Prediction of dementia using CT imaging in stroke (PRODUCTS).

Introduction: A better understanding of who will develop dementia can inform patient care. Although MRI offers prognostic insights, access is limited globally, whereas CT-imaging is readily available in acute stroke. We explored the prognostic utility of acute CT-imaging for predicting dementia.

Mathematical analysis of long-distance polar auxin transport data of pin mutants questions the role of PIN1 as postulated in the chemi-osmotic theory.

The plant hormone auxin (Indole-3-Acetic Acid, IAA) is a key player in nearly every aspect of plant growth and development ranging from cell division and cell elongation to embryogenesis and root formation. The IAA level in specific tissues and cells is regulated by synthesis, conjugation, degradation and transport. Especially long-range polar auxin transport (PAT) has been the subject of numerous studies.

Understanding Personalized Dynamics in Eating Disorders: A Dynamic Time Warp Analysis.

Objective: To enhance our understanding of the processes of change and the interaction of symptoms, we applied a relatively novel method known as Dynamic Time Warp to data from low-threshold internet-based interventions directed at decreasing eating disorder (ED) symptoms and increasing help-seeking.

Method: Utilizing data from the Featback study, we examined how various factors such as ED psychopathology, binge eating, vomiting, laxative use, BMI, anxiety, depression, self-efficacy, social support, well-being, and health-related quality of life interplayed over a period of 14 months among 355 individuals at six different time points. Moreover, we explored which symptoms exerted a significant temporal relationship on others (with high out-strength) and which were most affected by other symptoms (with high in-strength).

Role of Perivascular Adipose Tissue in Vein Remodeling.

Perivascular adipose tissue (PVAT) plays a crucial, yet underexplored, role in vein remodeling, which occurs after bypass surgery using a venous graft or creation of arteriovenous fistulae for hemodialysis access. PVAT exhibits significant heterogeneity in phenotype and tissue composition depending on the vascular bed, as well as its anatomic location within the vasculature. Through the excretion of adipokines, cytokines, and chemokines, PVAT can shape the vascular response to local and systemic perturbations.

Differences in Pulmonary Artery Stiffness Measured by CMR in Preterm-Born Young Adults With and Without Bronchopulmonary Dysplasia.

Background: Very preterm-born infants are at risk for developing bronchopulmonary dysplasia (BPD), a chronic lung disease. Nowadays, the majority of these infants reach adulthood. Very preterm-born young adults are at risk for developing pulmonary arterial (PA) hypertension later in life.

The impact of a virtual wound on pain sensitivity: insights into the affective dimension of pain.

Background: The perception of pain is difficult to assess due to the complex combination of various components related to nociception, experience, and cognition. There are currently no biomarkers to assess the affective component of pain in healthy volunteers. Using Virtual Reality (VR), it may be possible to assess changes in pain perception when adding an affective component to painful stimulation.

Perceived value of video games, but not hours played, predicts mental well-being in casual adult Nintendo players.

Studies on video games and well-being often rely on self-report measures or data from a single game. Here, we study how 703 casually engaged US adults' time spent playing for over 140 000 h across 150 Nintendo Switch games relates to their life satisfaction, affect, depressive symptoms and general mental well-being. We replicate previous findings that playtime over the past two weeks does not predict well-being, and extend these findings to a wider range of timescales (1 h to 1 year).

Eyebrow movements as signals of communicative problems in human face-to-face interaction.

Repair is a core building block of human communication, allowing us to address problems of understanding in conversation. Past research has uncovered the basic mechanisms by which interactants signal and solve such problems. However, the focus has been on verbal interaction, neglecting the fact that human communication is inherently multimodal.

The Controversy Surrounding the Arcade of Struthers: A Systematic Review of Literature.

The arcade of Struthers was first described by Kane et al in 1973 as a thickening of the deep investing fascia of the distal arm and superficial fibers of the medial head of the triceps muscle extending to the medial intermuscular septum. However, existence of anatomical structure remains disputed, lacking a unanimous consensus. This systematic review aims to provide an overview of all findings and conclusions on this subject.

Belonging: a meta-theme analysis of women's community-making in group antenatal and postnatal care.

Health care systems are social institutions simulating microcosms of wider societies where unequal distribution of power and resources translate into inequities in health outcomes, experiences and access to services. Growing research on participatory women's groups positively highlights the influence of group-based care on health and wellbeing for women, their infants, families and wider communities across different countries. With similarities in ethos and philosophies, group care combines relational, group-based facilitation and clinical care, uniquely offering an opportunity to examine the intersections of health and social care.

Generational differences in healthcare: the role of technology in the path forward.

Healthcare systems worldwide are under increasing pressure due to aging populations, rising prevalence of chronic diseases, and heightened patient expectations. Generational differences significantly impact perceptions of health, healthcare decision-making, use of digital technologies, and attitudes toward preventative health. This perspective article explores these differences through the lens of Generational Cohort Theory, focusing on six generations: the Silent Generation, Baby Boomers, Generation X, Millennials, Generation Z, and Generation Alpha.

Mapping curvature domains in human V4 using CBV-sensitive layer-fMRI at 3T.

Introduction: A full understanding of how we see our world remains a fundamental research question in vision neuroscience. While topographic profiling has allowed us to identify different visual areas, the exact functional characteristics and organization of areas up in the visual hierarchy (beyond V1 & V2) is still debated. It is hypothesized that visual area V4 represents a vital intermediate stage of processing spatial and curvature information preceding object recognition.

Out of Breath, out of Options: Benralizumab as a Last Hope in ICU-Treated Near-Fatal Eosinophilic Asthma: A Case Series.

Asthma exacerbations remain life-threatening events despite advancements in biologic therapies. This case series reports on four patients with near-fatal eosinophilic asthma exacerbations who had been admitted to intensive care and were treated with benralizumab as a last resort after failing maximal standard therapies. All patients exhibited marked blood or airway eosinophilia and required intensive care ventilatory support.

Implicit neural representation of multi-shell constrained spherical deconvolution for continuous modeling of diffusion MRI.

Diffusion magnetic resonance imaging (dMRI) provides insight into the micro and macro-structure of the brain. Multi-shell multi-tissue constrained spherical deconvolution (MSMT-CSD) models the underlying local fiber orientation distributions (FODs) using the dMRI signal. While generally producing high-quality FODs, MSMT-CSD is a voxel-wise method that can be impacted by noise and produce erroneous FODs.

Designing qualitative research with value in the clinical and epidemiological context: what, why and how.

Clinical and epidemiological research is indispensable for improvements in evidence-based healthcare and health outcomes, but it also leaves important gaps in our understanding of health and illness. Qualitative research has been increasingly recognized as a key to addressing some of these gaps, using both exploratory (to gain a more complete and in-depth understanding of problems) and explanatory (to explain quantitative results) approaches. By finding out 'what's going on' and bringing people's stories to light, qualitative research is widely advocated as crucial in enhancing patient-centered research and healthcare.

Perspectives on access to imaging digital health records in oncology: A mixed methods systematic review.

Background: Digital Health Records (DHR) have become essential for managing patient data, including radiology and nuclear medicine reports. The wider adoption of DHR globally presents an opportunity to improve patient engagement and empowerment through effective access and sharing of imaging investigations. This review aims to synthesize literature on views, experiences, expectations, and preferences of oncology patients and healthcare professionals (HCP) when accessing imaging via DHR.

Transcutaneous Pulsed Radiofrequency Treatment in Patients with Osteoarthritis of the Upper Extremity.

Background: Non-invasive treatment options are preferred for managing upper extremity pain due to osteoarthritis (OA). Transcutaneous pulsed radiofrequency (TcPRF) is a promising technique and appears effective in managing knee and shoulder pain.

Objectives: To investigate whether TcPRF treatment is effective in reducing pain and safe to use among patients with OA of the upper extremity.

Effects of cervical transcutaneous Vagus Nerve Stimulation (ctVNS) on military cognitive performance during sleep deprivation.

Introduction: Maintaining cognitive performance during sleep deprivation is of vital importance in many professions, especially in high-risk professions like the military. It has long been known that sleep deprivation diminishes cognitive performance. To mitigate the negative effects on cognitive performance during crucial military tasks, new interventions are necessary.

Patient experiences with and adherence to Crohn's disease exclusion diet in Dutch Crohn's disease patients: a cohort study.

Background: Dietary therapy is commonly used as a treatment for Crohn's disease (CD). High dietary adherence is associated with achieving clinical remission. Crohn's disease exclusion diet (CDED) is a relatively new therapy in the management of CD.

Prevalence of Silicone Lymphadenopathy in Women with Breast Implants: A single-center retrospective study.

Introduction: Silicone lymphadenopathy (SLA) is a known finding after breast implant surgery. The prevalence of SLA is unknown and therefore its clinical implications are unclear. To make a statement about the clinical importance of SLA, more knowledge on its prevalence is necessary.

CT- and MRI-based volumetry for Chiari-like malformation and syringomyelia in Pomeranians.

Introduction: Volumetric studies in relation to CM/SM have not been reported in Pomeranians. In this study, we aim to (1) report the intermodality agreement between CT- and MRI-based volumetric measurements of the skull and cervical spinal canal, and (2) assess for differences and associations between the volumetric measurements and CM/SM status.

Methods: Pomeranians were included that underwent CT and MRI studies during the period of February 2022-June 2024.

"From my life, she will never be gone, even though she is no longer here" - a single case interpretative phenomenological analysis on spousal loss and resilience.

Older people often face drastic life events, such as spousal loss, that profoundly affect their daily lives. Consequently, resilience-how one navigates life's changes to avoid further adverse outcomes-is increasingly relevant in ageing studies. Although understanding older adults' resilience is key to preventing adverse outcomes, the complexity of loss-related events and everyday resilience in later life is underexplored from a process-based perspective.

The prevalence of peanut-triggered food protein-induced enterocolitis syndrome in a prospective cohort of infants introducing peanut in the first year of life.

Background: Since the early introduction of peanut to prevent IgE-mediated peanut allergy, other case series have suggested an increased incidence of peanut-triggered Food Protein Induced Enterocolitis Syndrome (FPIES). Data on the prevalence of peanut-induced FPIES in prospective cohorts are lacking.

Methods: The PeanutNL cohort is a prospective cohort that included infants at risk of peanut allergy (n = 706) as well as infants with reactions to peanut at home after early introduction (n = 186).

Impact of Post Percutaneous Coronary Intervention Fractional Flow Reserve on 5-Year Clinical Outcomes (The FFR SEARCH Study).

Background: Fractional flow reserve (FFR) following percutaneous coronary intervention (PCI) can be used to evaluate procedural success and to guide stent optimization. Several studies have demonstrated that lower FFR after stent implantation is associated with increased adverse event rates up to 2 years. However, the impact of post-PCI FFR on very long-term clinical outcome remains unknown.

Opening up the black box of chaplaincy: a qualitative study into the reported workings of a narrative and interfaith spiritual care intervention in palliative care at home.

This study investigated the reported workings of a narrative and interfaith spiritual care intervention in palliative care at home called "In dialogue with your life story." It was developed to address clients' spiritual needs in the religious plural context of the Netherlands. Thus far, how the intervention impacted clients' spiritual well-being remained a black box.