77 results match your criteria: "The National Institute on Aging[Affiliation]"
Does When You Die Depend on Where You Live? Evidence from Hurricane Katrina.
Am Econ Rev
November 2020
Deryugina: University of Illinois at Urbana-Champaign, and NBER; Molitor: University of Illinois at Urbana-Champaign, and NBER. Thomas Lemieux was the coeditor for this article. We thank Amy Finkelstein, Don Fullerton, Matthew Gentzkow, Osea Giuntella, Nathaniel Hendren, Robert Kaestner, Jonathan Ketcham, Matthew Notowidigdo, Julian Reif, Nicholas Sanders, David Slusky, and seminar participants at the ASSA Annual Meeting, the AERE Summer Conference, the Annual Health Econometrics Workshop, Arizona State University, the BFI Health Economics Initiative Annual Conference, Cornell University, East Carolina University, Georgia State University, the Heartland Environmental and Resource Economics Workshop, the Illinois pERE seminar, Indiana University, the Junior Health Economics Summit, the London School of Economics, MHEC-X, the National University of Singapore, the CEPRA/NBER Workshop on Ageing and Health, the NBER EEE Spring Meeting, the NBER Summer Institute, SIEPR, the Symposium on Natural Resource Governance for Young Scholars, the University of British Columbia, the University of California at Santa Barbara, the University of Massachusetts at Amherst, the University of South Carolina, and the University of Virginia for helpful comments. Isabel Musse, Prakrati Thakur, Fan Wu, and Zhu Yang provided excellent research assistance. Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under award numbers R21AG050795, P01AG005842, and R01AG053350. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
We follow Medicare cohorts to estimate Hurricane Katrina's long-run mortality effects on victims initially living in New Orleans. Including the initial shock, the hurricane improved eight-year survival by 2.07 percentage points.
View Article and Find Full Text PDFWhat Cut-Point in Gait Speed Best Discriminates Community-Dwelling Older Adults With Mobility Complaints From Those Without? A Pooled Analysis From the Sarcopenia Definitions and Outcomes Consortium.
J Gerontol A Biol Sci Med Sci
September 2021
University of Florida, Gainesville, USA.
Article Synopsis
- The study analyzed walking speeds of 18,632 participants aged 65 and older to define cut-points for classifying walking speed as fast, intermediate, or slow based on mobility limitations.
- Using classification and regression tree (CART) models, the analysis identified specific speed cut-points: for women, ≥0.75 m/s, ≥0.62 m/s, and <0.62 m/s; for men, ≥1.00 m/s, ≥0.74 m/s, ≥0.57 m/s, and <0.57 m/s.
- The results showed that lower walking speeds were associated with higher prevalence of self-reported mobility limitations, indicating that cut-points around 0.60 m/s
Corrigendum: Vitamin D, Folate, and Cobalamin Serum Concentrations Are Related to Brain Volume and White Matter Integrity in Urban Adults.
Front Aging Neurosci
April 2021
Department of Psychology, University of Maryland, Baltimore County, MD, United States.
[This corrects the article DOI: 10.3389/fnagi.2020.
View Article and Find Full Text PDFFrailty, With or Without Cognitive Impairment, Is a Strong Predictor of Recurrent Falls in a US Population-Representative Sample of Older Adults.
J Gerontol A Biol Sci Med Sci
October 2021
Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Background: Physical frailty and cognitive impairment have been separately associated with falls. The purpose of the study is to examine the associations of physical frailty and cognitive impairment separately and jointly with incident recurrent falls among older adults.
Methods: The analysis included 6000 older adults in community or non-nursing home residential care settings who were at least 65 years old and participated in the National Health and Aging Trends Study.
Health Equity - Are We Finally on the Edge of a New Frontier?
N Engl J Med
September 2020
From the National Institute on Aging, Baltimore.
Rapid Scaling Up of Covid-19 Diagnostic Testing in the United States - The NIH RADx Initiative.
N Engl J Med
September 2020
From the National Institute of Biomedical Imaging and Bioengineering (B.J.T.), the National Institute of Nursing Research (T.A.S.), the Office of the Director (T.A.S., R.A.B., R.L.F., F.S.C.), the National Institute on Minority Health and Health Disparities (E.J.P.-S.), the National Institute on Aging (R.J.H.), and the National Institute of Environmental Health Sciences, National Toxicology Program (R.P.W.), National Institutes of Health, Bethesda, MD.
Original Research: Understanding Nursing Home Staff Attitudes Toward Death and Dying: A Survey.
Am J Nurs
August 2020
Nhat Bui is an adult gerontology NP at the Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco (UCSF). Elizabeth Halifax is an assistant clinical professor in the UCSF School of Nursing. Daniel David is an assistant professor at the New York University Rory Meyers College of Nursing in New York City. Lauren Hunt is an assistant professor in the UCSF School of Nursing and at San Francisco Veterans Affairs Medical Center. Edyssa Uy is an NP at the City of Hope Comprehensive Cancer Center in Duarte, CA. Christine Ritchie is the Kenneth L. Minaker Chair in Geriatrics and director of research for the Division of Palliative Care and Geriatric Medicine at Massachusetts General Hospital in Boston. Caroline Stephens is an associate professor and the Helen Lowe Bamberger Colby Presidential Endowed Chair in Gerontological Nursing at the University of Utah College of Nursing in Salt Lake City. Support for this study included grants from the National Institute on Aging Paul B. Beeson Emerging Leaders Career Development Award (K76AG054862), the UCSF Pepper Center, and the National Institutes of Health (8 KL2 TR000143-08). Contact author: Nhat Bui, The authors have disclosed no potential conflicts of interest, financial or otherwise.
Background: Nearly 70% of nursing home residents are eligible for palliative care, yet few receive formal palliative care outside of hospice. Little is known about nursing home staff attitudes, knowledge, skills, and behaviors related to palliative care.
Methods: We administered a modified survey measuring attitudes toward death to 146 nursing home staff members, including both clinical and nonclinical staff, from 14 nursing homes.
A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.
N Engl J Med
July 2020
From the Boston Claude D. Pepper Older Americans Independence Center, Research Program in Men's Health: Aging and Metabolism (S. Bhasin, N.K.L., S. Basaria, T.W.S., T.G.T., L.G., B.F.B., R.E.), Brigham and Women's Hospital (S. Bhasin, N.K.L., S. Basaria, P.C.D., T.W.S., T.G.T., P.G., M.B.C., L.G., B.F.B., R.E.), Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School (T.G.T.), and the University of Massachusetts Boston (P.G.), Boston, and Meyers Primary Care Institute (joint endeavor of Reliant Medical Group, Fallon Health, and University of Massachusetts Medical School), Worcester (J.H.G.); the Yale Claude D. Pepper Older Americans Independence Center (T.M.G., P.C., K.A., J.M.M., E.A.S., D.B.), the Yale Center for Analytical Sciences (E.J.G., J.D., D.E., C.L., H.R., C.M., H.A., P.P.), and the Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine (T.M.G., H.A.), Yale University, New Haven, CT; the Multicampus Program in Geriatric Medicine and Gerontology, David Geffen School of Medicine at UCLA (D.B.R., D.A.G.), the Geriatric Research, Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System (D.A.G.), and the UCLA Claude D. Pepper Older Americans Independence Center (D.B.R, D.A.G.), Los Angeles, and HealthCare Partners, El Segundo (J.R.) - all in California; the School of Nursing, University of Minnesota, Minneapolis (S.M.M.), and Essentia Health, Duluth (S.C.W.) - both in Minnesota; Wake Forest University, School of Medicine, Winston-Salem, NC (M.E.M., P.W.D.); the University of Miami Health System, Miami (M.F.); the Pittsburgh Claude D. Pepper Older Americans Independence Center, Division of Geriatrics and Gerontology, University of Pittsburgh, Pittsburgh (S.L.G., N.M.R.); the University of Michigan, Ann Arbor (N.A., J.W.); Icahn School of Medicine at Mount Sinai, New York (F.K., A.L.S.); the UTMB Claude D. Pepper Older Americans Independence Center, Sealy Center on Aging, University of Texas Medical Branch, Galveston (E.V.); Johns Hopkins University (A.W.W., C.B.) and the University of Maryland School of Medicine (J.M.), Baltimore, and the National Institute on Aging, Bethesda (R.C.-A.) - all in Maryland; and the University of Iowa, Iowa City (R.B.W., C.C.).
Background: Injuries from falls are major contributors to complications and death in older adults. Despite evidence from efficacy trials that many falls can be prevented, rates of falls resulting in injury have not declined.
Methods: We conducted a pragmatic, cluster-randomized trial to evaluate the effectiveness of a multifactorial intervention that included risk assessment and individualized plans, administered by specially trained nurses, to prevent fall injuries.
Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross-Sectional, Population-Based Cohorts.
J Am Geriatr Soc
July 2020
California Pacific Medical Center, Research Institute, San Francisco, California.
Background/objectives: The extent to which the prevalence of muscle weakness in the US population varies by different putative grip strength constructs developed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) has not been described.
Design: Cross-sectional analysis.
Setting: Two nationally representative cohorts-2010 and 2012 waves of the Health and Retirement Survey and round 1 (2011) of the National Health and Aging Trends Survey.
Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.
J Am Geriatr Soc
July 2020
Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Objectives: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]/ht ); and slowness (walking speed <.8 m/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality).
View Article and Find Full Text PDFVitamin D, Folate, and Cobalamin Serum Concentrations Are Related to Brain Volume and White Matter Integrity in Urban Adults.
Front Aging Neurosci
May 2020
Department of Psychology, University of Maryland, Baltimore County, MD, United States.
Lower vitamin status has been linked to cognitive deficits, pending mechanistic elucidation. Serum 25-hydroxyvitamin D [25(OH)D], folate and cobalamin were explored against brain volumes and white matter integrity (WMI). Three prospective waves from Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study were used [Baltimore, City, MD, 2004-2015, = 183-240 urban adults (Age: 30-64 years)].
View Article and Find Full Text PDFDiagnosing and Treating Systemic Racism.
N Engl J Med
July 2020
From the National Institute on Aging, Baltimore (M.K.E.); and Brigham and Women's Hospital, Boston (L.R.).
A proteomic atlas of senescence-associated secretomes for aging biomarker development.
PLoS Biol
January 2020
The Buck Institute for Research on Aging, Novato, California, United States of America.
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few dozen secreted proteins, has been greatly underestimated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present the "SASP Atlas," a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors originating from multiple senescence inducers and cell types.
View Article and Find Full Text PDFThe expectation breakers.
Neurobiol Aging
November 2019
Division of Behavioral and Social Research, The National Institute on Aging, Bethesda, MD, USA.
Excessive daytime sleepiness and topographic expansion of Lewy pathology.
Neurology
October 2019
From the Institute of Human Genomic Study (R.D.A., C.S.), Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea; the Pacific Health Research and Education Institute (R.D.A., G.W.R., L.R.W., H.P.), Honolulu, HI; the Departments of Medicine (G.W.R.) and Pathology (J.H.U.-L.) and the John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine (G.W.R., K.H.M., H.P.), John A. Burns School of Medicine, University of Hawaii, Honolulu; the Veterans Affairs Pacific Islands Health Care System (G.W.R., L.R.W., H.P.), Honolulu, HI; the Michael J. Crescenz Veterans Affairs Medical Center and the University of Pennsylvania Perelman School of Medicine (J.E.D.), Philadelphia; Kuakini Medical Center (K.H.M.), Honolulu, HI; the National Institute on Aging (L.J.L.), Bethesda, MD; and the San Francisco Veterans Affairs Medical Center and the Department of Neurology (C.M.T.), University of California-San Francisco.
Objective: While excessive daytime sleepiness (EDS) can predate the clinical diagnosis of Parkinson disease (PD), associations with underlying PD pathogenesis are unknown. Our objective is to determine if EDS is related to brain Lewy pathology (LP), a marker of PD pathogenesis, using clinical assessments of EDS with postmortem follow-up.
Methods: Identification of LP was based on staining for α-synuclein in multiple brain regions in a sample of 211 men.
Establishing the Link Between Lean Mass and Grip Strength Cut Points With Mobility Disability and Other Health Outcomes: Proceedings of the Sarcopenia Definition and Outcomes Consortium Conference.
J Gerontol A Biol Sci Med Sci
June 2020
Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Background: Lack of consensus on how to diagnose sarcopenia has limited the ability to diagnose this condition and hindered drug development. The Sarcopenia Definitions and Outcomes Consortium (SDOC) was formed to develop evidence-based diagnostic cut points for lean mass and/or muscle strength that identify people at increased risk of mobility disability. We describe here the proceedings of a meeting of SDOC and other experts to discuss strategic considerations in the development of evidence-based sarcopenia definition.
View Article and Find Full Text PDFOxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice.
J Lipid Res
September 2018
Department of Pediatrics, University of California San Diego, La Jolla, CA. Electronic address:
Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with disease severity. However, the mechanisms by which OXLAMs contribute to NASH development are incompletely understood. We tested the hypothesis that LA or OXLAMs provided directly through the diet are involved in the development of hepatic injury.
View Article and Find Full Text PDFTracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data.
J Gerontol A Biol Sci Med Sci
January 2019
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Background: Epigenetic clocks based on DNA methylation yield high correlations with chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not known how Δage (epigenetic age - chronological age) changes over time or if it remains constant from childhood to old age. Here, we investigate this using longitudinal DNA methylation data from five datasets, covering most of the human life course.
View Article and Find Full Text PDFd-Serine is a potential biomarker for clinical response in treatment of post-traumatic stress disorder using (R,S)-ketamine infusion and TIMBER psychotherapy: A pilot study.
Biochim Biophys Acta Proteins Proteom
July 2018
Department of Anesthesiology, Cooper University Hospital and Cooper Medical School of Rowan University, Camden, NJ, USA. Electronic address:
Post-traumatic stress disorder (PTSD) is a chronic and debilitating condition that is often refractory to standard frontline antidepressant therapy. A promising new approach to PTSD therapy is administration of a single sub-anesthetic dose of (R,S)-ketamine (Ket). The treatment produces rapid and significant therapeutic response, which lasts for only 4-7 days.
View Article and Find Full Text PDFGenome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Nat Commun
January 2018
Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent).
View Article and Find Full Text PDFVersion 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS).
Alzheimer Dis Assoc Disord
September 2019
Department of Neurology, Washington University School of Medicine, St. Louis, MO.
Introduction: The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by the National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance in dementia and mild cognitive impairment due to Alzheimer Disease. This paper describes a revision, the UDSNB 3.0.
View Article and Find Full Text PDFPrognostic Utility of Morning Blood Pressure Surge for 20-Year All-Cause and Cardiovascular Mortalities: Results of a Community-Based Study.
J Am Heart Assoc
December 2017
Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Background: Morning blood pressure (BP) surge (MS), defined by the MS amplitude, is an independent prognostic factor of cardiovascular outcomes in some, but not all, populations.
Method And Results: We enrolled 2020 participants (1029 men; aged 30-79 years) with 24-hour ambulatory BP data. During a median 19.
GPR55 receptor antagonist decreases glycolytic activity in PANC-1 pancreatic cancer cell line and tumor xenografts.
Int J Cancer
November 2017
Laboratory of Clinical Investigation, Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224.
The Warburg effect is a predominant metabolic pathway in cancer cells characterized by enhanced glucose uptake and its conversion to l-lactate and is associated with upregulated expression of HIF-1α and activation of the EGFR-MEK-ERK, Wnt-β-catenin, and PI3K-AKT signaling pathways. (R,R')-4'-methoxy-1-naphthylfenoterol ((R,R')-MNF) significantly reduces proliferation, survival, and motility of PANC-1 pancreatic cancer cells through inhibition of the GPR55 receptor. We examined (R,R')-MNF's effect on glycolysis in PANC-1 cells and tumors.
View Article and Find Full Text PDFNovel genetic loci associated with hippocampal volume.
Nat Commun
January 2017
Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
Article Synopsis
- - The hippocampal formation is crucial for memory, navigation, and stress response, and its structural abnormalities are linked to various neuropsychiatric disorders.
- - A genome-wide association study involving over 33,000 individuals identified six genetic loci related to hippocampal volume, including four that are new discoveries associated with specific genes.
- - The study also reveals that genetic variants that result in smaller hippocampal volumes correlate with a higher risk of developing Alzheimer's disease, highlighting potential biological pathways related to mental health.