1 results match your criteria: "The Netherlands (I.Ho.). sebastian.grundmann@universitaets-herzzentrum.de.[Affiliation]"
MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive Neovascularization.
Circulation
May 2015
From Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Germany (F.P., X.B., S.K., I.Hi., C.S., T.H., J.S.E., M.K., M.M., C.B., S.G.); Department of Biology, Albert-Ludwigs-University, Freiburg, Germany (F.P., F.L.); Department of Hematology and Oncology, University Hospital Freiburg, Germany (R.Z., F.L.); and Experimental Cardiology Laboratory, University Medical Center Utrecht, The Netherlands (I.Ho.).
Background: Adaptive neovascularization after arterial occlusion is an important compensatory mechanism in cardiovascular disease and includes both the remodeling of pre-existing vessels to collateral arteries (arteriogenesis) and angiogenic capillary growth. We now aimed to identify regulatory microRNAs involved in the modulation of neovascularization after femoral artery occlusion in mice.
Methods And Results: Using microRNA-transcriptome analysis, we identified miR-155 as a downregulated microRNA during hindlimb ischemia.