Comment on van Gemert et al. Child Abuse, Misdiagnosed by an Expertise Center-Part II-Misuse of Bayes' Theorem. 2023, , 843.

Recently, part I and part II of a series of three papers were published, namely the papers by Vlaming et al [...

Integration of Stromal Cells and Hydrogel Below Epithelium Results in Optimal Barrier Properties of Small Intestine Organoid Models.

: The barrier properties of the human small intestine play a crucial role in regulating digestion, nutrient absorption and drug metabolism. Current in vitro organotypic models consist only of an epithelium, which does not take into account the possible role of stromal cells such as fibroblasts or the extracellular matrix (ECM) which could contribute to epithelial barrier properties. Therefore, the aim of this study was to determine whether these stromal cells or ECM were beneficial or detrimental to barrier function when incorporated into an organotypic human small intestine model.

The Differential Complement, Fc and Chemokine Receptor Expression of B Cells in IgG4-Related Pancreatobiliary Disease and Primary Sclerosing Cholangitis and Its Relevance for Targeting B Cell Pathways in Disease.

Immune-mediated liver and biliary conditions, such as IgG4-related pancreatobiliary disease (IgG4-PB) and a subset of primary sclerosing cholangitis (PSC- high(h)IgG4), exhibit increased IgG4 levels in the blood. The relative expression of IgG4+ and IgG1+ B cells in the blood and the expression of complement and Fc receptors on these IgG1+ and IgG4+ B cells in IgG4-PB and PSC have not been previously described. We hypothesised that the patterns of expression of these cells and their receptors would differ, are relevant to disease pathogenesis and may represent therapeutic targets.

Machine Learning for Early Detection of Cognitive Decline in Parkinson's Disease Using Multimodal Biomarker and Clinical Data.

: Parkinson's disease (PD) is the second most common neurodegenerative disease, primarily affecting the middle-aged to elderly population. Among its nonmotor symptoms, cognitive decline (CD) is a precursor to dementia and represents a critical target for early risk assessment and diagnosis. Accurate CD prediction is crucial for timely intervention and tailored management of at-risk patients.

Pharmacotherapy from Pre-COVID to Post-COVID: Longitudinal Trends and Predictive Indicators for Long COVID Symptoms.

Background/objectives: A significant number of COVID-19 cases experience persistent symptoms after the acute infection phase, a condition known as long COVID or post-acute sequelae of COVID-19. Approved prevention and treatment options for long COVID are currently lacking. Given the heterogeneous nature of long COVID, a personalized medicine approach is essential for effective disease management.

Xanthohumol: Anti-Inflammatory Effects in Mechanically Stimulated Periodontal Ligament Stem Cells.

Background/objectives: Initial sterile inflammation is an essential molecular process in the periodontium during orthodontic tooth movement. A better understanding and possible modulations of these processes are of great interest to develop individual therapies for special patient groups. The prenylated plant polyphenol xanthohumol (XN) could have modulating effects as it has shown anti-inflammatory and angiogenesis-inhibiting effects in various cell lines.

Domestic Use of E-Cargo Bikes and Other E-Micromobility: Protocol for a Multi-Centre, Mixed Methods Study.

Physical inactivity is a leading risk factor for non-communicable diseases. Climate change is now regarded as the biggest threat to global public health. Electric micromobility (e-micromobility, including e-bikes, e-cargo bikes, and e-scooters) has the potential to simultaneously increase people's overall physical activity while decreasing greenhouse gas emissions where it substitutes for motorised transport.

Malaria Prevention for Pregnant Women and Under-Five Children in 10 Sub-Saharan Africa Countries: Socioeconomic and Temporal Inequality Analysis.

Background: Malaria remains a public health challenge in low- and middle-income countries (LMICs). Despite gains from strategies like Insecticide-Treated Nets (ITNs) and Intermittent Preventive Treatment during pregnancy (IPTp), significant socioeconomic inequalities persist, particularly among pregnant women and children under five. This study analyzed temporal and socioeconomic inequalities in malaria prevention in sub-Saharan Africa (SSA).

The Intersection of Personality Dimensions with Stress Relief Strategies in Adolescence: An Experimental Study.

Stress is becoming more prevalent among adolescents and negatively impacts their health and development. It is, therefore, pivotal to increase our knowledge about potential (personalized) healthy stress relief strategies for adolescents. This study investigated individual personality differences (i.

Scoping Review of Climate Change Adaptation Interventions for Health: Implications for Policy and Practice.

Climate change is among the greatest threats to health in the 21st century, requiring the urgent scaling-up of adaptation interventions. We aim to summarise adaptation interventions that were funded by the Belmont Forum and the European Union, the largest global funders of climate change and health research. A systematic search was conducted (updated February 2023) to identify articles on adaptation interventions for health within this funding network.

An Organizational-Level Workplace Intervention to Improve Medical Doctors' Sustainable Employability: Study Protocol for a Participatory Action Research Study.

Compromised Sustainable Employability (SE) of medical doctors is a concern for the viability of healthcare and, thus, for society as a whole. This study (preregistration: ISRCTN15232070) will assess the effect of a two-year organizational-level workplace intervention using a Participatory Action Research (PAR) approach on the primary outcome SE (i.e.

Feasibility of Schema Therapy for Recurrent Depression in a Disaster Relief Worker with Prior Post-Traumatic Stress Disorder Treatment Using Prolonged Exposure Therapy.

This report presents the follow-up treatment course of a previously published case that demonstrated the effectiveness of prolonged exposure (PE) therapy for a disaster relief worker. The patient, a municipal employee in Fukushima Prefecture, developed post-traumatic stress disorder (PTSD) and mood disorders after the 2011 Great East Japan Earthquake and subsequent disasters. This follow-up focuses on the period from 2021 to early 2024, during which the patient experienced symptom recurrence after his father's death.

Health and Liver Diagnostic Markers Influencing Glycemia in Subjects with Prediabetes: Preview Study.

Introduction: Glucose homeostasis may be dependent on liver conditions and influence health-related markers and quality of life (QoL) objective measurements. This study aimed to analyze the interactions of glycemia with liver and health status in a prediabetic population.

Subjects And Methods: This study included 2220 overweight/obese prediabetics from the multinational PREVIEW project.

Surgical Outcomes in Laparoscopic Hysterectomy, Robotic-Assisted, and Laparoscopic-Assisted Vaginal Hysterectomy for Uterine and Cervical Cancers: A Systematic Review.

Background/objectives: This systematic review aimed to evaluate the outcomes of minimally invasive techniques in gynecological cancer surgery, specifically laparoscopic hysterectomies (LHs), robotic-assisted hysterectomies (RHs), and laparoscopic-assisted vaginal hysterectomies (LAVHs).

Methods: We conducted a comprehensive search of electronic databases including PubMed and MedLine from January 2010 to August 2024. The search included randomized controlled trials (RCTs) and observational studies.

The Refractive Index of Human Milk Serum: Natural Variations and Dependency on Macronutrient Concentrations.

The refractive index (RI) of human milk serum (also known as whey, milk soluble fraction or milk plasma) depends on the individual molecular species dissolved in the serum and their concentrations. Although the human milk serum RI is known to influence milk analysis methods based on light scattering, the RI dependency on human milk serum composition is currently unknown. Therefore, we systematically evaluate how the RI depends on natural variations in macronutrient concentrations in the soluble fraction.

Genetic Variations on Chromosome 6p21 Are Associated with Asthma Risk and Disease Severity: A Case-Control Study from Pakistan.

Background: Genetic factors play a role in asthma severity. However, low- and middle-income countries have minimal contribution to genomic asthma research. The current study investigates the influence of an important genetic asthma region (6p21) on severe asthma in a cohort of asthmatics in Pakistan.

Exploring Immune Cell Infiltration and Small Molecule Compounds for Ulcerative Colitis Treatment.

Background/objectives: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a relapsing nature and complex etiology. Bioinformatics analysis has been widely applied to investigate various diseases. This study aimed to identify crucial differentially expressed genes (DEGs) and explore potential therapeutic agents for UC.

Ornstein-Uhlenbeck Adaptation as a Mechanism for Learning in Brains and Machines.

Learning is a fundamental property of intelligent systems, observed across biological organisms and engineered systems. While modern intelligent systems typically rely on gradient descent for learning, the need for exact gradients and complex information flow makes its implementation in biological and neuromorphic systems challenging. This has motivated the exploration of alternative learning mechanisms that can operate locally and do not rely on exact gradients.

Computing Entropy for Long-Chain Alkanes Using Linear Regression: Application to Hydroisomerization.

Entropies for alkane isomers longer than C are computed using our recently developed linear regression model for thermochemical properties which is based on second-order group contributions. The computed entropies show excellent agreement with experimental data and data from Scott's tables which are obtained from a statistical mechanics-based correlation. Entropy production and heat input are calculated for the hydroisomerization of C isomers in various zeolites (FAU-, ITQ-29-, BEA-, MEL-, MFI-, MTW-, and MRE-types) at 500 K at chemical equilibrium.

Joint Communication and Channel Discrimination.

We consider a basic joint communication and sensing setup comprising a transmitter, a receiver and a sensor. The transmitter sends a codeword to the receiver through a discrete memoryless channel, and the receiver is interested in decoding the transmitted codeword. At the same time, the sensor picks up a noisy version of the transmitted codeword through one of two possible discrete memoryless channels.

Cascades Towards Noise-Induced Transitions on Networks Revealed Using Information Flows.

Complex networks, from neuronal assemblies to social systems, can exhibit abrupt, system-wide transitions without external forcing. These endogenously generated "noise-induced transitions" emerge from the intricate interplay between network structure and local dynamics, yet their underlying mechanisms remain elusive. Our study unveils two critical roles that nodes play in catalyzing these transitions within dynamical networks governed by the Boltzmann-Gibbs distribution.

The Quantum Memory Matrix: A Unified Framework for the Black Hole Information Paradox.

We present the Quantum Memory Matrix (QMM) hypothesis, which addresses the longstanding Black Hole Information Paradox rooted in the apparent conflict between Quantum Mechanics (QM) and General Relativity (GR). This paradox raises the question of how information is preserved during black hole formation and evaporation, given that Hawking radiation appears to result in information loss, challenging unitarity in quantum mechanics. The QMM hypothesis proposes that space-time itself acts as a dynamic quantum information reservoir, with quantum imprints encoding information about quantum states and interactions directly into the fabric of space-time at the Planck scale.

Properties of Maxentropic DNA Synthesis Codes.

Low-weight codes have been proposed for efficiently synthesizing deoxyribonucleic acid (DNA) for massive data storage, where a multiple of DNA strands are synthesized in parallel. We report on the redundancy and information rate of maxentropic low-weight codes for asymptotically large codeword length. We compare the performance of low-complexity nibble replacement (NR) codes, which are designed to minimize the synthesis time, with the performance of maxentropic low-weight codes.

Antimicrobial Usage and Antimicrobial Resistance in Commensal from Broiler Farms: A Farm-Level Analysis in West Java, Indonesia.

Antimicrobial resistance (AMR) is a global public health threat, with antimicrobial use (AMU) in livestock recognized as a significant driver. This study examines farm-level AMU and AMR as well as the relationship between AMU and AMR on broiler farms in Indonesia. Data were collected from 19 farms in West Java between 2019 and 2021 to examine AMU in depth across four to five successive production cycles.