Nutrition Users' Guides: RCTs Part 2 - structured guide for interpreting and applying study results from randomised controlled trials on therapy or prevention questions.

This article continues from a prior commentary on evaluating the risk of bias in randomised controlled trials addressing nutritional interventions. Having provided a synopsis of the risk of bias issues, we now address how to understand trial results, including the interpretation of best estimates of effect and the corresponding precision (eg, 95% CIs), as well as the applicability of the evidence to patients based on their unique circumstances (eg, patients' values and preferences when trading off potential desirable and undesirable health outcomes and indicators (eg, cholesterol), and the potential burden and cost of an intervention). Authors can express the estimates of effect for health outcomes and indicators in relative terms (relative risks, relative risk reductions, OR or HRs)-measures that are generally consistent across populations-and absolute terms (risk differences)-measures that are more intuitive to clinicians and patients.

Prevalence and predictive factors of testosterone-induced erythrocytosis: a retrospective single center study.

Aim: This study analyzes the prevalence and predictive factors of testosterone-induced erythrocytosis (TIE) in patients receiving testosterone replacement therapy (TRT).

Methods: Retrospective single-center observational study.

Results: 247 patients were included; median age was 47.

External negative pressure improves lung aeration in near-term rabbit kittens at risk of developing respiratory distress.

Introduction: As airway liquid is cleared into lung interstitial tissue after birth, the chest wall must expand to accommodate this liquid and the incoming air. We examined the effect of applying external positive and negative pressures to the chest wall on lung aeration in near-term rabbit kittens at risk of developing respiratory distress.

Methods: Rabbit kittens (30 days; term ∼31 days) were randomised into and groups.

Solar Wind Magnetosphere Ionosphere Link Explorer (SMILE): Science and Mission Overview.

The Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) was proposed to the Chinese Academy of Science (CAS) and the European Space Agency (ESA) following a joint call for science missions issued in January 2015. SMILE was proposed by a team of European and Chinese scientists, led by two mission Co-PIs, one from China and one from Europe. SMILE was selected in June 2015, and its budget adopted by the Chinese Academy of Sciences in November 2016 and the ESA Science Programme Committee in March 2019, respectively.

The progress in the field of clinical staging for mental disorders within the last decade: an updated systematic review.

Introduction: Clinical staging aims to refine psychiatric diagnosis by describing mental disorders on a continuum of disorder progression, with the pragmatic goal of improved treatment planning and outcome prediction. The first systematic review on this topic, published a decade ago, included 78 papers, and identified separate staging models for schizophrenia, unipolar depression, bipolar disorder, panic disorder, substance use disorder, anorexia, and bulimia nervosa. The current review updates this review by including new proposals for staging models and by systematically reviewing research based upon full or partial staging models since 2012.

Effects of non-pharmacological interventions on the depressive outcomes in people with mild cognitive impairment: an overview of systematic reviews.

Objective: This study aimed to summarize and assess the certainty of evidence of non-pharmacological interventions (NPIs) on the depressive outcomes in people with mild cognitive impairment (MCI) based on published systematic reviews (SRs).

Method: Databases including PubMed, EMBASE, PsycINFO, the Cochrane Database of Systematic Reviews, CNKI, CBM, Wanfang and VIP database were searched from their inception to June 6, 2023. The methodological quality of the SRs was evaluated using the AMSTAR2 tool, and the quality of evidence was assessed using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) framework.

Perspectives of People with Type 2 Diabetes Mellitus Towards a Decision Aid Assessing Preferences of Glucose-Lowering Drugs: The Dilemma of Choosing.

Background: Treatment guidelines recommend metformin as initial drug in many people with type 2 diabetes (T2D) and low risk of cardiovascular disease, with the possibility to switch to or add other drug classes. A decision aid (DA) could be useful to incorporate a patient's preferences in the decision of which drug class to choose. We developed such a DA and assessed the perspectives of people with T2D towards its comprehensibility and usability.

Adult phenotypes of genetic developmental and epileptic encephalopathies.

Developmental and epileptic encephalopathies constitute a group of severe epilepsies, with seizure onset typically occurring in infancy or childhood, and diverse clinical manifestations, including neurodevelopmental deficits and multimorbidities. Many have genetic aetiologies, identified in up to 50% of individuals. Whilst classically considered paediatric disorders, most are compatible with survival into adulthood, but their adult phenotypes remain inadequately understood.

Physical functioning before knee arthroplasty is not associated with (standardized) preoperative physiotherapy, but is tied to physical functioning 1-year post-surgery: A prospective cohort study.

Background: and purpose This study investigates whether a (regionally) standardized physiotherapy approach, employing a stepped-care model, can more effectively enhance preoperative physical function in end-stage osteoarthritis (OA) patients undergoing total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) and improve postoperative outcomes, addressing the current gap in understanding the impact of such interventions.

Methods: This mono-center observational prospective cohort study followed 216 primary UKA or TKA patients for one-year post-surgery. Preoperative physiotherapy, recorded through self-reported questionnaires, included standardization and treatment frequency details.

Explorative Study of Modulatory Effects of Notochordal Cell-Derived Extracellular Vesicles on the IL-1β-Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants.

Background: Cell-free regenerative strategies, such as notochordal cell (NC)-derived extracellular vesicles (EVs), are an attractive alternative in developing new therapies for intervertebral disc (IVD) degeneration. NC-EVs have been reported to elicit matrix anabolic effects on nucleus pulposus cells from degenerated IVDs cultured under basal conditions. However, the degenerative process is exacerbated by pro-inflammatory cytokines contributing to the vicious degenerative cycle.

Optimal Screening for Hereditary Head and Neck Paraganglioma in Asymptomatic SDHx Variant Carriers in the Netherlands.

 SDHx variant carriers have an increased risk of developing head and neck paraganglioma. The Dutch guidelines state that these patients require lifelong follow-up, but no clear recommendation is made about the frequency of screening.  To determine the annual risk of developing head and neck paraganglioma in SDHx variant carriers after a negative initial screening.

Co-creating a person-centered creative engagement intervention for Parkinson's care.

Background: Recent research in the field of "Arts and Health" has demonstrated the beneficial impact of arts-based interventions on health and well-being across diverse populations. Recognizing their potential, especially in cases where conventional healthcare cannot address the multifaceted impact of conditions such as in Parkinson's disease (PD), our study advocates for an integrative approach in medical practice and neuroscience. We recommend incorporating learning environments from the design phase through long-term care.

The effects of heritage multilingualism on foreign language learning: a comparison of children with typical language development and developmental language disorder.

Introduction: Both multilingualism and developmental language disorder (DLD) may be associated with inferior performance in the majority language, albeit for different reasons. At the same time, there is a growing body of evidence that multilingualism may have a positive effect on foreign language performance. This study tests the hypothesis that the positive effects of multilingualism on foreign language learning may be smaller in children with DLD compared to their multilingual peers with typical language development.

Relationships of sensory processing sensitivity with creativity and empathy in an adult sample.

Introduction: Sensory Processing Sensitivity (SPS) describes individual differences in sensitivity to environments, but there is little research on potential positive correlates of SPS. Hereby we investigate whether SPS and its Aesthetic Sensitivity (AES) component are associated with different facets of creativity and empathy.

Methods: Questionnaires on SPS, creativity and empathy were administered to 296 participants and data were analyzed using hierarchical multiple regression.

The role of vitamin K2 in cognitive impairment: linking vascular health to brain health.

Cognitive impairment, marked by a decline in essential mental aspects such as attention, memory, and problem-solving, is significantly correlated with advancing age. This condition presents a major challenge for the elderly, adversely affecting quality of life, diminishing independence, and imposing substantial burdens on healthcare systems. Recent research indicates that vitamin K2 may be vital for preserving brain health and cognitive function.

Clinical utility of myocardial work assessment in arterial hypertension and cardiovascular diseases.

In clinical practice, ventricular ejection fraction (EF) and global longitudinal strain (GLS) are the most often used parameters for evaluating left ventricular systolic function, despite the impact that variable loading conditions have. Alternatively, the myocardial efficiency (ME) of the heart, encompassing cardiac energy formation and dissipation, along with myocardial oxygen consumption (MVO2), is a useful surrogate for assessing myocardial work (MW), a parameter correlated with the pressure-strain loop (PSL), arterial pressure, and cardiac output (CO). This refinement proves especially practical in defining cardiac work across various clinical contexts, including arterial hypertension and heart failure (HF), the primary conditions associated with cardiovascular mortality.

Arthroplasty registries at a glance: an initiative of the International Society of Arthroplasty Registries (ISAR) to facilitate access, understanding, and reporting of registry data from an international perspective.

Background And Purpose:  The amount of information publicly available from arthroplasty registries is large but could be used more effectively. This project aims to improve the knowledge concerning existing registries to facilitate access, transparency, harmonization, and reporting.

Methods: Within the International Society of Arthroplasty Registries (ISAR) we aimed at developing, testing, adopting, and making publicly available a short, standardized registry description with items considered relevant for stakeholders using a cross-sectional study survey.

The implementation of intrathecal morphine for caesarean delivery into clinical practice, and assessment of its impact on patient-reported quality of recovery using the ObsQoR-10-Dutch scale.

Background: Optimising a mother's quality of recovery following caesarean delivery is of paramount importance as it facilitates maternal care of the newborn and affects physical, psychological and emotional well being. Intrathecal morphine (ITM) reduces postoperative pain and may improve quality of recovery: however its widespread use is limited.

Objective: To assess the effects of implementing ITM for caesarean delivery on postoperative quality of recovery.

upregulates the immune inhibitory receptor in colorectal cancer cells via the activation of ALPK1.

is a Gram-negative oncobacterium that is associated with colorectal cancer. The molecular mechanisms utilized by to promote colorectal tumor development have largely focused on adhesin-mediated binding to the tumor tissue and on the pro-inflammatory capacity of . However, the exact manner in which promotes inflammation in the tumor microenvironment and subsequent tumor promotion remains underexplored.

Unveiling New Reactivities in Complex Mixtures: Synthesis of Tricyclic Pyridinium Derivatives.

The discovery of new transformations drives the development of synthetic organic chemistry. While the main goal of synthetic chemists is to obtain the maximum yield of a desired product with minimal side product formation, meticulous characterization of the latter offers an opportunity for discovering new reaction pathways, alternative mechanisms, and new products. Herein, we present a case study on the discovery and development of a new chemical transformation using online mass spectrometry.

COVID-19, Autism, and Isolation: Good Practices for Continuity of Care During the Pandemic.

The COVID-19 pandemic, and particularly the associated conditions of isolation, has detrimental effects on the mental health of the population that are not yet fully understood. Variables such as individual stress, anxiety, and tolerance to uncertainty may play a role in the ability of individuals to adapt to the isolation situation. In this context, it is necessary to pay attention to population groups that present difficulties in adapting to this situation of uncertainty, such as people with autism.

Leading value-based health care: The role of leadership in integrated practice units.

Background: An important aspect of value-based health care is providing care in an integrated practice unit (IPU). In an IPU, the full cycle of care for a specific medical condition is delivered through collaboration among professionals with diverse functional backgrounds. Although the proposed functioning of an IPU in the literature on value-based health care is based on assumptions about leadership, the role of leadership in the context of IPUs is overlooked in empirical studies.

The Effects of Self-Monitoring Using a Smartwatch and Smartphone App on Stress Awareness, Self-Efficacy, and Well-Being-Related Outcomes in Police Officers: Longitudinal Mixed Design Study.

Background: Wearable sensor technologies, often referred to as "wearables," have seen a rapid rise in consumer interest in recent years. Initially often seen as "activity trackers," wearables have gradually expanded to also estimate sleep, stress, and physiological recovery. In occupational settings, there is a growing interest in applying this technology to promote health and well-being, especially in professions with highly demanding working conditions such as first responders.