4 results match your criteria: "The National Institutes of Biomedical Innovation[Affiliation]"
"Chance and Necessity" on the Molecular Evolution of REV3 (a Catalytic Subunit of DNA Polymerase ζ)-The Dual Roles of Translesion and Neuronal Extension.
Genes Cells
January 2025
Department of Genetic Biochemistry, The National Institutes of Biomedical Innovation, Health and Nutrition, Shinjuku-ku, Tokyo, Japan.
Catalytic subunit of DNA polymerase ζ (REV3), involved in translesion-replication is evolutionarily conserved from yeast and plants to higher eukaryotes. However, a large intermediate domain is inserted in REV3 of humans and mice. The domain has "DUF4683" region, which is significantly similar to human neurite extension and migration factor (NEXMIF).
View Article and Find Full Text PDFAdherence to the Japanese Food Guide: The Association between Three Scoring Systems and Cardiometabolic Risks in Japanese Adolescents.
Nutrients
December 2021
Department of Social and Preventive Epidemiology, Graduate School of Medicine and School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
The Japanese Food Guide Spinning Top (JFGST) indicates optimal intake of five food groups (grain, fish and meat, vegetables, milk, and fruits) and sugar and confectionaries. We aimed to investigate whether adherence to the JFGST in 8th grade junior high school students ( = 3162) was associated with cardiometabolic risks and how different scorings of the JFGST influenced the associations. Metabolic risks were assessed from anthropometrics, blood pressure measurements, and blood glucose and lipid profile measurements.
View Article and Find Full Text PDFA large intermediate domain of vertebrate REV3 protein is dispensable for ultraviolet-induced translesion replication.
DNA Repair (Amst)
February 2021
Department of Genetic Biochemistry, The National Institutes of Biomedical Innovation, Health and Nutrition, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162-8636, Japan. Electronic address:
DNA polymerase ζ (pol ζ) is involved in translesion replication (translesion synthesis, TLS) and plays an essential role in embryogenesis. In adults, pol ζ triggers mutation as a result of error-prone TLS and causes carcinogenesis. The catalytic subunit of pol ζ, REV3, is evolutionarily conserved from yeast and plants to higher eukaryotes.
View Article and Find Full Text PDFVasculitis and crescentic glomerulonephritis in a newly established congenic mouse strain derived from ANCA-associated vasculitis-prone SCG/Kj mice.
Autoimmunity
July 2020
Asia International Institute of Infectious Disease Control, Teikyo University, Tokyo, Japan.
Article Synopsis
- - Lupus nephritis (LN) is a type of kidney inflammation linked to systemic lupus erythematosus (SLE) and is associated with immune complex issues, while antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) leads to serious conditions like lung hemorrhage and kidney failure.
- - Research has identified specific genetic factors related to AAV using a mouse model (SCG/Kj) that mimics human AAV, by creating congenic mice to study the roles of these genetic traits.
- - The study found that B6/lpr mice, a kind of congenic model, displayed symptoms of glomerulonephritis and vasculitis