification of the neu (or c-erbB-2 or HER) oncogene is found to be present in 15-30% of human breast carcinomas and has been reported to correlate with poor prognosis. We briefly review the literature on this subject with emphasis on our own results on immunohistochemical detection of neu overproduction in paraffin embedded tissue sections of human breast carcinomas.
View Article and Find Full Text PDFEur J Surg Oncol
April 1988
Department of Surgery, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Eur J Surg Oncol
April 1988
Department of Surgery, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
Chest wall resection has been carried out in 30 patients with chest wall recurrences of breast cancer after previous mastectomy and irradiation. Patients were carefully selected. Twenty-eight patients were treated with curative intent, two patients underwent palliative resections for extremely painful ulcerating recurrences.
View Article and Find Full Text PDFAm J Pathol
January 1988
Division of Immunology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
A monoclonal antibody, NKI/beteb, was prepared against membranes from a human melanoma metastasis, and in immunoprecipitates of melanoma cell lysates specific 100- and 7-kd glycoproteins were found. The large glycoproteins were also present in conditioned medium of melanoma cell lines. The antigen is located on the inner side of membranes of (pre)melanosomes and premelanosomelike vesicles.
View Article and Find Full Text PDFLipids
November 1987
Division of Cell Biology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek-Huis), Amsterdam.
In our search for the mechanisms by which the drug 1-O-alkyl-2-O-methylglycero-3-phosphocholine (AMG-PC) inhibits tumor growth and metastasis, we have detected a metabolite, 1-O-alkyl-2-O-methylglycerol (AMG), in membranes of MO4 mouse fibrosarcoma cells grown in the presence of the drug. Synthetic AMG inhibited the activation of highly purified human protein kinase C by diacylglycerol in the presence of phosphatidylserine. Furthermore, AMG also inhibited the receptor-specific binding of 3H-phorbol-12,13-dibutyrate to human HL-60 promyeloid leukemia cells in a dose-dependent fashion.
View Article and Find Full Text PDFBr J Radiol
October 1987
Department of Experimental Radiotherapy, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
J Cell Sci
October 1987
Division of Cell Biology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.
The interaction of H-2 antigens and plasma membrane-associated filaments was studied on dry-cleaved preparations of immunogold-labelled lymphoma cells. In prefixed cells, the plasma membrane-associated network was isotropic without any prevailing direction of the filaments, and the gold-labelled H-2 antigens were preferentially localized over or at a very short distance from membrane-associated filaments. Incubation of unfixed cells with anti-H-2 antibodies followed by fixation and incubation with anti-Ig, did not induce detectable redistribution of H-2 antigens or of the filament network.
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