Clinical Manifestations.

Background: Sporadic bvFTD is often misdiagnosed as a primary psychiatric disorder (PPD) due to overlapping clinical features and lack of reliable biomarkers. The multi-centre study DIPPA-FTD aims to develop diagnostic- and prognostic-algorithms that can distinguish sporadic bvFTD from late-onset PPD. The aim of the retrospective DIPPA-FTD study was to identify the strongest clinical discriminators.

Missing data and long-term outcomes from nutrition research in the critically ill.

Purpose Of Review: The use of functional outcomes in critical care nutrition research is increasingly advocated; however, this inevitably gives rise to missing data. Consequently there is a need to adopt modern approaches to the foreseeable problem of missing functional and survival outcomes in research trials.

Recent Findings: Analyses that ignore unobserved or missing data will often return biased effect estimates.

Clinical Manifestations.

Background: Young onset dementia (YOD) is characterized by an atypical clinical manifestation, and it is unclear to what extent impairments in everyday functioning are part of this manifestation. This study aims to describe the prevalence and differences of difficulties in instrumental activities of daily living (IADL) in YOD.

Methods: In this cross-sectional study, 394 subjects with sporadic YOD (onset<65 years,mean(M)age 58.

Clinical Manifestations.

Background: Worldwide, 32 million Alzheimer's disease (AD) patients contribute to a large economic burden, making effective and safe therapies that slow or prevent the progression from pre-dementia or mild cognitive impairment (MCI) to AD of high priority. Transcranial alternating current stimulation (tACS) is a safe and patient-friendly non-invasive brain stimulation technique that serves as a potential candidate for slowing and/or reducing cognitive impairment. Application of tACS in the gamma (30-45 Hz) frequency range, specifically around 40 Hz, has been studied in patients with (pre-dementia) AD.

Clinical Manifestations.

Background: It remains unclear to what extent global cognition translates to everyday functioning, although this is essential to interpreting the clinical meaningfulness of cognitive deficits. Here, we investigate potential linking between the Mini-Mental State Examination (MMSE) and the proxy-based Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q).

Methods: Cross-sectional data from 1228 amyloid-positive participants (age = 64±7yrs; 51.

Prevalence and risk factors of antibiotic resistance for urinary tract infections in patients presenting to a Belgian tertiary care emergency department: testing the national guidelines against the local setting.

Objectives: Urinary tract infections (UTIs) are an important cause of empiric antibiotic (over)treatment at the emergency department (ED). To enhance empiric antibiotic choices, mapping the national and local microbiology and antimicrobial resistance (AMR) patterns is crucial. This study aims to examine resistance patterns at a Brussels ED and to identify risk factors for AMR to evaluate current treatment guidelines and help combat AMR.

Impact of Synchronized Radiofrequency and High-Intensity Facial Electrical Stimulation on Facial Muscles and the Superficial Fascial System in the Midface.

Background: Midfacial aging involves skeletal changes, muscle weakening, and fat redistribution, resulting in volume loss, skin sagging, and deepened nasolabial folds. High-Intensity Facial Electrical Stimulation (HIFES) combined with Radiofrequency (RF) is a novel non-invasive method to address these changes by enhancing muscle mass and remodeling subcutaneous tissue.

Objectives: To assess the efficacy of HIFES and Synchronized RF in improving midfacial aesthetics, specifically muscle thickness, skin displacement, and facial volume.

Global, regional, and national burden of primary liver cancer attributable to metabolic risks: an analysis of the Global Burden of Disease Study 1990-2021.

Background: The global burden of metabolic diseases is increasing, but estimates of their impact on primary liver cancer are uncertain. We aimed to assess the global burden of primary liver cancer attributable to metabolic risk factors, including high body mass index (BMI) and high fasting plasma glucose (FPG) levels, between 1990 and 2021.

Methods: The total number and age-standardized rates of deaths and disability-adjusted life years (DALYs) from primary liver cancer attributable to each metabolic risk factor were extracted from the Global Burden of Disease Study 1990-2021.

Factors Associated With Prelacteal Feeding of Commercial Milk Formula: An Analysis of Cohort Data From the BADUTA Study in Indonesia.

Introducing commercial milk formula (CMF) as prelacteal feeds can disturb exclusive breastfeeding and shorten breastfeeding duration. However, the prelacteal feeding of CMF has been growing alongside its increasing sales in Indonesia. This study examined predictors of the CMF feeding in the Malang and Sidoarjo districts of Indonesia.

Fight or Flight: Emergency Health Care Workers' Willingness to Work during Crises and Disasters. A Cross-Sectional Multicenter Study in the Netherlands.

Objective: Expanding staff levels is a strategy for hospitals to increase their surge capacity. The aim of this study was to evaluate whether emergency health care workers (HCWs) are willing to work during crises or disasters, and which working conditions influence their decisions.

Methods: HCWs in the emergency departments (EDs) and intensive care units (ICUs) of 5 Dutch hospitals were surveyed about various disaster scenarios.

Major Internal Fires in Dutch Hospitals: A Scoping Review.

Objectives: Fires are among the most feared incidents that can occur in a hospital. Hospital fires will disrupt care continuity, may require the evacuation of patients and have the potential to result in injuries or even deaths. The aim of this study is to gain insight into hospital fires in the Netherlands over a 20-year period.

Phenotype Spectrum of TRPM3-Associated Disorders.

Objective: Monoallelic variants in the transient receptor potential melastatin-related type 3 gene (TRPM3) have been associated with neurodevelopmental manifestations, but knowledge on the clinical manifestations and treatment options is limited. We characterized the clinical spectrum, highlighting particularly the epilepsy phenotype, and the effect of treatments.

Methods: We analyzed retrospectively the phenotypes and genotypes of 43 individuals with TRPM3 variants, acquired from GeneMatcher and collaborations (n = 21), and through a systematic literature search (n = 22).

Emerging Antifungal Resistance in : Insights from Susceptibility Profiling and Genetic Mutation Analysis.

species, the leading cause of dermatophytosis globally, are increasingly resistant to antifungal treatments, concerns about effective management strategies. In light of the absence of established resistance criteria for terbinafine and azoles, coupled with a dearth of research on resistance mechanisms in , antifungal susceptibility and drug resistance gene diversity were analyzed across 64 , 65 , and 2  isolates collected in China between 2001 and 2024 and 101 published strains. Analyses of the minimum inhibitory concentrations (MICs) of terbinafine, itraconazole, voriconazole, posaconazole, and isavuconazole revealed a concerning increase in with terbinafine resistance, including two novel isolates from China.

[The Open-Doors Policy in Oslo: both the starting point and the final chord].

Background: The Lovisenberg Diakonal Hospital recently introduced an Open-Door Policy in their (formerly) closed psychiatric admission wards for people with a forced admission to an acute psychiatric crisis. Their modern mental health care system is remarkably similar to the Dutch healthcare organization, with shared values and standards, and provides good grounds for an implementation of an Open-Doors Policy in the Netherlands.

Aim: Gaining inspiration to reduce seclusion and create a new quality development and assessment process for closed admission departments in the Dutch mental health care system.

[Barriers for including sufficient participants in multi-center drug research].

Background: The SPACe 2: STAR trial is a multicenter trial in children with an autism spectrum disorder, divided over nine centers in the Netherlands. However, it is challenging to include enough participants due to various factors, including the varying status of the disorder and willingness of parents and children.

Aim: To identify and overcome the bottlenecks for practitioners during the trial to prevent major delays.

[Social media restriction: caselaw from the new Dutch Compulsory Mental Healthcare Act].

Background: Patients use social media on a daily basis, and they can be restricted under the new Dutch Compulsory Mental Healthcare Act.

Aim: To describe which social media behaviors of psychiatric patients were rightfully restricted by health care professionals and reveal underlying reasons.

Method: We searched for law cases of the courts of first instance and decisions of boards on patients’ complaints from implementation of the new act (2020-2023) about patients’ behaviors related to social media in two open source databases.

A surrogate ELISA to select high titer human convalescent plasma for treating immunocompromised patients infected with SARS-CoV-2 variants of concern.

Background: The emergence of new SARS-CoV-2 variants poses a new challenge for the treatment of immunocompromised patients against COVID-19. In this context, high titer COVID-19 Convalescent Plasma (CCP) is one of the few available therapeutics for these patients. We have revisited the selection of CCP samples and its efficacy against Omicron XBB.

Challenges and strategies for effective recruitment and retention of participants in clinical research studies.

Effective recruitment and retention of participants in clinical research studies are critical to be able to draw meaningful and valid conclusions in research studies. However, there are multiple challenges related to communication, generalizability, and logistics. Researchers must address and overcome these challenges to ensure robust research outcomes.

From Straight Lines to Twists and Turns: Finding Patterns Between Socio-Economics and Unequal Health Outcomes in the Life Course.

Despite welfare state expansion in liberal democracies during the 20th century, health inequalities between socio-economic groups persist. Understanding individuals' lived experiences can inform policy for reducing unequal health outcomes in these lives. We build on Fundamental Cause Theory (FCT), which posits that low socio-economic status is the fundamental cause of health problems in (later) life.

Patients perspectives on integrating eHealth in regular care pathways for atrial fibrillation: evaluating photoplethysmography for remote self-assessment.

Aims: Smartphone applications for heart rate and rhythm assessment are increasingly used for the management of atrial fibrillation (AF). Although the use of a photoplethysmography (PPG)-based smartphone application with subsequent (tele)consultations for AF management has been proven feasible in the TeleCheck-AF project, specific needs, and expectations of patients with AF are unclear. The aim of this study is to evaluate patients' perspectives on the use of remote PPG-based electronical health (eHealth) integrated in regular care pathways for AF.

Examining Psychosis Risk in Sexual Minority Youth: Increased Exposure to and Differential Impact of the Social Envirome in Early Adolescence.

Background And Hypotheses: Sexual minority populations have a higher prevalence of psychotic experiences (PE), possibly due to differential experiences within the social envirome in its positive (eg, social support, parenting) and negative aspects (eg, adverse life events, bullying). This study hypothesized that (1) sexual minority adolescents experience more PE, (2) are more exposed to harmful aspects of the social envirome, and (3) may display differential sensitivity to certain aspects of the social envirome.

Study Design: Data from 678 adolescents (mean age 15.

Platelets and monocytes: A dynamic duo aiding in the prediction of the clinical response to thrombopoietin receptor agonists in immune thrombocytopenia?

Patients with immune thrombocytopenia (ITP) suffer from an autoimmune bleeding disorder with an isolated low number of platelets. Platelets and megakaryocytes are targeted by the immune system, due to a loss of immune tolerance, via the action of platelet-autoantibodies and/or cytotoxic T cells. ITP is a highly variable disorder regarding the underlying biological mechanisms, disease trajectories and treatment responses.

Why we need a representative organization of academic PRM in Europe, and why we need it now.

The growing relevance of rehabilitation in healthcare to address increasing patient needs necessitates robust Physical and Rehabilitation Medicine (PRM) integration into medical education and practice. Academic PRM, rooted in medical faculties, is vital for developing the medical speciality as an academic discipline across Europe, where it faces challenges, including limited representation in medical schools and competition for resources with established disciplines. This commentary advocates establishing a representative organization for academic PRM in Europe.

Ethnicity and health-related quality of life in the post stroke population: a systematic review.

Background/objective: A systematic review was conducted on the association between ethnicity and health-related quality of life in post-stroke populations.

Methods: In February 2024, a comprehensive search was conducted across several databases. Studies were included when they had at least 2 distinct ethnic post-stroke groups for comparison, along with the utilization of validated questionnaires to measure health-related quality of life.

Care providers' view of the barriers in providing care for adolescents with emotional and behavioral problems.

Objectives: Emotional and behavioral problems (EBP) during adolescence are a major public health issue due to its high prevalence and long-lasting consequences. The knowledge of the barriers in providing psychosocial care can be a starting point for subsequent efficiency improvement. Therefore, the aim of this study is to assess which barriers do care providers experience while providing psychosocial care for adolescents with EBP.